ACTBP11（Actin Binding Protein 11）是一种与肌动蛋白结合的蛋白质，主要参与细胞骨架的动态调节和细胞运动。它在细胞形态维持、迁移、分裂以及细胞内物质运输中发挥重要作用。ACTBP11通过结合肌动蛋白纤维调控其聚合和解聚，从而影响细胞骨架的重排。该基因在多种组织中表达，尤其在肌肉、神经和上皮细胞中表达较高。突变可能导致细胞骨架功能紊乱，影响细胞运动性和形态，进而与某些癌症（如乳腺癌和结肠癌）的转移相关，也可能导致神经发育异常或肌肉功能障碍。若ACTBP11过表达，可能增强细胞迁移能力，促进肿瘤侵袭；而表达降低则可能导致细胞骨架稳定性下降，影响细胞正常功能。ACTBP11属于肌动蛋白结合蛋白家族，该家族成员均含有保守的肌动蛋白结合域，能够调控肌动蛋白的动态组装，参与细胞运动、形态变化和信号传导等过程。这一家族的蛋白质通常通过与其他细胞骨架蛋白或信号分子相互作用，协调复杂的细胞活动。

ACTBP11, a member of the actin-binding protein family, functions as a critical regulator of the cytoskeletal dynamics essential for maintaining cellular integrity and facilitating motility. By interacting with actin filaments through conserved binding domains, ACTBP11 modulates the balance between actin polymerization and depolymerization, thereby governing the structural reorganization required for cell shape maintenance, migration, division, and intracellular transport. This protein operates within a broader network of cytoskeletal and signaling molecules, coordinating complex cellular activities that underpin tissue homeostasis. While expressed across various tissues, ACTBP11 shows particularly high levels in muscle, neural, and epithelial cells, reflecting its specialized roles in these contexts. Dysregulation of ACTBP11 expression has significant pathological implications; overexpression can enhance cell migratory capacity and promote tumor invasion, contributing to the metastatic progression of cancers such as breast and colorectal carcinoma, whereas reduced expression may compromise cytoskeletal stability and impair normal cellular functions. Furthermore, mutations or aberrant expression of ACTBP11 are linked to broader physiological disturbances, including neurodevelopmental abnormalities and muscular dysfunction, underscoring its vital role in the structural and functional coherence of diverse tissue types.

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