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E-GEOD-68720 GSE68720 transcription profiling by array Homo sapiens

caArray_EXP-520: Gene Expression Profiles Predictive of Outcome and Age in Infant Acute Lymphoblastic Leukemia: a Children's Oncology Group Study

·发布 2015年5月12日 ·更新 2015年5月22日

样本数

实验数

芯片平台

相关文献

实验描述

Gene expression profiling was performed on 97 cases of infant ALL from Children's Oncology Group Trial P9407. Statistical modeling of an outcome predictor revealed 3 genes highly predictive of event-free survival (EFS), beyond age and MLL status: FLT3, IRX2, and TACC2. Low FLT3 expression was found in a group of infants with excellent outcome (n = 11; 5-year EFS of 100%), whereas differential expression of IRX2 and TACC2 partitioned the remaining infants into 2 groups with significantly different survivals (5-year EFS of 16% vs 64%; P < .001). When infants with MLL-AFF1 were analyzed separately, a 7-gene classifier was developed that split them into 2 distinct groups with significantly different outcomes (5-year EFS of 20% vs 65%; P < .001). In this classifier, elevated expression of NEGR1 was associated with better EFS, whereas IRX2, EPS8, and TPD52 expression were correlated with worse outcome. This classifier also predicted EFS in an independent infant ALL cohort from the Interfant-99 trial. When evaluating expression profiles as a continuous variable relative to patient age, we further identified striking differences in profiles in infants less than or equal to 90 days of age and those more than 90 days of age. These age-related patterns suggest different mechanisms of leukemogenesis and may underlie the differential outcomes historically seen in these age groups. EXP-520 Assay Type: Gene Expression Provider: Affymetrix Array Designs: HG-U133_Plus_2 Organism: Homo sapiens (ncbitax)

参考文献

Gene expression profiles predictive of outcome and age in infant acute lymphoblastic leukemia: a Children's Oncology Group study.

Kang H, Wilson CS, Harvey RC, Chen IM, Murphy MH, Atlas SR, Bedrick EJ, Devidas M, Carroll AJ, Robinson BW, Stam RW, Valsecchi MG, Pieters R, Heerema NA, Hilden JM, Felix CA, Reaman GH, Camitta B, Winick N, Carroll WL, Dreyer ZE, Hunger SP, Willman CL

PMID: 22210879

芯片平台

A-AFFY-44

Affymetrix GeneChip Human Genome U133 Plus 2.0 [HG-U133_Plus_2]（97 例）

样本属性

age

1, 100, 105, 106, 116, 117, 119, 122, 124, 126, 135, 141, 150, 151, 152, 154, 157, 160, 166, 168, 169, 17, 179, 182, 183, 186, 198, 2, 200, 208, 209, 21, 211, 212, 215, 220, 222, 230, 234, 239, 242, 245, 248, 256, 260, 261, 264, 265, 267, 273, 285, 287, 29, 291, 296, 306, 315, 327, 331, 336, 339, 34, 349, 354, 356, 36, 363, 364, 365, 41, 45, 54, 55, 56, 57, 60, 62, 63, 64, 67, 70, 80, 87, 90, 92, 94, 99

blast_count

-1, 70, 75, 80, 85, 90, 95

cohort

COHORT 1, COHORT 2, COHORT 3

ethnicity

Hispanic or Latino, Not Hispanic or Latino, Unknown(Individuals not reporting ethnicity)

gene

--, AF4, AF9, ENL, MLL_G, OTHER MLL

karyotype

--, 45,XX,DEL(6)(Q15Q23),DIC(7;9)(P11.2;P11),-13,DEL(20)(Q11.2Q13.1),+MAR[15]/46,XX[8], 45,XY,DIC(7;9)(Q11.1;P21)[9]/46,XY[11], 46,XX,DER(4)T(4;13)(Q21;Q14),DER(11)INS(11;4)(Q23;Q21Q31.1),DER(13)T(4;13)(Q21;Q14)[17], 46,XX,DER(4)T(4;6)(Q13.3;Q21),DER(6)T(4;6)(Q13.3;Q21)INS(4;11)(Q21;Q23Q23),DEL(11)(Q23Q23)[8]/46,IDEM,DEL(5)(Q33)[8]/46,IDEM,ADD(2)(Q37)[2]/46,XX[2], 46,XX,DER(5)INV(5)(P15.1Q13)T(5;19;15)(Q13;Q13.3;Q11.2),DER(15)T(5;19;15)(Q13;Q13.3;Q11.2),DER(19)T(5;19;15)(Q13.Q13.3;Q11.2)[7]/46,XX[13], 46,XX,INS(4;11)(Q21;Q21Q23),DEL(18)(Q21)[5]/46,XX[15], 46,XX,T(11;19)(Q23;P13.3)[14]/46,XX[2], 46,XX,T(11;19)(Q23;P13.3)[18], 46,XX,T(11;19)(Q23;P13.3)[18]/46,XX[2], 46,XX,T(11;19)(Q23;P13.3)[24], 46,XX,T(11;19)(Q23;P13.3)[7]/46,XX[19], 46,XX,T(4;11)(Q21;Q23), 46,XX,T(4;11)(Q21;Q23)[10]/46,XX[10], 46,XX,T(4;11)(Q21;Q23)[11]/46,XX[3], 46,XX,T(4;11)(Q21;Q23)[11]/46,XX[9], 46,XX,T(4;11)(Q21;Q23)[13]/46,XX[7], 46,XX,T(4;11)(Q21;Q23)[14]/46,XX[6], 46,XX,T(4;11)(Q21;Q23)[19]/46,XX[1], 46,XX,T(4;11)(Q21;Q23)[20], 46,XX,T(4;11)(Q21;Q23)[8], 46,XX,T(4;11;14)(Q21;Q23;Q11.2)[12]/46,XX[4], 46,XX,T(9;11)(P22;Q23)[CP3]/46,XX[15], 46,XX[20], 46,XX[28], 46,XY,?INS(17;11)(Q23;Q23Q23)[20], 46,XY,ADD(4)(Q21),ADD(8)(Q24),DER(11)ADD(11)(P12)DEL(11)(Q13)[20], 46,XY,DEL(13)(Q21Q32)[6]/46,XY[14], 46,XY,DER(1)T(1;4)(P36.1;Q21),DER(4)T(1;4)(P36.1;Q21)T(4;18)(P16;P11.2),DER(11)(11PTER->11Q23::4Q21->4Q21::4P16->4PTER),DER(18)T(11;18)(Q23;P11.2)[18]/46,XY[2], 46,XY,DER(6)T(1;6)(Q25;Q15),T(11;19)(Q23;P13.3)[4]/46,XY[36], 46,XY,INS(11;4)(Q23;Q21Q23)[20], 46,XY,T(11;16)(Q23;P13.3)[17]/46,XY[4], 46,XY,T(11;19)(Q23;P13.3)[13]/46,XY[7], 46,XY,T(1;11)(P32;Q23)[8]/46,XY[12], 46,XY,T(1;11;3)(P32;Q23;P21)[4]/46,XY[20], 46,XY,T(1;19)(Q23;P13.3),-13,+MAR[13]/46,XY[7], 46,XY,T(1;9)(P32;P13),?INS(6;11)(P23;Q13Q23)[19]/46,XY[1], 46,XY,T(4;11)(11;3)(Q21;Q23P15;Q25),ADD(19)(Q13.3), 46,XY,T(4;11)(Q21;Q23), 46,XY,T(4;11)(Q21;Q23),T(14;22)(Q32;Q13)[19]/46,XY[1], 46,XY,T(4;11)(Q21;Q23)[12]/46,XY[3], 46,XY,T(4;11)(Q21;Q23)[12]/46,XY[8], 46,XY,T(4;11)(Q21;Q23)[13]/46,XY[12], 46,XY,T(4;11)(Q21;Q23)[13]/46,XY[4], 46,XY,T(4;11)(Q21;Q23)[16]/46,XY[4], 46,XY,T(4;11)(Q21;Q23)[19]/46,XY[1], 46,XY,T(4;11)(Q21;Q23)[20], 46,XY,T(4;11)(Q21;Q23)[2], 46,XY,T(4;11)(Q21;Q23)[7]/46,XY[1], 46,XY,T(4;11)(Q21;Q23)[8]/46,XY[2], 46,XY,T(4;11)(Q21;Q23)[9]/46,XY[1], 46,XY[15], 46,XY[20], 46,XY[23], 46,Y,T(X;10)(P11.2;P11.2)[7]/46,XY[13], 47,XX,+5,ADD(6)(P25),ADD(10)(P14),-11,DEL(15)(Q21),+19,DER(19)T(11;19)(Q23;P13.3)DEL(19)(Q12)[8]/46,XX[7].ISH DER(6)(MLL+),DER(19)(MLL+), 47,XX,+6,T(11;19)(Q23;P13.3)[2]/46,XX[22], 47,XXXC,T(4;11;5)(Q21;Q23;Q31)[17]/47,XXXC[1], 47,XY,+X,T(11;19)(Q23;P13.3)[10]/45,IDEM,-X,DER(7;21)(Q10;Q10)[10], 47,XY,T(4;11)(Q21;Q23),+DER(4)T(4;11)(Q21;Q23)[20], 54,XY,+X,+4,+6,+14,+17,+18,+21,+21[9]/46,XY[11]

mll_ind

MLL_G, MLL_R

mll_par

--, AF4, AF9, ASAH3, ENL, EPS15, NOT AF4, AF9 OR ENL; PARTNER UNKNOWN, NOT AF4; PARTNER UNKNOWN

organism

Homo sapiens

--, ASAH3, EPS15, NOT AF4, AF9 OR ENL; PARTNER UNKNOWN

race

AMERICAN INDIAN, Asian, Black, MORE THAN ONE RACE, OTHER, UNKNOWN, White

sample_id

609432, 609546, 611452, 611584, 611624, 611818, 612149, 612192, 612250, 612530, 612534, POG1999-01522, POG2000-00242, POG2000-00451, POG2000-00531, POG2000-00731, POG2000-01461, POG2000-02291, POG2000-03802, POG2001-04141, POG2001-05001, POG2001-09232, POG2001-11182, POG2001-14432, POG2001-14822, POG2001-17741, POG2001-22781, POG2002-06191, POG2002-07921, POG2002-15181, POG2002-16161, POG2002-17021, POG2002-22501, POG2002-22751, POG2002-24641, POG2003-00811, POG2003-01732, POG2003-02342, POG2003-04671, POG2003-05382, POG2003-05561, POG2004-04871, POG2004-05102, POG2004-07572, POG2004-08141, POG2004-15152, POG2004-17542, POG2004-17692, POG2004-22831, POG2004-24311, POG2004-26571, POG2004-27381, POG2004-28311, POG2005-00361, POG2005-01352, POG2005-01391, POG2005-01972, POG2005-02091, POG2005-03821, POG2005-04201, POG2005-04351, POG2005-08371, POG2005-09391, POG2005-10211, POG2005-12321, POG2005-12661, POG2005-13751, POG2005-14471, POG2005-14591, POG2005-14761, POG2005-14932, POG2005-16082, POG2005-16451, POG2005-16871, POG2005-17182, POG2005-18041, POG2005-18771, POG2005-20201, POG2005-20341, POG2005-20641, POG2005-21761, POG2005-22512, POG2005-22801, POG2005-23061, POG2006-02331, POG2006-04087, POG2006-04241, POG2006-04251, POG2006-04441, POG2006-05811, POG2006-06631, POG2006-09001, POG2006-10701, POG2006-10791, POG2006-10821, POG2006-11032, POG2006-11701

sex

female, male

tissue_type

BM, PBL, Pheresis

wbc_unm

101.7, 1034, 11.3, 11.7, 1117.2, 121.7, 123, 1230, 124.9, 128.2, 13.3, 133.3, 143.9, 144.08, 148.4, 15.3, 150.6, 151.2, 153, 157, 170, 174, 176, 177.7, 179.5, 18.8, 196.8, 213.4, 214, 215.4, 226, 238, 24.32, 247.16, 250, 252.9, 259, 269.52, 29.1, 290.4, 316, 350.8, 355, 37.8, 384.5, 395.6, 42.4, 42.9, 429.2, 442, 444.6, 448.8, 465.31, 48.7, 481, 487.5, 49, 492, 493, 505.4, 506.5, 520, 531, 531.3, 532, 54.4, 540, 555, 565, 577.4, 577.8, 58.7, 60.5, 63.5, 64.4, 640, 67.5, 672.3, 688.7, 700, 739, 74.1, 75, 75.4, 761.2, 77.3, 79, 8, 811.7, 82, 855.3, 86, 888, 911.6, 93.7, 98.2, 999.9

实验信息

登记号

E-GEOD-68720

GEO 编号

GSE68720

实验类型

transcription profiling by array

物种

Homo sapiens

发布日期

2015年5月12日

更新日期

2015年5月22日

提交者

Mervi Heiskanen

外部链接

ArrayExpress 原始页 NCBI GEO：GSE68720

分析服务

caArray_EXP-520: Gene Expression Profiles Predictive of Outcome and Age in Infant Acute Lymphoblastic Leukemia: a Children's Oncology Group Study

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