1, 3-Dicaffeoylquinic acid targeting 14-3-3 τ suppresses human breast cancer cell proliferation and metastasis through IL6/JAK2/PI3K pathway

Caffeoylquinic acids are a kind of phenolic acid, a natural component of quinine acids. A number of caffeic acids, which are widely found in plants, are connected by ester bonds. In classic Chinese medicines, including honeysuckle, Eucommia ulmoides and white flower ginseng, caffeoylquinic acids have been identified as a main effective component that exhibits antioxidant, anti-inflammatory, antibacterial and antiviral activities . Studies have shown that some dicaffeoylquinic acids have significant inhibitory effects on melanoma, colorectal cancer, gastric cancer, breast cancer and many other tumours . The development and exploration of the pharmacodynamic effects of dicaffeoylquinic acids will become another hot topic in the development of new drugs.