实验描述
We examined the role of TREM2 on microglia responses to amyloid-beta deposition in a mouse model of Alzheimer's disease Microglia were FACS-purified from 8.5 month old WT, Trem2-/-, 5XFAD, and Trem2-/- 5XFAD mice
参考文献
TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model.
Wang Y, Cella M, Mallinson K, Ulrich JD, Young KL, Robinette ML, Gilfillan S, Krishnan GM, Sudhakar S, Zinselmeyer BH, Holtzman DM, Cirrito JR, Colonna M
PMID: 25728668
芯片平台
A-AFFY-130
Affymetrix GeneChip Mouse Gene 1.0 ST Array [MoGene-1_0-st-v1](20 例)
样本属性
genotype
5XFAD transgenic, Trem2 knockout, Trem2 knockout, 5XFAD transgenic, wild type