Investigation of the molecular mechanisms underlying of herb pair Daji and Gancao with different combination designs acting on hepatocellular carcinoma ascites mice

·发布 2016年1月20日 ·更新 2016年1月23日

样本数

实验数

芯片平台

实验描述

The differentially expressed genes among the blank control, ascites mouse model, Daji (DJ)/ Gancao (GC)-synergistic treatment and DJ/GC-antagonistic treatment groups were identified to investigate the molecular mechanisms underlying the herb pair DJ and GC acting on ascites mice. In the study, 50 male Kunming mice were randomly divided into 5 groups, namely, normal control group, model group, Daji/Gancao-synergy group, Daji/Gancao-antagonism group, Daji group. Normal control group and model group were intragastrically administrated with normal saline, while other 3 groups were intragastrically administrated with corresponding doses.

芯片平台

A-GEOD-13684

Phalanx Biotech mouse OneArray Microarray v2（15 例）

样本属性

age

4~6 weeks old

genotype

Healthy mouse, hepatocellular carcinoma (HCC) acites

intragastric administration

Euphorbia Pekinensis, Euphorbia Pekinensis:Radix Glycytthizae=1:2, Euphorbia Pekinensis:Radix Glycytthizae=1:4, normal saline

model

Healthy mouse, hepatocellular carcinoma acites

organism

Mus musculus

organism part

Peritoneal tissue

Sex

male

strain background

Kunming

treatment outcome

compare with normal control, the spirit drooping, abnormal increase of abdomen circumference and body weighr, belly tympanites, belly has ascites, compare with normal control, the spirit drooping, abnormal increase of abdomen circumference and body weight, belly tympanites, belly has ascites; as same as model., compare with normal control, the spirit drooping, abnormal increase of abdomen circumference and body weight, belly tympanites, belly has ascites; the abdomen circumference and body weight less than the mouse of Euphorbia Pekinensis group., compare with normal control, the spirit drooping, abnormal increase of abdomen circumference and body weight, belly tympanites, belly has ascites; the abdomen circumference and body weight less than the mouse of model group., normal to growth, the fur bright, good spirit

weight

18~22 g

实验信息

登记号

E-GEOD-76818

GEO 编号

GSE76818

实验类型

transcription profiling by array

物种

Mus musculus

发布日期

2016年1月20日

更新日期

2016年1月23日

提交者

Yanqiong Zhang、 Chen Yan、 Yanqiong Zhang

外部链接

ArrayExpress 原始页 NCBI GEO：GSE76818

分析服务

Investigation of the molecular mechanisms underlying of herb pair Daji and Gancao with different combination designs acting on hepatocellular carcinoma ascites mice

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