RNA-seq to investigate gene expression after HCV eradication with IFN therapy in HIV/HCV-coinfected patients

·发布 2021年5月5日

样本数

实验数

相关文献

实验描述

We conducted a prospective study in 28 HIV/HCV-coinfected patients receiving IFN-based therapy at baseline (HIV/HCV-b) and week 24 after the sustained virological response (HIV/HCV-f). Twenty-seven HIV-monoinfected patients (HIV-group) were included as a control group, which were effectively treated with cART (virological controlled and CD4+ T-cell counts over 500) for an extended period. RNA-seq analysis was performed on peripheral blood mononuclear cells (PBMCs).

参考文献

HCV eradication with IFN-based therapy does not completely restore gene expression in PBMCs from HIV/HCV-coinfected patients

Brochado Ó, Martínez I, Berenguer J, Medrano L, González-García J, Jiménez-Sousa MÁ, Carrero A, Hontañón V, Navarro J, Guardiola JM, Fernández-Rodríguez A, Resino S;

PMID: 33785040

样本属性

Organism

Homo sapiens

Developmental stage

adult

Organism part

blood

Cell type

peripheral blood mononuclear cell

Individual

718, 048C, 028C, 046C, 216C, 97, 234C, 37, 719, 239C, 034C, 202C, 218C, 032C, 38, ... 40 other values

Age

53 year, 57 year, 43 year, 49 year, 38 year, 36 year, 46 year, 48 year, 55 year, 52 year, 54 year, 47 year, 40 year, 45 year, 50 year, ... 3 other values

Sex

female, male

Disease

HIV-1 infection, HIV-infection and hepatitis C virus infection

Clinical history

treatment-naive, combined anti-retroviral therapy

Infect

Human immunodeficiency virus 1; Hepatitis C Virus, Human immunodeficiency virus 1

实验信息

登记号

E-MTAB-10232

实验类型

RNA-seq of coding RNA

物种

Homo sapiens, Homo sapiens

发布日期

2021年5月5日

提交者

Salvador Resino Garcia

外部链接

ArrayExpress 原始页

分析服务

RNA-seq to investigate gene expression after HCV eradication with IFN therapy in HIV/HCV-coinfected patients

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