Genome-wide methylation profiling of sporadic Pancreatic Neuroendocrine Tumors

·发布 2020年11月30日

样本数

120

实验数

芯片平台

实验描述

Pancreatic neuroendocrine tumors (PanNETs) account for 1-3% of all neoplasms of the pancreas. Epigenetic changes seem to be the main drivers of PanNET tumorigenesis. Indeed, the most frequent mutated genes in PanNETs are DAXX (Death domain associated protein 6), ATRX (Transcriptional Regulator ATRX) and MEN1 (menin 1), which are all involved in epigenetic regulation. The objective of the project is to study the epigenetic changes undergoing in PanNETs. Specifically, we aimed at investigating whether do exist biologically important epigenetic differences in PanNET, useful for a clinically relevant classification.

芯片平台

A-MEXP-2255

Illumina Infinium HumanMethylation450 BeadChip（120 例）

样本属性

Organism

Homo sapiens

Developmental stage

adult

Patientcase

34, 30, 72, 74, 71, 50, 65, 44, 46, 13, 23, 62, 48, 4, 49, ... 37 other values

Age

58 year, 69 year, 45 year, 62 year, 32 year, 49 year, 60 year, 72 year, 35 year, 53 year, not available, 54 year, 56 year, 59 year, 40 year, ... 17 other values

Sex

male, female, NA

Organism part

endocrine pancreas, pancreas

Disease

normal, pancreatic neuroendocrine tumor

Daxx/atrx status ihc

ATRX loss, not available, DAXX loss, no DAXX or ATRX loss, not applicable

Men1 ngs

wild type men1, mutant men1, not applicable

Alt telo-fish

positive, not available, negative, not applicable

Individual

UCL69, UCL24, UB21, ... 57 other values

实验信息

登记号

E-MTAB-7924

实验类型

Human - Methylation microarray, methylation profiling by array

物种

Homo sapiens, Homo sapiens

发布日期

2020年11月30日

提交者

Annunziata Di Domenico、 Ilaria Marinoni、 Aurel Perren、 Chrissie Thirlwell

外部链接

ArrayExpress 原始页

分析服务

Genome-wide methylation profiling of sporadic Pancreatic Neuroendocrine Tumors

联系地址

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