AMBP (alpha-1-microglobulin/bikunin precursor)

Gene Basic Information

Gene Basic Information

symbol
AMBP
locus group
protein-coding gene
location
9q32
gene_family
Lipocalins
alias symbol
UTI|HCP|EDC1|HI30|IATIL|ITILC
alias name
growth-inhibiting protein 19|urist…
entrez id
259
ensembl gene id
ENSG00000106927
ucsc gene id
uc004bie.5
refseq accession
NM_001633
hgnc_id
HGNC:453
approved reserved
1986-01-01

Chromosome Location

Chromosome Location

9q32

Gene Summary

Gene Summary

ChineseEnglish

This gene encodes a complex glycoprotein secreted in plasma. The precursor is proteolytically processed into distinct functioning proteins: alpha-1-microglobulin, which belongs to the superfamily of lipocalin transport proteins and may play a role in the regulation of inflammatory processes, and bikunin, which is a urinary trypsin inhibitor belonging to the superfamily of Kunitz-type protease inhibitors and plays an important role in many physiological and pathological processes. This gene is located on chromosome 9 in a cluster of lipocalin genes. [provided by RefSeq, Jul 2008]

OMIM entry for AMBP     Wikipedia entry for AMBP

Gene Sequence

Gene Sequence

Nucleotide sequence of AMBP:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MRSLGALLLL LSACLAVSAG PVPTPPDNIQ VQENFNISRI
41YGKWYNLAIG STCPWLKKIM DRMTVSTLVL GEGATEAEIS
81 MTSTRWRKG VCEETSGAYE KTDTDGKFLY HKSKWNITME
121SYVVHTNYDE YAIFLTKKFS RHHGPTITAK LYGRAPQLRE
161T LLQDFRVV AQGVGIPEDS IFTMADRGEC VPGEQEPEPI
201LIPRVRRAVL PQEEEGSGGG QLVTEVTKKE DSCQLGYSAG
241PC MGMTSRY FYNGTSMACE TFQYGGCMGN GNNFVTEKEC
281LQTCRTVAAC NLPIVRGPCR AFIQLWAFDA VKGKCVLFPY
321GGC QGNGNK FYSEKECREY CGVPGDGDEE LLRFSN
Structure predicted by AlphaFold DB(UniProt: P02760). Color indicates pLDDT confidence (dark blue = high, yellow/orange = low).

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
TCTTAATCCCGAGAGTCCG
58
TGACTTCAGTTACCAGTTGC
58
ATCTTAATCCCGAGAGTCCG
58
GACTTCAGTTACCAGTTGCC
58
CATCTTAATCCCGAGAGTCC
57
ACTTCAGTTACCAGTTGCC
57

Gene Ontology

Subcellular localization of AMBP (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for AMBP:

GO ID
Protein
Source DB
GO:0004867
P02760 (UniProtKB)
TAS
GO:0005515
P02760 (UniProtKB)
IPI
GO:0005515
P02760 (UniProtKB)
IPI
GO:0005576
P02760 (UniProtKB)
NAS
GO:0005576
P02760 (UniProtKB)
NAS
GO:0005576
P02760 (UniProtKB)
TAS
GO:0005576
P02760 (UniProtKB)
TAS
GO:0005576
P02760 (UniProtKB)
TAS
GO:0005615
P02760 (UniProtKB)
IDA
GO:0005886
P02760 (UniProtKB)
IDA
GO:0006898
P02760 (UniProtKB)
TAS
GO:0007155
P02760 (UniProtKB)
NAS
GO:0007565
P02760 (UniProtKB)
NAS
GO:0009986
P02760 (UniProtKB)
IEA
GO:0010951
P02760 (UniProtKB)
IEA
GO:0016032
P02760 (UniProtKB)
IEA
GO:0018298
P02760 (UniProtKB)
IEA
GO:0019855
P02760 (UniProtKB)
NAS
GO:0019862
P02760 (UniProtKB)
IDA
GO:0020037
P02760 (UniProtKB)
IDA
GO:0030163
P02760 (UniProtKB)
IEA
GO:0036094
P02760 (UniProtKB)
IEA
GO:0042167
P02760 (UniProtKB)
NAS
GO:0042803
P02760 (UniProtKB)
IPI
GO:0043231
P02760 (UniProtKB)
IEA
GO:0046329
P02760 (UniProtKB)
TAS
GO:0046904
P02760 (UniProtKB)
NAS
GO:0050777
P02760 (UniProtKB)
NAS
GO:0070062
P02760 (UniProtKB)
IDA
GO:0070062
P02760 (UniProtKB)
IDA
GO:0070062
P02760 (UniProtKB)
IDA
GO:0072562
P02760 (UniProtKB)
IDA
GO:0005576
S4R3Y4 (UniProtKB)
IEA
GO:0036094
S4R3Y4 (UniProtKB)
IEA
GO:0004867
S4R471 (UniProtKB)
IEA
GO:0005576
S4R471 (UniProtKB)
IEA
GO:0010951
S4R471 (UniProtKB)
IEA
GO:0036094
S4R471 (UniProtKB)
IEA

Gene Interactions

Gene Interactions

String
BioGrid
IntAct
mentha
MINT
Reactome
Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Drug-Induced Liver Injury 0.12 1 0 CTD_human
Neoplasm Invasiveness 0.12 1 0 CTD_human
Carcinoma, Transitional Cell 0.12 1 0 CTD_human
Acute kidney injury 0.12 1 0 CTD_human
Nephrolithiasis 0.08 1 0 RGD
Hepatitis E 0.0054487 2 0 LHGDN
Neoplasm Metastasis 0.005167327 9 0 BeFree_LHGDN
Kidney Calculi 0.005005506 2 0 BeFree_GAD
Cardiac Arrest 0.00272435 1 0 LHGDN
Prostatic Neoplasms 0.00272435 1 0 LHGDN

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