In vivo oncogenomics screen identifies novel ependymoma oncogenes and tumor suppressor genes within large chromosomal alterations

·发布 2015年4月28日 ·更新 2015年5月2日

样本数

实验数

芯片平台

实验描述

Cancers are characterized by non-random, chromosome copy number variations that presumably contain oncogenes and tumor suppressor genes (TSGs). The affected loci are often large, making it difficult to pinpoint which genes are driving the cancer. Here, we report a cross-species, in vivo screen of 84 candidate oncogenes and 39 candidate TSGs, located within 28 recurrent chromosomal alterations in ependymoma. Through a series of mouse models we validate eight new ependymoma oncogenes and 11 TSGs that dysregulate a small number of cell functions including vesicle trafficking and cholesterol biosynthesis; pinpointing these as potential points for therapeutic intervention. Mouse cortical tumors were excised. These tumors derived from cells expressing one of 3 genes: RAB3A, BC74C, or ZNF668

芯片平台

A-GEOD-11180

[HT_MG-430_PM] Affymetrix HT MG-430 PM Array Plate（24 例）

样本属性

brain region

cortex

class gene

BC74C, RAB3A, ZNF668

organism

Mus musculus

organism part

brain

实验信息

登记号

E-GEOD-67497

GEO 编号

GSE67497

实验类型

transcription profiling by array

物种

Mus musculus

发布日期

2015年4月28日

更新日期

2015年5月2日

提交者

David Finkelstein、 Kirti Gupta、 Jason Dapper、 Christopher Eden、 Arzu O Thomas、 Geoffrey Neale、 Richard J Gilbertson、 Karen Wright、 Michele Connelly、 David W Ellison、 Nidal Boulos、 Yong-Dong Wang、 Scott Olsen、 Kumarasamypet M Mhankumar、 Elsie White、 Radhika Thiruvenkatam、 Birgit Nimmervoll、 Tanya A Kranenburg、 David S Currle

外部链接

ArrayExpress 原始页 NCBI GEO：GSE67497

分析服务

In vivo oncogenomics screen identifies novel ependymoma oncogenes and tumor suppressor genes within large chromosomal alterations

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