RIP4 inhibits Interleukin-6 Signaling to sustain Lung Adencarcinoma Differentiation

Evaluation of the role of RIP4 in lung adenocarcinoma revealed that RIP4 inhibits IL6 mediated STAT3 signaling in vitro and in vivo. Repression of RIP4 enhanced IL6 signaling activation in KRAS LSL/G12D/wt; p53flox/flox murine tumors. This promoted cancer dedifferentiation through ECM remodeling Investigation of transcriptional changes in KP tumors expressing shRNA against RIP4 or p53 (control) by microarray (Mouse gene 2.0 ST array from affymetrix)