Transcription profiling of mouse Pax6 heterozygous and wildtype newborn mouse lenses

This is an integrative genome-wide approach to identify downstream networks controlled by Pax6 during mouse lens and forebrain development. Differential gene expression was analyzed in Pax6 mouse heterozygous and wildtype newborn mouse lenses, with subsequent comparison of this data with Pax6 forebrain expression data (Holm et al., 2007). Experiment Overall Design: Three biological replicate experiments were performed from wildtype and heterozygote mice.