Resistance to PI3K/mTOR inhibitor PF-04691502 in KRAS mutant colorectal cancer models reveals a sensitivity to combination with EGFR inhibition

提交 2013年6月30日 ·发布 2014年8月31日 ·更新 2015年6月29日

样本数

实验数

相关文献

实验描述

We explored potential bypass mechanisms to PI3K/mTOR-directed therapy in KRAS mutant CRC models, utilizing genetically engineered mouse models (GEMM) to generate acquired resistance to the targeted dual PI3K/mTOR small molecule inhibitor PF-04691502. Transcriptomic analysis revealed a dynamic stem-like progenitor signature which was increased in the presence of drug pressure.

参考文献

Resistance to dual blockade of the kinases PI3K and mTOR in KRAS-mutant colorectal cancer models results in combined sensitivity to inhibition of the receptor tyrosine kinase EGFR

Belmont PJ, Jiang P, McKee TD, Xie T, Isaacson J, Baryla NE, Roper J, Sinnamon MJ, Lee NV, Kan JL, Guicherit O, Wouters BG, O'Brien CA, Shields D, Olson P, VanArsdale T, Weinrich SL, Rejto P, Christensen JG, Fantin VR, Hung KE, Martin ES

PMID: 25389372

样本属性

disease

colorectal cancer

genotype

mutant for Apc, Kras, and p53 (AKP)

organism

Mus musculus

phenotype

parental AKP cell, PF-04691502–resistant cell

实验信息

登记号

E-MTAB-2510

GEO 编号

ERP005774

实验类型

RNA-seq of coding RNA

物种

Mus musculus

提交日期

2013年6月30日

发布日期

2014年8月31日

更新日期

2015年6月29日

提交者

Tao Xie

外部链接

ArrayExpress 原始页 NCBI GEO：ERP005774

分析服务

Resistance to PI3K/mTOR inhibitor PF-04691502 in KRAS mutant colorectal cancer models reveals a sensitivity to combination with EGFR inhibition

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