ATP4A (ATPase H+/K+ transporting subunit alpha)

Gene Basic Information

Gene Basic Information

symbol
ATP4A
locus group
protein-coding gene
location
19q13.12
gene_family
P-type ATPases
alias symbol
ATP6A
alias name
gastric H,K-ATPase alpha subunit|H…
entrez id
495
ensembl gene id
ENSG00000105675
ucsc gene id
uc002oal.2
refseq accession
NM_000704
hgnc_id
HGNC:819
approved reserved
1990-09-10

Chromosome Location

Chromosome Location

19q13.12

Gene Summary

Gene Summary

ChineseEnglish

The protein encoded by this gene belongs to a family of P-type cation-transporting ATPases. The gastric H+, K+-ATPase is a heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but heavily glycosylated beta subunit. This enzyme is a proton pump that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for gastric acid secretion. This gene encodes a catalytic alpha subunit of the gastric H+, K+-ATPase. [provided by RefSeq, Jul 2008]

OMIM entry for ATP4A     Wikipedia entry for ATP4A

Gene Sequence

Gene Sequence

Nucleotide sequence of ATP4A:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MGKAENYELY SVELGPGPGG DMAAKMSKKK KAGGGGGKRK
41EKLENMKKEM EINDHQLSVA ELEQKYQTSA TKGLSASLAA
81 ELLLRDGPN ALRPPRGTPE YVKFARQLAG GLQCLMWVAA
121AICLIAFAIQ ASEGDLTTDD NLYLAIALIA VVVVTGCFGY
161Y QEFKSTNI IASFKNLVPQ QATVIRDGDK FQINADQLVV
201GDLVEMKGGD RVPADIRILA AQGCKVDNSS LTGESEPQTR
241SP ECTHESP LETRNIAFFS TMCLEGTVQG LVVNTGDRTI
281IGRIASLASG VENEKTPIAI EIEHFVDIIA GLAILFGATF
321FIV AMCIGY TFLRAMVFFM AIVVAYVPEG LLATVTVCLS
361LTAKRLASKN CVVKNLEAVE TLGSTSVICS DKTGTLTQNR
401MTVS HLWFD NHIHTADTTE DQSGQTFDQS SETWRALCRV
441LTLCNRAAFK SGQDAVPVPK RIVIGDASET ALLKFSELTL
481GNAMG YRDR FPKVCEIPFN STNKFQLSIH TLEDPRDPRH
521LLVMKGAPER VLERCSSILI KGQELPLDEQ WREAFQTAYL
561SLGGLG ERV LGFCQLYLNE KDYPPGYAFD VEAMNFPSSG
601LCFAGLVSMI DPPRATVPDA VLKCRTAGIR VIMVTGDHPI
641TAKAIAA SV GIISEGSETV EDIAARLRVP VDQVNRKDAR
681ACVINGMQLK DMDPSELVEA LRTHPEMVFA RTSPQQKLVI
721VESCQRLG A IVAVTGDGVN DSPALKKADI GVAMGIAGSD
761AAKNAADMIL LDDNFASIVT GVEQGRLIFD NLKKSIAYTL
801TKNIPELTP YLIYITVSVP LPLGCITILF IELCTDIFPS
841VSLAYEKAES DIMHLRPRNP KRDRLVNEPL AAYSYFQIGA
881IQSFAGFTDY FTAMAQEGW FPLLCVGLRA QWEDHHLQDL
921QDSYGQEWTF GQRLYQQYTC YTVFFISIEV CQIADVLIRK
961TRRLSAFQQG F FRNKILVI AIVFQVCIGC FLCYCPGMPN
1001IFNFMPIRFQ WWLVPLPYGI LIFVYDEIRK LGVRCCPGSW
1041WDQELYY
Structure predicted by AlphaFold DB(UniProt: P20648). Color indicates pLDDT confidence (dark blue = high, yellow/orange = low).

Gene Variants

Gene Variants

SNP variants of ATP4A:           Showing partial SNPs
rs743541       rs748212       rs748213       rs748214       rs909067       rs909068       rs1047217       rs2230181       rs2251124       rs2251125       rs2251250       rs2301617       rs2733737       rs2733738       rs2733739       rs2733740       rs2733743      

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
GGTTAATCGCAAGGATGCC
59
GTTGTCGAAGATCAGTCGAC
59
CGACGACAATCTGTACCTG
58
TTGAATTCCTGGTAGTAGCCA
59
CTTGTATCCATGATTGACCCAC
59
GTTACCATGATCACCCGGA
59
TTCATCAGCATTGAGGTGTG
59
GATCTTATTCCTGAAGAAGCCT
58
CGACGACAATCTGTACCTG
58
TTGAATTCCTGGTAGTAGCCA
59
CGTAGACCAGGTTAATCGC
58
TCGAAGATCAGTCGACCAG
59
ACGACAATCTGTACCTGGC
60
TCTTGAATTCCTGGTAGTAGCC
60
GTGTGATCAATGGCATGCA
59
TCGAAGATCAGTCGACCAG
59
CATCAGCATTGAGGTGTGC
60
GGATCTTATTCCTGAAGAAGCC
59
GTTAATCGCAAGGATGCCC
59
GGTTGTCGAAGATCAGTCGA
60

Gene Ontology

Subcellular localization of ATP4A (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for ATP4A:

GO ID
Protein
Source DB
GO:0000166
M0R249 (UniProtKB)
IEA
GO:0000287
P20648 (UniProtKB)
IEA
GO:0005391
P20648 (UniProtKB)
IBA
GO:0005524
P20648 (UniProtKB)
IEA
GO:0005615
P20648 (UniProtKB)
IDA
GO:0005886
P20648 (UniProtKB)
TAS
GO:0005887
P20648 (UniProtKB)
TAS
GO:0006810
P20648 (UniProtKB)
TAS
GO:0006883
P20648 (UniProtKB)
IBA
GO:0008900
P20648 (UniProtKB)
IEA
GO:0010107
P20648 (UniProtKB)
IBA
GO:0010248
P20648 (UniProtKB)
IEA
GO:0015991
P20648 (UniProtKB)
IBA
GO:0030007
P20648 (UniProtKB)
IBA
GO:0034220
P20648 (UniProtKB)
TAS
GO:0036376
P20648 (UniProtKB)
IBA
GO:0043231
P20648 (UniProtKB)
IBA

Gene Interactions

Gene Interactions

String
BioGrid
mentha
Reactome
Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Helicobacter pylori infection 0.005700279 21 0 BeFree
Gastroesophageal reflux disease 0.005700279 21 0 BeFree
Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site 0.005157396 19 0 BeFree
Eosinophilic disorder 0.001628651 6 0 BeFree
Disorder characterized by eosinophilia 0.001628651 6 0 BeFree
Eosinophilia 0.001628651 6 0 BeFree
Stomach Carcinoma 0.001085767 4 0 BeFree
Malignant neoplasm of stomach 0.001085767 4 0 BeFree
Osteopetrosis 0.001085767 4 0 BeFree
Eosinophilic esophagitis 0.000814326 3 0 BeFree

Related Publications

Related Publications

Taurine suppresses gastric intestinal metaplasia in patient-derived organoids and Atp4a -/- mice.
Liu K, Zhang X, Li FZ, Zheng PY, Mi Y World J Gastrointest Oncol IF: 2.7 2026-02-15
Expansion of the world health organization (WHO) gastric neuroendocrine tumor classification: introducing types 4 and 5.
Strosberg J, Chatterjee D, Lauwers GY, Haider M, Halfdanarson TR J Natl Cancer Inst IF: 7.7 2026-09-12
Genetic causal association between kidney stones and proton pump inhibitors.
Jiang Y, Lin L, Cheng C, Zhou L Int Urol Nephrol IF: 2.2 2026-09-00
Proton Pump Inhibitors Inhibit Pancreatic Secretion: Role of Gastric and Non-Gastric H+/K+-ATPases.
Wang Jing, Barbuskaite Dagne, Tozzi Marco, Giannuzzo Andrea, Sørensen Christiane E, Novak Ivana PLoS One IF: 2.6 2016-04-18
ATP4a is required for development and function of the Xenopus mucociliary epidermis - a potential model to study proton pump inhibitor-associated pneumonia.
Walentek Peter, Beyer Tina, Hagenlocher Cathrin, Müller Christina, Feistel Kerstin, Schweickert Axel, Harland Richard M, Blum Martin Dev Biol IF: 2.1 2016-06-10

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