Mouse cornea trasnciptomics: Pax6-sey mutation (Aniridia model) and Duloxetine administration - Affymetrix GeneChip Mouse Gene 2.0 ST Array (MoGene-2_0-st) in -

Cornea transcriptomic analysis in a mouse model of slowly progressing aniridia-associated keratopathy (AAK) the heterozygous 129S1.Cg-Pax6Sey/Mmmh strain on the 129S1/SvImJ background (MMRRC stock #050624-MU)(4, 5). The Pax6 mutation of this model is a spontaneous point mutation in exon 8 of the Pax6 gene (G to T substitution), leading to a premature stop codon. Mice were treated with 10 μM duloxetine eyedrops (samples named Het-Dul) or vehicle (Samples named Het-Veh) twice daily, for 90 days. The experimental design also included non-mutant, WT mouse eyes that were either administered with the same regimen of duloxetine (samples named Wt-Dul) or untouched (Samples names Wt-Ctrl).