APC2 (APC regulator of WNT signaling pathway 2)

基因基本信息

基因基本信息

symbol:
APC2
locus group:
protein-coding gene
location:
19p13.3
gene_family:
Armadillo repeat containing
alias symbol:
APCL
alias name:
adenomatous polyposis coli like
entrez id:
10297
ensembl gene id:
ENSG00000115266
ucsc gene id:
uc002lsr.1
refseq accession:
NM_005883
hgnc_id:
HGNC:24036
approved reserved:
2004-03-18

基因染色体位置

基因染色体位置

19p13.3

基因简述

基因简述

APC2（Adenomatous Polyposis Coli 2）是APC基因家族的成员之一，与著名的肿瘤抑制基因APC（APC1）同源。APC基因家族的主要共性是参与Wnt信号通路的调控，通过促进β-catenin的降解来抑制细胞过度增殖，从而维持组织稳态。APC2主要在神经系统中高表达，尤其在发育中的大脑皮层和海马区，其蛋白产物通过与微管结合参与细胞骨架的组装和神经元迁移，对大脑发育至关重要。APC2还能与APC1协同作用，通过结合轴蛋白（Axin）和糖原合成酶激酶3β（GSK3β）形成“破坏复合体”，促使β-catenin磷酸化并降解，从而阻断Wnt信号通路的异常激活。若APC2发生功能丧失性突变，可能导致β-catenin积累，引发Wnt信号过度活跃，与神经发育障碍如自闭症谱系障碍（ASD）和智力障碍相关。此外，APC2突变还与某些癌症（如胶质瘤）的发生有关，但相比APC1在结直肠癌中的明确作用，APC2的致癌机制尚不清晰。当APC2过表达时，可能过度抑制Wnt通路，影响神经元的正常分化和突触可塑性；而表达降低则可能导致神经迁移缺陷或异常细胞增殖。研究还发现APC2与精神分裂症风险基因DISC1存在相互作用，共同调节神经元形态发生。尽管APC2与APC1功能部分重叠，但APC2在神经系统中的特异性作用使其成为神经发育和退行性疾病研究的重要靶点。

中文English

无

OMIM数据库中对APC2基因的介绍     Wikipedia数据库中对APC2基因的介绍

基因序列

基因序列

APC2基因的碱基序列：[NCBI]
Loading Gene Browser...

编码蛋白质

编码蛋白质

蛋白质序列
1MASSVAPYEQ LVRQVEALKA ENSHLRQELR DNSSHLSKLE
41TETSGMKEVL KHLQGKLEQE ARVLVSSGQT EVLEQLKALQ
81 MDITSLYNL KFQPPTLGPE PAARTPEGSP VHGSGPSKDS
121FGELSRATIR LLEELDRERC FLLNEIEKEE KEKLWYYSQL
161Q GLSKRLDE LPHVETQFSM QMDLIRQQLE FEAQHIRSLM
201EERFGTSDEM VQRAQIRASR LEQIDKELLE AQDRVQQTEP
241QA LLAVKSV PVDEDPETEV PTHPEDGTPQ PGNSKVEVVF
281WLLSMLATRD QEDTARTLLA MSSSPESCVA MRRSGCLPLL
321LQI LHGTEA AAGGRAGAPG APGAKDARMR ANAALHNIVF
361SQPDQGLARK EMRVLHVLEQ IRAYCETCWD WLQARDGGPE
401GGGA GSAPI PIEPQICQAT CAVMKLSFDE EYRRAMNELG
441GLQAVAELLQ VDYEMHKMTR DPLNLALRRY AGMTLTNLTF
481GDVAN KATL CARRGCMEAI VAQLASDSEE LHQVVSSILR
521NLSWRADINS KKVLREAGSV TALVQCVLRA TKESTLKSVL
561SALWNL SAH STENKAAICQ VDGALGFLVS TLTYKCQSNS
601LAIIESGGGI LRNVSSLVAT REDYRQVLRD HNCLQTLLQH
641LTSHSLT IV SNACGTLWNL SARSARDQEL LWDLGAVGML
681RNLVHSKHKM IAMGSAAALR NLLAHRPAKH QAAATAVSPG
721SCVPSLYV R KQRALEAELD ARHLAQALEH LEKQGPPAAE
761AATKKPLPPL RHLDGLAQDY ASDSGCFDDD DAPSSLAAAA
801ATGEPASPA ALSLFLGSPF LQGQALARTP PTRRGGKEAE
841KDTSGEAAVA AKAKAKLALA VARIDQLVED ISALHTSSDD
881SFSLSSGDPG QEAPREGRA QSCSPCRGPE GGRREAGSRA
921HPLLRLKAAH ASLSNDSLNS GSASDGYCPR EHMLPCPLAA
961LASRREDPRC G QPRPSRLD LDLPGCQAEP PAREATSADA
1001RVRTIKLSPT YQHVPLLEGA SRAGAEPLAG PGISPGARKQ
1041AWLPADHLSK VP EKLAAAP LSVASKALQK LAAQEGPLSL
1081SRCSSLSSLS SAGRPGPSEG GDLDDSDSSL EGLEEAGPSE
1121AELDSTWRAP GAT SLPVAI PAPRRNRGRG LGVEDATPSS
1161SSENYVQETP LVLSRCSSVS SLGSFESPSI ASSIPSEPCS
1201GQGSGTISPS ELPD SPGQT MPPSRSKTPP LAPAPQGPPE
1241ATQFSLQWES YVKRFLDIAD CRERCRLPSE LDAGSVRFTV
1281EKPDENFSCA SSLSA LALH EHYVQQDVEL RLLPSACPER
1321GGGAGGAGLH FAGHRRREEG PAPTGSRPRG AADQELELLR
1361ECLGAAVPAR LRKVAS ALV PGRRALPVPV YMLVPAPAPA
1401QEDDSCTDSA EGTPVNFSSA ASLSDETLQG PPRDQPGGPA
1441GRQRPTGRPT SARQAMG HR HKAGGAGRSA EQSRGAGKNR
1481AGLELPLGRP PSAPADKDGS KPGRTRGDGA LQSLCLTTPT
1521EEAVYCFYGN DSDEEPPA A APTPTHRRTS AIPRAFTRER
1561PQGRKEAPAP SKAAPAAPPP ARTQPSLIAD ETPPCYSLSS
1601SASSLSEPEP SEPPAVHPR GREPAVTKDP GPGGGRDSSP
1641SPRAAEELLQ RCISSALPRR RPPVSGLRRR KPRATRLDER
1681PAEGSRERGE EAAGSDRASD LDSVEWRAI QEGANSIVTW
1721LHQAAAATRE ASSESDSILS FVSGLSVGST LQPPKHRKGR
1761QAEGEMGSAR RPEKRGAASV K TSGSPRSP AGPEKPRGTQ
1801KTTPGVPAVL RGRTVIYVPS PAPRAQPKGT PGPRATPRKV
1841APPCLAQPAA PAKVPSPGQQ RS RSLHRPA KTSELATLSQ
1881PPRSATPPAR LAKTPSSSSS QTSPASQPLP RKRPPVTQAA
1921GALPGPGASP VPKTPARTLL AKQ HKTQRS PVRIPFMQRP
1961ARRGPPPLAR AVPEPGPRGR AGTEAGPGAR GGRLGLVRVA
2001SALSSGSESS DRSGFRRQLT FIKE SPGLR RRRSELSSAE
2041SAASAPQGAS PRRGRPALPA VFLCSSRCEE LRAAPRQGPA
2081PARQRPPAAR PSPGERPARR TTSES PSRL PVRAPAARPE
2121TVKRYASLPH ISVARRPDGA VPAAPASADA ARRSSDGEPR
2161PLPRVAAPGT TWRRIRDEDV PHILRS TLP ATALPLRGST
2201PEDAPAGPPP RKTSDAVVQT EEVAAPKTNS STSPSLETRE
2241PPGAPAGGQL SLLGSDVDGP SLAKAPI SA PFVHEGLGVA
2281VGGFPASRHG SPSRSARVPP FNYVPSPMVV AATTDSAAEK
2321APATASATLL E
结构预测来自 AlphaFold DB（UniProt: O95996），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

基因突变

基因突变

APC2基因的碱基突变：           仅显示部分snp
rs12005       rs166452       rs166453       rs182043       rs265269       rs265272       rs265273       rs265274       rs265275       rs265276       rs265277       rs265278       rs265297       rs265298       rs265299       rs791459       rs796928      

基因表达

基因表达

APC2基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
CTTGAAGGCTGAGAACAGC
59
TTCAGGACCTCCTTCATGC
59
CTTGAAGGCTGAGAACAGC
59
TTCAGGACCTCCTTCATGC
59
CTTGAAGGCTGAGAACAGC
59
TTCAGGACCTCCTTCATGC
59
CTTGAAGGCTGAGAACAGC
59
TTCAGGACCTCCTTCATGC
59
GAAGCTCTGGTACTACTCTCAG
60
TCTGCATCGAGAACGTCTC
60
GAAGCTCTGGTACTACTCTCAG
60
TCTGCATCGAGAACGTCTC
60
CTTGAAGGCTGAGAACAGC
59
TTCAGGACCTCCTTCATGC
59
GAAGCTCTGGTACTACTCTCAG
60
TCTGCATCGAGAACGTCTC
60
GCTCTGGTACTACTCTCAGC
59
CATCTGCATCGAGAACGTC
59
GGTCCTGAAGCACCTACAG
60
CCATCTGTAGGGCCTTCAG
60

转录因子

转录因子

      尚未收录相关数据

基因本体信息

APC2基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

APC2基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0008013
A0A0C4DGQ0 (UniProtKB)
IEA
GO:0090090
A0A0C4DGQ0 (UniProtKB)
IEA
GO:0008013
B5MDS5 (UniProtKB)
IEA
GO:0090090
B5MDS5 (UniProtKB)
IEA
GO:0008013
K7ELQ3 (UniProtKB)
IEA
GO:0030178
K7ELQ3 (UniProtKB)
IEA
GO:0008013
K7EN62 (UniProtKB)
IEA
GO:0030178
K7EN62 (UniProtKB)
IEA
GO:0008013
K7ERC5 (UniProtKB)
IEA
GO:0030178
K7ERC5 (UniProtKB)
IEA
GO:0001708
O95996 (UniProtKB)
IBA
GO:0005515
O95996 (UniProtKB)
IPI
GO:0005515
O95996 (UniProtKB)
IPI
GO:0005515
O95996 (UniProtKB)
IPI
GO:0005515
O95996 (UniProtKB)
IPI
GO:0005515
O95996 (UniProtKB)
IPI
GO:0005737
O95996 (UniProtKB)
IDA
GO:0005794
O95996 (UniProtKB)
IDA
GO:0005884
O95996 (UniProtKB)
IDA
GO:0007026
O95996 (UniProtKB)
IBA
GO:0007389
O95996 (UniProtKB)
IBA
GO:0008013
O95996 (UniProtKB)
IDA
GO:0008017
O95996 (UniProtKB)
IEA
GO:0008283
O95996 (UniProtKB)
IBA
GO:0015630
O95996 (UniProtKB)
IDA
GO:0016055
O95996 (UniProtKB)
IEA
GO:0016342
O95996 (UniProtKB)
IDA
GO:0016477
O95996 (UniProtKB)
IBA
GO:0030877
O95996 (UniProtKB)
IBA
GO:0031258
O95996 (UniProtKB)
IDA
GO:0035414
O95996 (UniProtKB)
IDA
GO:0045295
O95996 (UniProtKB)
IBA
GO:0045595
O95996 (UniProtKB)
IBA
GO:0045732
O95996 (UniProtKB)
IBA
GO:0048471
O95996 (UniProtKB)
IDA
GO:0048471
O95996 (UniProtKB)
IDA
GO:0048471
O95996 (UniProtKB)
IDA
GO:0090090
O95996 (UniProtKB)
IDA
GO:0090090
O95996 (UniProtKB)
IDA
GO:0005881
O95996 (UniProtKB)
IDA
GO:0005881
O95996 (UniProtKB)
IDA

基因相关microRNA

基因相关microRNA

可能调控 APC2基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

String
BioGrid
IntAct
mentha
加载中…
关联基因 作用方式 资源库来源/分值

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Mammary Neoplasms 0.12 1 0 CTD_human
Inflammatory Bowel Diseases 0.12 1 0 CTD_human
Sotos' syndrome 0.12 0 0 ORPHANET
Colorectal Neoplasms 0.12 3 0 CTD_human
Adenomatous Polyposis Coli 0.004895885 9 0 BeFree_LHGDN
Malignant tumor of colon 0.000542884 2 0 BeFree
Colon Carcinoma 0.000542884 2 0 BeFree
Retinoblastoma 0.000271442 1 0 BeFree
Ovarian Carcinoma 0.000271442 1 0 BeFree
Adenocarcinoma 0.000271442 1 0 BeFree

基因相关文献

基因相关文献

Human papillomavirus16 E7 enhances cell stemness by regulating the APC2/SPIN4/β-catenin axis in cervical cancer.
Shen T, Ma Y, Wu T, Cao Z, Yi P, Huang X, Yang S Oncogenesis IF: 6.0 2026-02-24
Examination under anesthesia in anterior posterior compression pelvic ring injuries; additional assessment of the posterior pelvic ring reveals occult sacroiliac joint instability.
Therrien CC, Ten Duis K, Banierink H, de Vries JPM, Reininga IHF, IJpma FFA Eur J Trauma Emerg Surg IF: 2.3 2026-02-09
BubR1 TPR domain supports the mitotic checkpoint by promoting MCC formation and MCC-APC/C interaction.
Zhang M, Lei T, Wang Y, Li M, Wang Y, Fang J, Zhang G Commun Biol 2026-07-20
Examination under anesthesia imaging changes surgeons' classification and treatment decisions of anterior posterior compression pelvic ring injuries.
Therrien CC, Ten Duis K, Aprato A, Banierink H, Bastian JD, Höch A, Mezzadri UMR, van Oldenrijk J, Pieroh P, Sagi HC, de Vries JPM, Reininga IHF, IJpma FFA, Society of European Pelvic and Acetabulum Surgeons Eur J Orthop Surg Traumatol IF: 1.7 2026-05-30
Construction of an actin cytoskeleton-related gene signature for predicting prognosis and therapeutic response in glioblastoma: based on machine learning.
Li M, Li J, Li Z, Liu G, Zhou Y, Meng M, Chai Z, Yuan Y, Wang C, Fu X, Ma C Transl Cancer Res IF: 2.1 2026-04-30
Suramin Interactions Across Biological Systems: From Molecular Targets to Therapeutic Implications.
Catalano A, Scaglione V, Sgobba MN, Ferrone L, Francavilla AL, Cavalluzzi MM, Todisco S, Guerra L, Volpicella M, De Grassi A, Lentini G, Pierri CL Biomolecules 2026-04-01
Functional status and health-related quality of life following Young and Burgess classified pelvic ring injuries.
Therrien CC, Uil M, Ten Duis K, Banierink H, Meesters AML, Trouwborst NM, Hamminga AJ, de Vries JPM, IJpma FFA, Reininga IHF PLoS One IF: 2.6 None
Open Book on the Water Slide: A Case Series of APC2 Pelvic Ring Injuries from High-Energy Aquatic Accidents.
Algaith A, Soni K, Mácsai A, Sándor L, Csonka Á, Varga E, Hartmann P J Clin Med 2026-02-25
Mutation Severity of FBXO43 Determines Spermatogenic Outcome and Informs Precision ART Strategies.
Xiao Y, He Y, Meng L, Zhang H, Tu C, Tan Y, Hu L Hum Mutat IF: 1.8 None

基因相关服务

基因相关服务

基因相关评论

基因相关评论

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