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E-MTAB-6830 ERP109062 RNA-seq of coding RNA Homo sapiens

Expression profiling of pancreatic ductal adenocarcinoma

提交 2018年5月10日 ·发布 2020年1月25日 ·更新 2020年1月25日
104
样本数
104
实验数
1
相关文献
实验描述

Pancreatic ductal adenocarcinoma (PDAC) has the worst prognosis of all common cancers, but divergent outcomes are apparent between patients. To delineate the intertumor heterogeneity that contributes to this, we aimed to identify clinically distinct gene expression-based subgroups. From a cohort of 345 resected pancreatic cancer cases, 90 samples with confirmed diagnosis of PDAC and sufficient tumor content were available for gene expression analysis by RNA sequencing. Unsupervised classification was applied, and a classifier was constructed. Species-specific transcript analysis on matching patient-derived xenografts (PDX, N=14) allowed construction of tumor- and stroma-specific classifiers for use on PDX models and cell lines.

参考文献
Unsupervised class discovery in pancreatic ductal adenocarcinoma reveals cell-intrinsic mesenchymal features and high concordance between existing classification systems.
Dijk F, Veenstra VL, Soer EC, Dings MPG, Zhao L, Halfwerk JB, Hooijer GK, Damhofer H, Marzano M, Steins A, Waasdorp C, Busch OR, Besselink MG, Tol JA, Welling L, van Rijssen LB, Klompmaker S, Wilmink HW, van Laarhoven HW, Medema JP, Vermeulen L, van Hooff SR, Koster J, Verheij J, van de Vijver MJ, Wang X, Bijlsma MF.
PMID: 31941932
样本属性
age
44 year, 48 year, 49 year, 51 year, 52 year, 53 year, 54 year, 55 year, 57 year, 59 year, 60 year, 61 year, 62 year, 63 year, 64 year, 65 year, 66 year, 67 year, 68 year, 69 year, 70 year, 71 year, 72 year, 73 year, 74 year, 75 year, 76 year, 78 year, 79 year, 80 year, 81 year, 83 year
differentiation grade
moderate, poor, unknown, well
disease
pancreatic ductal adenocarcinoma
individual
hha101, hha102, hha105, hha109, hha115, hha123, hha126, hha127, hha13, hha135, hha136, hha138, hha142, hha145, hha151, hha158, hha16, hha164, hha170, hha173, hha18, hha180, hha182, hha184, hha187, hha19, hha190, hha195, hha198, hha2, hha20, hha205, hha214, hha218, hha219, hha22, hha220, hha221, hha229, hha234, hha236, hha238, hha242, hha244, hha246, hha249, hha250, hha252, hha26, hha266, hha267, hha270, hha273, hha28, hha285, hha289, hha291, hha295, hha296, hha298, hha3, hha30, hha300, hha302, hha303, hha306, hha307, hha33, hha35, hha37, hha4, hha44, hha5, hha59, hha64, hha67, hha72, hha73, hha74, hha75, hha76, hha81, hha83, hha84, hha86, hha88, hha90, hha92, hha96, hha98, pdx_053M, pdx_053Tb, pdx_103, pdx_112, pdx_117, pdx_67, pdx_72, pdx_76, pdx_84, pdx_86, pdx_90, pdx_93, pdx_96, pdx_99
lymph node metastasis ratio
0, 0.04, 0.06, 0.07, 0.11, 0.12, 0.13, 0.14, 0.15, 0.17, 0.18, 0.19, 0.2, 0.21, 0.22, 0.24, 0.25, 0.27, 0.28, 0.3, 0.31, 0.33, 0.35, 0.38, 0.4, 0.43, 0.44, 0.45, 0.5, 0.57, 0.83, 0.88, 1
organism
Homo sapiens
organism part
pancreas
organism status
alive, dead
overall survival
10.12 month, 10.48 month, 10.78 month, 11.01 month, 11.17 month, 11.27 month, 11.5 month, 11.93 month, 119.85 month, 12.02 month, 12.22 month, 12.29 month, 12.45 month, 14 month, 14.52 month, 14.69 month, 15.01 month, 15.44 month, 15.7 month, 16.2 month, 16.33 month, 16.49 month, 16.66 month, 16.85 month, 17.08 month, 17.41 month, 17.64 month, 18.07 month, 18.5 month, 19.78 month, 2.04 month, 2.17 month, 21.32 month, 21.45 month, 21.49 month, 21.52 month, 22.93 month, 24.84 month, 26.18 month, 27.01 month, 28.98 month, 29.04 month, 29.17 month, 30.19 month, 30.82 month, 31.74 month, 31.77 month, 31.8 month, 32.03 month, 33.18 month, 33.71 month, 36.6 month, 37.06 month, 37.72 month, 39.33 month, 43.01 month, 5.49 month, 5.78 month, 51.84 month, 52.5 month, 52.83 month, 56.97 month, 58.25 month, 6.01 month, 6.67 month, 65.41 month, 68.11 month, 7.39 month, 7.98 month, 71.23 month, 8.02 month, 8.08 month, 8.21 month, 8.31 month, 8.41 month, 8.77 month, 8.84 month, 81.48 month, 89.1 month, 9.43 month, 9.59 month, 9.89 month, 91.5 month, 95.38 month, 95.44 month
radicality
R0-microscopically radical,marge >=1mm, R1-microscopically irradical, marge <1 mm or tumor in resection margin
sex
female, male
xenograft
pancreatic cancer cells grown in nude mouse
实验信息
登记号
E-MTAB-6830
GEO 编号
ERP109062
实验类型
RNA-seq of coding RNA
物种
Homo sapiens
提交日期
2018年5月10日
发布日期
2020年1月25日
更新日期
2020年1月25日
提交者
Maarten F. Bijlsma、 Hao Huang
分析服务
分析服务

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