APC (APC regulator of WNT signaling pathway)

基因基本信息

基因基本信息

symbol:
APC
locus group:
protein-coding gene
location:
5q22.2
gene_family:
Armadillo repeat containing|Protein phosphatase 1 regulatory subunits
alias symbol:
DP2|DP3|DP2.5|PPP1R46
alias name:
protein phosphatase 1, regulator...
entrez id:
324
ensembl gene id:
ENSG00000134982
ucsc gene id:
uc003kpy.5
refseq accession:
NM_000038
hgnc_id:
HGNC:583
approved reserved:
1986-01-01

基因染色体位置

基因染色体位置

5q22.2

基因简述

基因简述

APC（Adenomatous Polyposis Coli）基因是一个重要的抑癌基因，主要参与调控Wnt信号通路，对细胞增殖、分化和迁移起关键作用。它编码的APC蛋白通过与β-catenin结合，促进其降解，从而抑制Wnt信号通路的过度激活，防止细胞异常增殖。APC蛋白还在细胞骨架调控、染色体稳定性和细胞极性维持中发挥作用。APC基因突变与家族性腺瘤性息肉病（FAP）密切相关，这是一种常染色体显性遗传病，患者肠道内会形成大量息肉，并显著增加结直肠癌风险。此外，APC突变也常见于散发性结直肠癌中。APC基因的失活突变会导致β-catenin积累，持续激活Wnt通路，促进肿瘤发生。APC属于一个保守的基因家族，其家族成员通常参与细胞骨架组织和信号转导。APC基因过表达可能干扰正常Wnt信号传导，影响胚胎发育和组织稳态；而表达降低则可能导致Wnt通路过度激活，促进肿瘤发生。APC还与微管结合蛋白相互作用，影响细胞分裂和迁移。除了癌症，APC突变还与其它疾病如髓母细胞瘤和甲状腺癌有关。该基因的多种剪切变体在不同组织中发挥特定功能，进一步增加了其功能的复杂性。

中文English

这个基因编码充当Wnt信号通路的拮抗剂肿瘤抑制蛋白。它也涉及其他过程，包括细胞迁移和粘附，转录激活，和细胞凋亡。缺陷这个基因导致家族性息肉病（FAP），一种常染色体显性恶性疾病前，通常发展为恶性肿瘤。疾病相关的突变趋向于指定的突变簇区域（MCR）的小区域被聚集并导致截短的蛋白质产物。 [由RefSeq的，2008年7月提供]

OMIM数据库中对APC基因的介绍     Wikipedia数据库中对APC基因的介绍

基因序列

基因序列

APC基因的碱基序列：[NCBI]
Loading Gene Browser...

编码蛋白质

编码蛋白质

蛋白质序列
1MAAASYDQLL KQVEALKMEN SNLRQELEDN SNHLTKLETE
41ASNMKEVLKQ LQGSIEDEAM ASSGQIDLLE RLKELNLDSS
81 NFPGVKLRS KMSLRSYGSR EGSVSSRSGE CSPVPMGSFP
121RRGFVNGSRE STGYLEELEK ERSLLLADLD KEEKEKDWYY
161A QLQNLTKR IDSLPLTENF SLQTDMTRRQ LEYEARQIRV
201AMEEQLGTCQ DMEKRAQRRI ARIQQIEKDI LRIRQLLQSQ
241AT EAERSSQ NKHETGSHDA ERQNEGQGVG EINMATSGNG
281QGSTTRMDHE TASVLSSSST HSAPRRLTSH LGTKVEMVYS
321LLS MLGTHD KDDMSRTLLA MSSSQDSCIS MRQSGCLPLL
361IQLLHGNDKD SVLLGNSRGS KEARARASAA LHNIIHSQPD
401DKRG RREIR VLHLLEQIRA YCETCWEWQE AHEPGMDQDK
441NPMPAPVEHQ ICPAVCVLMK LSFDEEHRHA MNELGGLQAI
481AELLQ VDCE MYGLTNDHYS ITLRRYAGMA LTNLTFGDVA
521NKATLCSMKG CMRALVAQLK SESEDLQQVI ASVLRNLSWR
561ADVNSK KTL REVGSVKALM ECALEVKKES TLKSVLSALW
601NLSAHCTENK ADICAVDGAL AFLVGTLTYR SQTNTLAIIE
641SGGGILR NV SSLIATNEDH RQILRENNCL QTLLQHLKSH
681SLTIVSNACG TLWNLSARNP KDQEALWDMG AVSMLKNLIH
721SKHKMIAM G SAAALRNLMA NRPAKYKDAN IMSPGSSLPS
761LHVRKQKALE AELDAQHLSE TFDNIDNLSP KASHRSKQRH
801KQSLYGDYV FDTNRHDDNR SDNFNTGNMT VLSPYLNTTV
841LPSSSSSRGS LDSSRSEKDR SLERERGIGL GNYHPATENP
881GTSSKRGLQI STTAAQIAK VMEEVSAIHT SQEDRSSGST
921TELHCVTDER NALRRSSAAH THSNTYNFTK SENSNRTCSM
961PYAKLEYKRS S NDSLNSVS SSDGYGKRGQ MKPSIESYSE
1001DDESKFCSYG QYPADLAHKI HSANHMDDND GELDTPINYS
1041LKYSDEQLNS GR QSPSQNE RWARPKHIIE DEIKQSEQRQ
1081SRNQSTTYPV YTESTDDKHL KFQPHFGQQE CVSPYRSRGA
1121NGSETNRVGS NHG INQNVS QSLCQEDDYE DDKPTNYSER
1161YSEEEQHEEE ERPTNYSIKY NEEKRHVDQP IDYSLKYATD
1201IPSSQKQSFS FSKS SSGQS SKTEHMSSSS ENTSTPSSNA
1241KRQNQLHPSS AQSRSGQPQK AATCKVSSIN QETIQTYCVE
1281DTPICFSRCS SLSSL SSAE DEIGCNQTTQ EADSANTLQI
1321AEIKEKIGTR SAEDPVSEVP AVSQHPRTKS SRLQGSSLSS
1361ESARHKAVEF SSGAKS PSK SGAQTPKSPP EHYVQETPLM
1401FSRCTSVSSL DSFESRS
结构预测来自 AlphaFold DB（UniProt: P25054），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

基因突变

基因突变

APC基因的碱基突变：           仅显示部分snp
rs1914       rs12189       rs41115       rs41116       rs42427       rs187075       rs351771       rs351772       rs369952       rs375377       rs376845       rs377860       rs380589       rs383256       rs386522       rs386830       rs390092      

基因表达

基因表达

APC基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
TGTACCACCCTCAGTTCTC
58
CTTCCTTCATATTAGATGCCTCAG
59
ACTCAAATCTTCGACAAGAGC
59
AGTTAAGCTCTTTAAGACGCTC
59
GAATGAACTAGGAATCAACCCT
58
TGTGCTGACAAATTCCATAAGG
59
ATTATTGAAAGTGGAGGTGGGA
60
TCTTAGGATTTGCCTGTGGT
59
TGAAGCAAGGCAAATCAGAG
59
TATTCTTCGCTGTGCTCGT
60
TGAAGCAAGGCAAATCAGAG
59
TATTCTTCGCTGTGCTCGT
60
CAATGAATGAACTAGGTAGGAAGG
59
TCTGCAATGGCCTGTAGTC
60
AAGGCAAATCAGAGTTGCG
59
TGTTCTGAGATGACCTCTGTG
60
CTATGAAAGGCTGCATGAGAG
59
AAACACTCGCAATAACCTGC
60
TGAAGCAAGGCAAATCAGAG
59
TATTCTTCGCTGTGCTCGT
60

转录因子

转录因子

转录因子
影响基因
影响类型
参考文献链接（PubMed）
APC
AKT1
Repression
15888491
APC
AMHR2
Repression
12724325
APC
BIRC5
Unknown
11751382
APC
DLG1
Unknown
21858148
APC
DNMT1
Repression
12538344
APC
F8
Unknown
12010799
APC
KLF4
Unknown
12387883
APC
MYC
Repression
16510874
APC
NOS2
Activation
11935128
APC
ODC1
Repression
12112318

基因本体信息

APC基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

APC基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0000281
A0A087X2F3 (UniProtKB)
IEA
GO:0005634
A0A087X2F3 (UniProtKB)
IEA
GO:0005737
A0A087X2F3 (UniProtKB)
IEA
GO:0006974
A0A087X2F3 (UniProtKB)
IEA
GO:0007026
A0A087X2F3 (UniProtKB)
IEA
GO:0007050
A0A087X2F3 (UniProtKB)
IEA
GO:0008013
A0A087X2F3 (UniProtKB)
IEA
GO:0008285
A0A087X2F3 (UniProtKB)
IEA
GO:0016477
A0A087X2F3 (UniProtKB)
IEA
GO:0030178
A0A087X2F3 (UniProtKB)
IEA
GO:0043065
A0A087X2F3 (UniProtKB)
IEA
GO:0000281
B7Z2B6 (UniProtKB)
IEA
GO:0005634
B7Z2B6 (UniProtKB)
IEA
GO:0005737
B7Z2B6 (UniProtKB)
IEA
GO:0006974
B7Z2B6 (UniProtKB)
IEA
GO:0007026
B7Z2B6 (UniProtKB)
IEA
GO:0007050
B7Z2B6 (UniProtKB)
IEA
GO:0008013
B7Z2B6 (UniProtKB)
IEA
GO:0008285
B7Z2B6 (UniProtKB)
IEA
GO:0016055
B7Z2B6 (UniProtKB)
IEA
GO:0016477
B7Z2B6 (UniProtKB)
IEA
GO:0030178
B7Z2B6 (UniProtKB)
IEA
GO:0043065
B7Z2B6 (UniProtKB)
IEA
GO:0000281
D6RFL6 (UniProtKB)
IEA
GO:0005634
D6RFL6 (UniProtKB)
IEA
GO:0005737
D6RFL6 (UniProtKB)
IEA
GO:0006974
D6RFL6 (UniProtKB)
IEA
GO:0007026
D6RFL6 (UniProtKB)
IEA
GO:0007050
D6RFL6 (UniProtKB)
IEA
GO:0008013
D6RFL6 (UniProtKB)
IEA
GO:0008285
D6RFL6 (UniProtKB)
IEA
GO:0016477
D6RFL6 (UniProtKB)
IEA
GO:0030178
D6RFL6 (UniProtKB)
IEA
GO:0043065
D6RFL6 (UniProtKB)
IEA
GO:0000281
E7EMH9 (UniProtKB)
IEA
GO:0005634
E7EMH9 (UniProtKB)
IEA
GO:0005737
E7EMH9 (UniProtKB)
IEA
GO:0006974
E7EMH9 (UniProtKB)
IEA
GO:0007026
E7EMH9 (UniProtKB)
IEA
GO:0007050
E7EMH9 (UniProtKB)
IEA
GO:0008013
E7EMH9 (UniProtKB)
IEA
GO:0008285
E7EMH9 (UniProtKB)
IEA
GO:0016477
E7EMH9 (UniProtKB)
IEA
GO:0030178
E7EMH9 (UniProtKB)
IEA
GO:0043065
E7EMH9 (UniProtKB)
IEA
GO:0000281
E9PFT7 (UniProtKB)
IEA
GO:0005634
E9PFT7 (UniProtKB)
IEA
GO:0005737
E9PFT7 (UniProtKB)
IEA
GO:0006974
E9PFT7 (UniProtKB)
IEA
GO:0007026
E9PFT7 (UniProtKB)
IEA
GO:0007050
E9PFT7 (UniProtKB)
IEA
GO:0008013
E9PFT7 (UniProtKB)
IEA
GO:0008285
E9PFT7 (UniProtKB)
IEA
GO:0016055
E9PFT7 (UniProtKB)
IEA
GO:0016477
E9PFT7 (UniProtKB)
IEA
GO:0030178
E9PFT7 (UniProtKB)
IEA
GO:0043065
E9PFT7 (UniProtKB)
IEA
GO:0000281
P25054 (UniProtKB)
IMP
GO:0000776
P25054 (UniProtKB)
IDA
GO:0001708
P25054 (UniProtKB)
IBA
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005634
P25054 (UniProtKB)
IDA
GO:0005634
P25054 (UniProtKB)
IDA
GO:0005634
P25054 (UniProtKB)
IDA
GO:0005654
P25054 (UniProtKB)
TAS
GO:0005654
P25054 (UniProtKB)
TAS
GO:0005737
P25054 (UniProtKB)
IDA
GO:0005737
P25054 (UniProtKB)
IDA
GO:0005737
P25054 (UniProtKB)
IDA
GO:0005813
P25054 (UniProtKB)
IDA
GO:0005829
P25054 (UniProtKB)
TAS
GO:0005829
P25054 (UniProtKB)
TAS
GO:0005829
P25054 (UniProtKB)
TAS
GO:0005829
P25054 (UniProtKB)
TAS
GO:0005829
P25054 (UniProtKB)
TAS
GO:0005829
P25054 (UniProtKB)
TAS
GO:0005829
P25054 (UniProtKB)
TAS
GO:0005829
P25054 (UniProtKB)
TAS
GO:0005829
P25054 (UniProtKB)
TAS
GO:0005829
P25054 (UniProtKB)
TAS
GO:0005829
P25054 (UniProtKB)
TAS
GO:0005829
P25054 (UniProtKB)
TAS
GO:0005829
P25054 (UniProtKB)
TAS
GO:0005829
P25054 (UniProtKB)
TAS
GO:0005829
P25054 (UniProtKB)
TAS
GO:0005829
P25054 (UniProtKB)
TAS
GO:0005829
P25054 (UniProtKB)
TAS
GO:0005829
P25054 (UniProtKB)
TAS
GO:0005829
P25054 (UniProtKB)
TAS
GO:0005829
P25054 (UniProtKB)
TAS
GO:0005829
P25054 (UniProtKB)
TAS
GO:0005829
P25054 (UniProtKB)
TAS
GO:0005829
P25054 (UniProtKB)
TAS
GO:0005829
P25054 (UniProtKB)
TAS
GO:0005886
P25054 (UniProtKB)
IDA
GO:0005923
P25054 (UniProtKB)
IDA
GO:0005938
P25054 (UniProtKB)
IEA
GO:0006461
P25054 (UniProtKB)
IDA
GO:0006921
P25054 (UniProtKB)
TAS
GO:0006974
P25054 (UniProtKB)
IDA
GO:0007026
P25054 (UniProtKB)
IDA
GO:0007026
P25054 (UniProtKB)
IMP
GO:0007050
P25054 (UniProtKB)
IDA
GO:0007094
P25054 (UniProtKB)
IMP
GO:0007155
P25054 (UniProtKB)
NAS
GO:0007163
P25054 (UniProtKB)
IEA
GO:0007389
P25054 (UniProtKB)
IBA
GO:0008013
P25054 (UniProtKB)
IPI
GO:0008013
P25054 (UniProtKB)
IPI
GO:0008013
P25054 (UniProtKB)
IPI
GO:0008013
P25054 (UniProtKB)
IPI
GO:0008017
P25054 (UniProtKB)
IDA
GO:0008017
P25054 (UniProtKB)
IDA
GO:0008285
P25054 (UniProtKB)
IDA
GO:0016055
P25054 (UniProtKB)
TAS
GO:0016328
P25054 (UniProtKB)
IDA
GO:0016342
P25054 (UniProtKB)
IDA
GO:0016477
P25054 (UniProtKB)
IMP
GO:0019887
P25054 (UniProtKB)
IDA
GO:0019901
P25054 (UniProtKB)
IPI
GO:0030027
P25054 (UniProtKB)
IDA
GO:0030335
P25054 (UniProtKB)
IMP
GO:0030425
P25054 (UniProtKB)
IEA
GO:0030877
P25054 (UniProtKB)
IDA
GO:0030877
P25054 (UniProtKB)
IDA
GO:0030877
P25054 (UniProtKB)
IDA
GO:0030877
P25054 (UniProtKB)
IDA
GO:0031016
P25054 (UniProtKB)
IEA
GO:0031175
P25054 (UniProtKB)
IEA
GO:0031274
P25054 (UniProtKB)
IMP
GO:0031965
P25054 (UniProtKB)
IEA
GO:0032587
P25054 (UniProtKB)
IDA
GO:0032886
P25054 (UniProtKB)
IMP
GO:0042493
P25054 (UniProtKB)
IEA
GO:0043025
P25054 (UniProtKB)
IEA
GO:0043065
P25054 (UniProtKB)
IMP
GO:0043161
P25054 (UniProtKB)
TAS
GO:0044295
P25054 (UniProtKB)
IEA
GO:0044306
P25054 (UniProtKB)
IEA
GO:0045202
P25054 (UniProtKB)
IEA
GO:0045295
P25054 (UniProtKB)
IPI
GO:0045595
P25054 (UniProtKB)
IBA
GO:0045732
P25054 (UniProtKB)
IGI
GO:0045732
P25054 (UniProtKB)
IGI
GO:0045732
P25054 (UniProtKB)
IC
GO:0045736
P25054 (UniProtKB)
IDA
GO:0051010
P25054 (UniProtKB)
IDA
GO:0051988
P25054 (UniProtKB)
NAS
GO:0051988
P25054 (UniProtKB)
IMP
GO:0060070
P25054 (UniProtKB)
NAS
GO:0060070
P25054 (UniProtKB)
IC
GO:0070830
P25054 (UniProtKB)
NAS
GO:0070852
P25054 (UniProtKB)
IEA
GO:0090090
P25054 (UniProtKB)
IGI
GO:0090090
P25054 (UniProtKB)
IGI
GO:0097305
P25054 (UniProtKB)
IEA
GO:1904885
P25054 (UniProtKB)
TAS
GO:1904886
P25054 (UniProtKB)
TAS
GO:1990090
P25054 (UniProtKB)
IEA
GO:1990909
P25054 (UniProtKB)
NAS
GO:2000211
P25054 (UniProtKB)
IEA
GO:0045296
P25054 (UniProtKB)
IDA
GO:0005881
P25054 (UniProtKB)
IBA
GO:0005886
P25054 (UniProtKB)
IDA
GO:0005913
P25054 (UniProtKB)
IDA
GO:0000281
R4GMU6 (UniProtKB)
IEA
GO:0005634
R4GMU6 (UniProtKB)
IEA
GO:0005737
R4GMU6 (UniProtKB)
IEA
GO:0006974
R4GMU6 (UniProtKB)
IEA
GO:0007026
R4GMU6 (UniProtKB)
IEA
GO:0007050
R4GMU6 (UniProtKB)
IEA
GO:0008013
R4GMU6 (UniProtKB)
IEA
GO:0008285
R4GMU6 (UniProtKB)
IEA
GO:0016477
R4GMU6 (UniProtKB)
IEA
GO:0030178
R4GMU6 (UniProtKB)
IEA
GO:0043065
R4GMU6 (UniProtKB)
IEA

基因相关microRNA

基因相关microRNA

可能调控 APC基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

String
BioGrid
IntAct
mentha
MINT
Reactome
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关联基因 作用方式 资源库来源/分值

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Adenomatous Polyposis Coli 0.776808767 654 12 BeFree_CLINVAR_CTD_human_GAD_LHGDN_MGD_ORPHANET_UNIPROT
Desmoid disease, hereditary 0.361085767 4 0 BeFree_CLINVAR_CTD_human_ORPHANET
Liver carcinoma 0.328067311 21 1 BeFree_CLINVAR_CTD_human_GAD_MGD
Gardner Syndrome 0.244810009 9 10 BeFree_CLINVAR_GAD_ORPHANET
Medulloblastoma 0.24434307 18 0 BeFree_CTD_human_UNIPROT
Stomach Neoplasms 0.240814326 3 2 BeFree_CLINVAR_CTD_human
Colorectal Neoplasms 0.240791019 114 2 BeFree_CTD_human_GAD_LHGDN
Colorectal Cancer 0.24 321 5 BeFree_GAD_MGD
Colonic Neoplasms 0.231776019 46 1 BeFree_CTD_human_GAD_LHGDN_RGD
Adenoma 0.190731622 149 4 BeFree_CTD_human_GAD_LHGDN

基因相关文献

基因相关文献

Delayed Argon Plasma Coagulation After Endoscopic Injection Sclerotherapy for Esophageal Varices Reduces Recurrence Risk.
Yanagita T, Hikichi T, Nakamura J, Kato T, Hashimoto M, Otsuka M, Kameoka E, Suzuki R, Sugimoto M, Asama H, Shimizu H, Osawa K, Ohira R, Kudo K, Nemoto D, Kobayakawa M, Ohira H DEN Open IF: 1.5 2027-04-00
Lymph node-targeted mRNA delivery of fine-tuned peptide-nanocomplexes for SARS-CoV-2 Vaccination.
Jeong H, Yoon G, Lee DW, Yu H, Kim YB, Kim N, Choi J, Shin E, Kim YJ, Jeong HS, Kim HG, Kim D, Nah WS, Lee JY, Chung CP, Park YJ Biomaterials IF: 13.6 2027-01-00
Somatic Mosaic AXIN2-associated Colonic Polyposis Predominantly Involving the Proximal Colon: A Case Report.
Murakami T, Arai M, Eguchi H, Hirasawa Y, Hata W, Otsuki Y, Yamauchi T, Kamba E, Yao T, Nagahara A DEN Open IF: 1.5 2027-04-00
Temporal trends in breast cancer incidence and mortality in Australia: An Age-Period-Cohort analysis.
Nguyen PD, Page AN, McBride KA, Spittal MJ, Munasinghe S Cancer Epidemiol IF: 3.0 2026-04-00
Dynamic estimation of metabolic state during CAR T cell production.
Jagannathan NS, Sin WX, Teo DBL, Kairi F, Luah YH, Lim FLWI, Seng MS, Soh SY, Lee YH, Tucker-Kellogg L, Birnbaum ME, Ram RJ Cell Rep Methods IF: 5.8 2026-02-23
Source identification and health risks of heavy metals in Huixian Karst wetland sediments: a multi-model approach.
Dong K, Yang J, Li H, Lam SM, Sin JC, Xu Y, Wang D Environ Geochem Health IF: 4.3 2026-02-12
Enterocyte Autoantibodies (GECAs) and HLA: Their Relationship with HIV Infection Pathogenesis.
Arnaiz-Villena A, Lledo T, Vaquero-Yuste C, Juarez I, Martin-Villa JM Int J Mol Sci IF: 3.226 2026-01-27
Ex Vivo Expansion of Melanoma Tumor-Infiltrating Lymphocytes Leads to a Dominant Exhausted T-cell Population with a Lack of Memory Markers.
Coppola G, Kerr S, Cha PC, Bersenev A, Olino K, Kluger HM, Sznol M, Weiss SA, Bosenberg MW, Kleinstein SH, Krause DS, Hurwitz ME, Katz SG Cancer Immunol Res IF: 7.9 2026-05-04

基因相关服务

基因相关服务

基因相关评论

基因相关评论

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