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E-MTAB-6730 methylation profiling by array Homo sapiens

Whole-genome methylation analysis (450k) of school aged children prenatally exposed to alcohol vs controls

·发布 2018年5月12日 ·更新 2018年5月2日
179
样本数
358
实验数
1
芯片平台
1
相关文献
实验描述

We tested a hypothesis that prenatal alcohol exposure may lead to epigenetic alterations to the DNA resulting in attentional and cognitive alterations of the children. 6-9 year old children school children of the Franconian Cognition and Emotion Studies (FRANCES) cohort which were tested for an objective marker of PAE, ethyl glucuronide (EtG) in meconium at birth. 32 newborns were found to be exposed to alcohol with a threshold above 30 ng/g (EtG+) but without a FAS diagnosis. DNA for methylation analysis was extracted from buccal cells, DNA methylation was analyzed using the Infinium Human Methylation 450K BeadChip array (Illumina).

参考文献
Prenatal alcohol exposure is associated with adverse cognitive effects and distinct whole-genome DNA methylation patterns in primary school children
Stefan Frey, Anna Eichler, Valeska Stonawski, Jennifer Kriebel, Simone Wahl, Sabina Gallati, Tamme W. Goecke, Peter A. Fasching, Matthias W. Beckmann, Oliver Kratz, Gunther H. Moll, Hartmut Heinrich, Johannes Kornhuber, Yulia Golub
芯片平台
A-MEXP-2255
Illumina Infinium HumanMethylation450 BeadChip(358 例)
样本属性
age
6 year, 6,166666667 year, 6,416666667 year, 6,5 year, 6,583333333 year, 6,666666667 year, 6,75 year, 6,833333333 year, 6,916666667 year, 7 year, 7,083333333 year, 7,166666667 year, 7,25 year, 7,333333333 year, 7,416666667 year, 7,5 year, 7,583333333 year, 7,666666667 year, 7,75 year, 7,833333333 year, 7,916666667 year, 8 year, 8,083333333 year, 8,166666667 year, 8,25 year, 8,333333333 year, 8,416666667 year, 8,5 year, 8,666666667 year, 8,75 year, 8,833333333 year, 8,916666667 year, 9 year, 9,083333333 year, 9,166666667 year, 9,25 year, 9,333333333 year
birth weight
2090 gram, 2140 gram, 2280 gram, 2470 gram, 2500 gram, 2510 gram, 2556 gram, 2570 gram, 2610 gram, 2670 gram, 2725 gram, 2750 gram, 2760 gram, 2765 gram, 2800 gram, 2830 gram, 2850 gram, 2870 gram, 2880 gram, 2890 gram, 2900 gram, 2915 gram, 2950 gram, 2970 gram, 2975 gram, 2980 gram, 2985 gram, 2990 gram, 3000 gram, 3010 gram, 3060 gram, 3080 gram, 3100 gram, 3110 gram, 3130 gram, 3150 gram, 3160 gram, 3170 gram, 3180 gram, 3200 gram, 3210 gram, 3230 gram, 3250 gram, 3260 gram, 3270 gram, 3280 gram, 3300 gram, 3310 gram, 3320 gram, 3330 gram, 3350 gram, 3360 gram, 3370 gram, 3380 gram, 3390 gram, 3400 gram, 3410 gram, 3430 gram, 3440 gram, 3450 gram, 3480 gram, 3490 gram, 3500 gram, 3520 gram, 3550 gram, 3560 gram, 3570 gram, 3580 gram, 3600 gram, 3610 gram, 3640 gram, 3650 gram, 3670 gram, 3680 gram, 3700 gram, 3720 gram, 3725 gram, 3730 gram, 3750 gram, 3780 gram, 3800 gram, 3820 gram, 3830 gram, 3860 gram, 3880 gram, 3890 gram, 3900 gram, 3920 gram, 3945 gram, 4000 gram, 4010 gram, 4020 gram, 4040 gram, 4050 gram, 4070 gram, 4110 gram, 4120 gram, 4130 gram, 4170 gram, 4180 gram, 4230 gram, 4250 gram, 4270 gram, 4280 gram, 4350 gram, 4420 gram, 4440 gram, 4640 gram, 4650 gram, 4900 gram
cell type
buccal mucosa cell
disease
normal
IQ score
IQ score 100, IQ score 101, IQ score 102, IQ score 103, IQ score 104, IQ score 105, IQ score 106, IQ score 107, IQ score 108, IQ score 109, IQ score 110, IQ score 111, IQ score 112, IQ score 113, IQ score 114, IQ score 115, IQ score 116, IQ score 117, IQ score 119, IQ score 120, IQ score 122, IQ score 123, IQ score 125, IQ score 75, IQ score 77, IQ score 78, IQ score 82, IQ score 83, IQ score 84, IQ score 86, IQ score 88, IQ score 89, IQ score 90, IQ score 91, IQ score 93, IQ score 94, IQ score 95, IQ score 96, IQ score 97, IQ score 98, IQ score 99
organism
Homo sapiens
organism part
mouth mucosa
ses score
SES score 10, SES score 11, SES score 12, SES score 13, SES score 14, SES score 6, SES score 7, SES score 8, SES score 9
sex
female, male
实验信息
登记号
E-MTAB-6730
实验类型
methylation profiling by array
物种
Homo sapiens
发布日期
2018年5月12日
更新日期
2018年5月2日
提交者
Stefan Frey
分析服务
分析服务

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