Deciphering the molecular immune response to COVID-19 using single cell multi-omics

·发布 2021年3月17日

143

样本数

143

实验数

相关文献

实验描述

Multi-omics single-cell profiling of surface proteins, gene expression and lymphocyte immune receptors from hospitalised COVID-19 patient peripheral blood immune cells and healthy controls donors. Identification of the coordinated immune cell compositional and state changes in response to SARS-CoV-2 infection or LPS challenge, compared to healthy control immune cells.

参考文献

Single-cell multi-omics analysis of the immune response in COVID-19

Emily Stephenson, Gary Reynolds, Rachel A. Botting, Fernando J. Calero-Nieto, Michael D. Morgan, Zewen Kelvin Tuong, Karsten Bach, Waradon Sungnak, Kaylee B. Worlock, Masahiro Yoshida, Natsuhiko Kumasaka, Katarzyna Kania, Justin Engelbert, Bayanne Olabi, Jarmila Stremenova Spegarova, Nicola K. Wilson, Nicole Mende, Laura Jardine, Louis C. S. Gardner, Issac Goh, Dave Horsfall, Jim McGrath, Simone Webb, Michael W. Mather, Rik G. H. Lindeboom, Emma Dann, Ni Huang, Krzysztof Polanski, Elena Prigmore, Florian Gothe, Jonathan Scott, Rebecca P. Payne, Kenneth F. Baker, Aidan T. Hanrath, Ina C. D. Schim van der Loeff, Andrew S. Barr, Amada Sanchez-Gonzalez, Laura Bergamaschi, Federica Mescia, Josephine L. Barnes, Eliz Kilich, Angus de Wilton, Anita Saigal, Aarash Saleh, Sam M. Janes, Claire M. Smith, Nusayhah Gopee, Caroline Wilson, Paul Coupland, Jonathan M. Coxhead, Vladimir Yu Kiselev, Stijn van Dongen, Jaume Bacardit, Hamish W. King, Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) COVID-19 BioResource Collaboration, Anthony J. Rostron, A. John Simpson, Sophie Hambleton, Elisa Laurenti, Paul A. Lyons, Kerstin B. Meyer, Marko Z. Nikolić, Christopher J. A. Duncan, Kenneth G. C. Smith, Sarah A. Teichmann, Menna R. Clatworthy, John C. Marioni, Berthold Göttgens, Muzlifah Haniffa

PMID: 33879890

样本属性

Organism

Homo sapiens

Developmental stage

adult

Organism part

blood

Cell type

peripheral blood mononuclear cell

Individual

C-8823, C-8825, AP11, CV0200, CV0144, CV0929, C-8941, CV0128, CV0939, CV0058, C-8899, C-8910, CV0257, C-8933, CV0037, ... 105 other values

Sequence pool

AP11, MH9179827, BGCV04, MH8919233, newcastle74, MH8919327, MH9143420, MH8919227, MH8919230, MH9143270, MH8919329, MH8919330, BGCV10, MH8919177, BGCV08, ... 83 other values

Disease

COVID-19, normal

Stimulus

none, LPS

实验信息

登记号

E-MTAB-10026

实验类型

RNA-seq of coding RNA from single cells, Cell line - Single-cell sequencing

物种

Homo sapiens, Homo sapiens

发布日期

2021年3月17日

提交者

Mike Morgan

外部链接

ArrayExpress 原始页

分析服务

Deciphering the molecular immune response to COVID-19 using single cell multi-omics

联系地址

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