micro RNA-379 couples glucocorticoid hormones to metabolic dysfunction in diabesity

·发布 2014年10月15日 ·更新 2014年10月19日

样本数

实验数

芯片平台

实验描述

In metabolic control, GC signaling acts as a major counter-regulatory system against insulin action, and aberrantly elevated GC activity is tightly linked to major components of the so-called Metabolic Syndrome, including obesity, insulin resistance, hyperglycemia, and systemic dyslipidemia. Here we identify the hepatic induction of the conserved microRNA (miR)-379/410 genomic cluster as a key component of GC/GR-driven metabolic dysfunction in “diabesity” Microarray data were utilized to screened for differentially regulated miRNAs between wt and db/db and between wt and GR Knockdown mice For wt vs. db/db: mice were fasted for 24 hours and refed for 6 hours; For GR-dependent miRNAs: mice were treated with rAAV delivering either control or GR-directed miRNA for the knockdown of the GR specifically in the liver.

芯片平台

A-GEOD-14613

[miRNA-2_0] Affymetrix Multispecies miRNA-2_0 Array（16 例）

样本属性

genotype

db/db, wildtype

organism

Mus musculus

organism part

liver

shRNA

None, GR-KD shRNA, Negative control shRNA

strain

C57BL/6J

实验信息

登记号

E-GEOD-55245

GEO 编号

GSE55245

实验类型

transcription profiling by array

物种

Mus musculus

发布日期

2014年10月15日

更新日期

2014年10月19日

提交者

Daniela Strzoda、 Roldan M de Guia、 Oksana Seibert、 Mauricio B Diaz、 Carsten Sticht、 Annika Zota、 Carsten Sticht、 Geesje Dallinga-Thie、 Sven Diederichs、 Norbert Gretz、 Stephan Herzig、 Matthias Blüher、 Anke Sommerfeld、 Adam J Rose、 Yvonne Feuchter、 Anja Krones-Herzig、 Nora Klöting

外部链接

ArrayExpress 原始页 NCBI GEO：GSE55245

分析服务

micro RNA-379 couples glucocorticoid hormones to metabolic dysfunction in diabesity

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