ATP4B (ATPase H+/K+ transporting subunit beta)

Gene Basic Information

Gene Basic Information

symbol
ATP4B
locus group
protein-coding gene
location
13q34
gene_family
P-type ATPases
alias symbol
ATP6B
alias name
None
entrez id
496
ensembl gene id
ENSG00000186009
ucsc gene id
uc001vtz.5
refseq accession
NM_000705
hgnc_id
HGNC:820
approved reserved
1992-11-26

Chromosome Location

Chromosome Location

13q34

Gene Summary

Gene Summary

ChineseEnglish

The protein encoded by this gene belongs to a family of P-type cation-transporting ATPases. The gastric H+, K+-ATPase is a heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but heavily glycosylated beta subunit. This enzyme is a proton pump that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for gastric acid secretion. This gene encodes the beta subunit of the gastric H+, K+-ATPase. [provided by RefSeq, Jul 2008]

OMIM entry for ATP4B     Wikipedia entry for ATP4B

Gene Sequence

Gene Sequence

Nucleotide sequence of ATP4B:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MAALQEKKTC GQRMEEFQRY CWNPDTGQML GRTLSRWVWI
41SLYYVAFYVV MTGLFALCLY VLMQTVDPYT PDYQDQLRSP
81 GVTLRPDVY GEKGLEIVYN VSDNRTWADL TQTLHAFLAG
121YSPAAQEDSI NCTSEQYFFQ ESFRAPNHTK FSCKFTADML
161Q NCSGLADP NFGFEEGKPC FIIKMNRIVK FLPSNGSAPR
201VDCAFLDQPR ELGQPLQVKY YPPNGTFSLH YFPYYGKKAQ
241PH YSNPLVA AKLLNIPRNA EVAIVCKVMA EHVTFNNPHD
281PYEGKVEFKL KIEK
Structure predicted by AlphaFold DB(UniProt: P51164). Color indicates pLDDT confidence (dark blue = high, yellow/orange = low).

Gene Variants

Gene Variants

SNP variants of ATP4B:           Showing partial SNPs
rs4074271       rs4076410       rs6577060       rs9285616       rs9324254       rs9324255       rs9669827       rs9669831       rs9669863       rs9669886       rs9670223       rs9670289       rs9670304       rs9670310       rs9670412       rs9670626       rs9670733      

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
CCTTCCTAGCAGGCTACTC
59
AAACTCTCCTGGAAGAAGTACTG
59
CTTCCTAGCAGGCTACTCTC
59
AAACTCTCCTGGAAGAAGTACTG
59
CCTTCCTAGCAGGCTACTC
59
AACTCTCCTGGAAGAAGTACTG
59

Gene Ontology

Subcellular localization of ATP4B (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for ATP4B:

GO ID
Protein
Source DB
GO:0005515
P51164 (UniProtKB)
IPI
GO:0005886
P51164 (UniProtKB)
TAS
GO:0005890
P51164 (UniProtKB)
IEA
GO:0006813
P51164 (UniProtKB)
IEA
GO:0006814
P51164 (UniProtKB)
IEA
GO:0007155
P51164 (UniProtKB)
IEA
GO:0008900
P51164 (UniProtKB)
TAS
GO:0010243
P51164 (UniProtKB)
IEA
GO:0032496
P51164 (UniProtKB)
IEA
GO:0034220
P51164 (UniProtKB)
TAS
GO:1902600
P51164 (UniProtKB)
IEA

Gene Interactions

Gene Interactions

String
BioGrid
IntAct
mentha
Reactome
Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Cardiovascular Diseases 0.002367032 1 0 GAD
Stomach Carcinoma 0.000542884 2 0 BeFree
Malignant neoplasm of stomach 0.000542884 2 0 BeFree
Coronary Arteriosclerosis 0.000271442 1 0 BeFree
Coronary heart disease 0.000271442 1 0 BeFree
Coronary Artery Disease 0.000271442 1 0 BeFree

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