Exon array analysis of the response to bevacizumab/erlotinib in advanced non-small cell lung cancer

·发布 2013年7月30日 ·更新 2013年8月5日

117

样本数

117

实验数

芯片平台

实验描述

In the current study, we used exon arrays and clinical samples from a previous trial (SAKK 19/05) to investigate the expression variations at the exon-level of 3 genes potentially playing a key role in modulating treatment response (EGFR, KRAS, VEGFA). Exon-level biomarkers for the response to targeted therapy bevacizumab/erlotinib were identified in patients with metastatic non-small cell lung cancer Multicenter, prospective, open-label, single-arm, phase II trial.

芯片平台

A-AFFY-143

Affymetrix GeneChip Human Exon 1.0 ST Array version 1, [HuEx-1_0-st-v1]（117 例）

样本属性

age y

32, 35, 44, 46, 47, 48, 49, 50, 51, 53, 54, 55, 56, 57, 58, 59, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 72, 74, 75, 77, 78

disease state

advanced non-small cell lung cancer

101, 102, 103, 14, 15, 16, 18, 19, 2, 20, 21, 23, 25, 26, 27, 28, 29, 3, 30, 37b, 38, 39, 40, 42, 44b, 47b, 49, 50, 51, 53, 54b, 55, 56, 57, 58, 59, 60, 61, 63, 64, 65, 66, 67, 68, 69, 7, 70, 72, 73, 74, 75, 76, 77, 78, 79, 8, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 9, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99

organism

Homo sapiens

organism part

blood, lung biopsy

sex

female, male

实验信息

登记号

E-GEOD-37138

GEO 编号

GSE37138

实验类型

transcription profiling by array

物种

Homo sapiens

发布日期

2013年7月30日

更新日期

2013年8月5日

提交者

Richard Cathomas、 Martin Brutsche、 Francesco Zappa、 Sacha Rothschild、 Miklos Pless、 Daniel Rauch、 Daniel C Betticher、 Cornelia Dröge、 Florent Baty、 Martin Früh、 Lukas Bubendorf、 Florent Baty、 Susanne Crowe、 Oliver Gautschi

外部链接

ArrayExpress 原始页 NCBI GEO：GSE37138

分析服务

Exon array analysis of the response to bevacizumab/erlotinib in advanced non-small cell lung cancer

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