ALDOC (aldolase, fructose-bisphosphate C)

Gene Basic Information

Gene Basic Information

symbol
ALDOC
locus group
protein-coding gene
location
17q11.2
gene_family
-
alias symbol
-
alias name
None
entrez id
230
ensembl gene id
ENSG00000109107
ucsc gene id
uc002hbp.4
refseq accession
NM_005165
hgnc_id
HGNC:418
approved reserved
1986-01-01

Chromosome Location

Chromosome Location

17q11.2

Gene Summary

Gene Summary

ChineseEnglish

This gene encodes a member of the class I fructose-biphosphate aldolase gene family. Expressed specifically in the hippocampus and Purkinje cells of the brain, the encoded protein is a glycolytic enzyme that catalyzes the reversible aldol cleavage of fructose-1,6-biphosphate and fructose 1-phosphate to dihydroxyacetone phosphate and either glyceraldehyde-3-phosphate or glyceraldehyde, respectively. [provided by RefSeq, Jul 2008]

OMIM entry for ALDOC     Wikipedia entry for ALDOC

Gene Sequence

Gene Sequence

Nucleotide sequence of ALDOC:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MPHSYPALSA EQKKELSDIA LRIVAPGKGI LAADESVGSM
41AKRLSQIGVE NTEENRRLYR QVLFSADDRV KKCIGGVIFF
81 HETLYQKDD NGVPFVRTIQ DKGIVVGIKV DKGVVPLAGT
121DGETTTQGLD GLSERCAQYK KDGADFAKWR CVLKISERTP
161S ALAILENA NVLARYASIC QQNGIVPIVE PEILPDGDHD
201LKRCQYVTEK VLAAVYKALS DHHVYLEGTL LKPNMVTPGH
241AC PIKYTPE EIAMATVTAL RRTVPPAVPG VTFLSGGQSE
281EEASFNLNAI NRCPLPRPWA LTFSYGRALQ ASALNAWRGQ
321RDN AGAATE EFIKRAEVNG LAAQGKYEGS GEDGGAAAQS
361LYIANHAY
Structure predicted by AlphaFold DB(UniProt: P09972). Color indicates pLDDT confidence (dark blue = high, yellow/orange = low).

Gene Variants

Gene Variants

SNP variants of ALDOC:           Showing partial SNPs
rs577451       rs652677       rs2228419       rs2229541       rs3132813       rs11559066       rs11870715       rs34165301       rs34236636       rs34703826       rs41280130       rs41315970       rs62066788       rs73278558       rs74902288       rs77233824       rs79130595      

Gene Expression

Gene Expression

Tissue expression of ALDOC:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
CTCTACCAGAAAGATGATAATGGTG
59
CCTTGTCAACCTTGATGCC
59
ACCATCATGTATACCTGGAGG
59
GACAGGAAGGTCACTCCTG
59
GCATCAAGGTTGACAAGGG
59
GTTCTGAGAGCCCATCCAG
60
GTATCTGCCAGCAGAATGG
58
CTGACAACGTTTGAGGTCG
59
GCATCAAGGTTGACAAGGG
59
GTTCTGAGAGCCCATCCAG
60
GATGAGTCTGTAGGCAGCA
59
TCATCAGCACTGAACAGGA
59
GTATCTGCCAGCAGAATGG
58
CTGACAACGTTTGAGGTCG
59
GCATCAAGGTTGACAAGGG
59
GTTCTGAGAGCCCATCCAG
60
GATGAGTCTGTAGGCAGCA
59
TCATCAGCACTGAACAGGA
58
GCATCAAGGTTGACAAGGG
59
GTTCTGAGAGCCCATCCAG
60

Gene Ontology

Subcellular localization of ALDOC (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for ALDOC:

GO ID
Protein
Source DB
GO:0004332
A8MVZ9 (UniProtKB)
IEA
GO:0006096
A8MVZ9 (UniProtKB)
IEA
GO:0004332
C9J8F3 (UniProtKB)
IEA
GO:0006096
C9J8F3 (UniProtKB)
IEA
GO:0004332
J3KSV6 (UniProtKB)
IEA
GO:0006096
J3KSV6 (UniProtKB)
IEA
GO:0004332
J3QKK1 (UniProtKB)
IEA
GO:0006096
J3QKK1 (UniProtKB)
IEA
GO:0004332
J3QKP5 (UniProtKB)
IEA
GO:0006096
J3QKP5 (UniProtKB)
IEA
GO:0004332
K7EKH5 (UniProtKB)
IEA
GO:0006096
K7EKH5 (UniProtKB)
IEA
GO:0004332
P09972 (UniProtKB)
IDA
GO:0004332
P09972 (UniProtKB)
EXP
GO:0004332
P09972 (UniProtKB)
IDA
GO:0005515
P09972 (UniProtKB)
IPI
GO:0005515
P09972 (UniProtKB)
IPI
GO:0005515
P09972 (UniProtKB)
IPI
GO:0005739
P09972 (UniProtKB)
IEA
GO:0005829
P09972 (UniProtKB)
TAS
GO:0005829
P09972 (UniProtKB)
TAS
GO:0005856
P09972 (UniProtKB)
IC
GO:0006000
P09972 (UniProtKB)
TAS
GO:0006094
P09972 (UniProtKB)
TAS
GO:0008092
P09972 (UniProtKB)
IDA
GO:0030388
P09972 (UniProtKB)
IDA
GO:0030388
P09972 (UniProtKB)
IDA
GO:0030855
P09972 (UniProtKB)
IEP
GO:0061621
P09972 (UniProtKB)
TAS
GO:0070062
P09972 (UniProtKB)
IDA
GO:0070062
P09972 (UniProtKB)
IDA
GO:0070062
P09972 (UniProtKB)
IDA
GO:0070062
P09972 (UniProtKB)
IDA

Related microRNA

Related microRNA

microRNAs potentially regulating ALDOC:     

Gene Interactions

Gene Interactions

String
BioGrid
IntAct
mentha
Reactome
Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Borna Disease 0.08 1 0 RGD
Liver carcinoma 0.08 1 0 RGD
Schizophrenia 0.0054487 2 0 LHGDN
Central neuroblastoma 0.000271442 1 0 BeFree
Neuroblastoma 0.000271442 1 0 BeFree

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