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E-MTAB-13096 RNA-seq of coding RNA Homo sapiens, Homo sapiens

DNA sensing and Interferon Beta 1 transactivation drive radiation-induced anti-tumor immune effects in human pancreatic cancer cells

·Released Aug. 12, 2024
27
Samples
27
Assays
Description

We demonstrate that a clinically relevant X-ray hypofractionation regimen (3x8 Gy) of multiple PDAC cel lines effectively induces immunogenic cell death and transactivates Interferon beta-1 in a STING-dependent manner. RNA-seq analyses showed a global and steady upregulation of type I interferon response in PDAC cells following 3x8 Gy.

Sample Attributes
Organism
Homo sapiens
Developmental stage
adult
Organism part
pancreas, pancreatic duct
Cell line
BxPC3, PANC1, MIA-PaCa2
Disease
adenocarcinoma, pancreatic carcinoma
Experiment Info
Accession
E-MTAB-13096
Type
RNA-seq of coding RNA
Organism
Homo sapiens, Homo sapiens
Released
Aug. 12, 2024
Submitter
Vedran Franke、 Dea Slade
External Links
ArrayExpress source
Analysis Services
Analysis Services

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