CALCR (calcitonin receptor)

基因基本信息

基因基本信息

symbol:
CALCR
locus group:
protein-coding gene
location:
7q21.3
gene_family:
Calcitonin receptors
alias symbol:
CTR|CT-R
alias name:
None
entrez id:
799
ensembl gene id:
ENSG00000004948
ucsc gene id:
uc003umw.3
refseq accession:
NM_001742
hgnc_id:
HGNC:1440
approved reserved:
1993-03-23

基因染色体位置

基因染色体位置

7q21.3

基因简述

基因简述

CALCR（降钙素受体，Calcitonin Receptor）是一种G蛋白偶联受体（GPCR），属于B类GPCR家族，主要通过与降钙素（Calcitonin）或相关肽类（如降钙素基因相关肽CGRP）结合来激活下游信号通路。该受体在骨骼、肾脏和中枢神经系统中高表达，其核心功能是调节钙磷代谢、抑制破骨细胞活性（减少骨吸收）和促进肾脏排钙，从而维持血钙平衡。CALCR的突变可能导致功能异常，如家族性高钙尿症（Familial Hypocalciuric Hypercalcemia）或骨质疏松，因其影响钙稳态调控。过表达CALCR可能增强降钙素的抗骨吸收作用，但可能引发低钙血症；而表达降低则与骨质疏松或高钙血症相关，因破骨细胞活性失控。CALCR属于降钙素受体家族（包括CALCRL等），该家族成员均通过结合肽类激素调控代谢和神经信号。此外，CALCR与CGRP受体的交叉作用使其在偏头痛（CGRP通路过度激活）和炎症性疼痛中具有潜在治疗靶点价值。专业术语解释：G蛋白偶联受体（GPCR）是一类跨膜蛋白，通过G蛋白传递细胞外信号；破骨细胞是分解骨组织的细胞；降钙素基因相关肽（CGRP）是一种血管舒张神经肽。若中文术语不准确，可参考英文原词（如Calcitonin Receptor）。

中文English

该基因编码的肽激素降钙素的高亲和性受体，属于七个跨膜G蛋白偶联受体亚家族。所编码的蛋白质是参与维持钙稳态以及在调节破骨细胞介导的??骨吸收。在这种基因多态性已与骨密度和骨质疏松症的发病的变化相关联。选择性剪接结果在多个抄本变形。 [由RefSeq的，2009年09月提供]

OMIM数据库中对CALCR基因的介绍     Wikipedia数据库中对CALCR基因的介绍

基因序列

基因序列

CALCR基因的碱基序列：[NCBI]
Loading Gene Browser...

编码蛋白质

编码蛋白质

蛋白质序列
1MRFTFTSRCL ALFLLLNHPT PILPAFSNQT YPTIEPKPFL
41YVVGRKKMMD AQYKCYDRMQ QLPAYQGEGP YCNRTWDGWL
81 CWDDTPAGV LSYQFCPDYF PDFDPSEKVT KYCDEKGVWF
121KHPENNRTWS NYTMCNAFTP EKLKNAYVLY YLAIVGHSLS
161I FTLVISLG IFVFFRSLGC QRVTLHKNMF LTYILNSMII
201IIHLVEVVPN GELVRRDPVS CKILHFFHQY MMACNYFWML
241CE GIYLHTL IVVAVFTEKQ RLRWYYLLGW GFPLVPTTIH
281AITRAVYFND NCWLSVETHL LYIIHGPVMA ALVVNFFFLL
321NIV RVLVTK MRETHEAESH MYLKAVKATM ILVPLLGIQF
361VVFPWRPSNK MLGKIYDYVM HSLIHFQGFF VATIYCFCNN
401EVQT TVKRQ WAQFKIQWNQ RWGRRPSNRS ARAAAAAAEA
441GDIPIYICHQ EPRNEPANNQ GEESAEIIPL NIIEQESSA
结构预测来自 AlphaFold DB（UniProt: P30988），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

基因突变

基因突变

CALCR基因的碱基突变：           仅显示部分snp
rs17080       rs713137       rs721315       rs721381       rs724683       rs757033       rs757034       rs961261       rs972945       rs972946       rs972978       rs989506       rs999277       rs1000912       rs1003885       rs1024431       rs1042138      

基因表达

基因表达

CALCR基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
ATAGGAAGGCATTGAGCCT
59
TACTACTTCAACCAGGTGGA
58
CAAGGAGAAGGTCCATATTGC
59
ATAGGACAATACTCCAGCCG
59
ATAGGAAGGCATTGAGCCT
59
TACTACTTCAACCAGGTGGA
58
CAAGGAGAAGGTCCATATTGC
59
ATAGGACAATACTCCAGCCG
59
CAAGGAGAAGGTCCATATTGC
59
ATAGGACAATACTCCAGCCG
59
CAAGGAGAAGGTCCATATTGC
58
ATAGGACAATACTCCAGCCG
59
CAAGGAGAAGGTCCATATTGC
59
ATAGGACAATACTCCAGCCG
59
ATAGGAAGGCATTGAGCCT
59
TACTACTTCAACCAGGTGGA
58
TATAGGAAGGCATTGAGCCT
58
ACTACTTCAACCAGGTGGA
58
AGAAGATGATGGATGCACAG
57
TGCAATATGGACCTTCTCCT
58

转录因子

转录因子

      尚未收录相关数据

基因本体信息

CALCR基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

CALCR基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0001669
A0A0A0MRG0 (UniProtKB)
IEA
GO:0004948
A0A0A0MRG0 (UniProtKB)
IEA
GO:0005929
A0A0A0MRG0 (UniProtKB)
IEA
GO:0007166
A0A0A0MRG0 (UniProtKB)
IEA
GO:0007189
A0A0A0MRG0 (UniProtKB)
IEA
GO:0007204
A0A0A0MRG0 (UniProtKB)
IEA
GO:0016021
A0A0A0MRG0 (UniProtKB)
IEA
GO:0030279
A0A0A0MRG0 (UniProtKB)
IEA
GO:0030316
A0A0A0MRG0 (UniProtKB)
IEA
GO:0043488
A0A0A0MRG0 (UniProtKB)
IEA
GO:0004948
A0A0A0MSQ7 (UniProtKB)
IEA
GO:0007166
A0A0A0MSQ7 (UniProtKB)
IEA
GO:0007186
A0A0A0MSQ7 (UniProtKB)
IEA
GO:0016021
A0A0A0MSQ7 (UniProtKB)
IEA
GO:0004948
A0A0C4DG16 (UniProtKB)
IEA
GO:0007166
A0A0C4DG16 (UniProtKB)
IEA
GO:0007186
A0A0C4DG16 (UniProtKB)
IEA
GO:0016021
A0A0C4DG16 (UniProtKB)
IEA
GO:0004948
D8MIV0 (UniProtKB)
IEA
GO:0007186
D8MIV0 (UniProtKB)
IEA
GO:0016020
D8MIV0 (UniProtKB)
IEA
GO:0004872
P30988 (UniProtKB)
IDA
GO:0004872
P30988 (UniProtKB)
IDA
GO:0004948
P30988 (UniProtKB)
IEA
GO:0004948
P30988 (UniProtKB)
IDA
GO:0004948
P30988 (UniProtKB)
IDA
GO:0005515
P30988 (UniProtKB)
IPI
GO:0005515
P30988 (UniProtKB)
IPI
GO:0005623
P30988 (UniProtKB)
IEA
GO:0005886
P30988 (UniProtKB)
TAS
GO:0005886
P30988 (UniProtKB)
TAS
GO:0005886
P30988 (UniProtKB)
TAS
GO:0005886
P30988 (UniProtKB)
TAS
GO:0005886
P30988 (UniProtKB)
TAS
GO:0005887
P30988 (UniProtKB)
NAS
GO:0005887
P30988 (UniProtKB)
NAS
GO:0007166
P30988 (UniProtKB)
IEA
GO:0007186
P30988 (UniProtKB)
IEA
GO:0007186
P30988 (UniProtKB)
IEA
GO:0007189
P30988 (UniProtKB)
NAS
GO:0007189
P30988 (UniProtKB)
IDA
GO:0007204
P30988 (UniProtKB)
IDA
GO:0008565
P30988 (UniProtKB)
IDA
GO:0015031
P30988 (UniProtKB)
IDA
GO:0030819
P30988 (UniProtKB)
IDA
GO:0031623
P30988 (UniProtKB)
IDA
GO:0032841
P30988 (UniProtKB)
IPI
GO:0032841
P30988 (UniProtKB)
IPI
GO:0032841
P30988 (UniProtKB)
IPI
GO:0032841
P30988 (UniProtKB)
IDA
GO:0032841
P30988 (UniProtKB)
IDA
GO:0032841
P30988 (UniProtKB)
IDA
GO:0032841
P30988 (UniProtKB)
IPI
GO:0045762
P30988 (UniProtKB)
IDA
GO:0045762
P30988 (UniProtKB)
IDA
GO:0045762
P30988 (UniProtKB)
IDA
GO:0045762
P30988 (UniProtKB)
IDA
GO:0045762
P30988 (UniProtKB)
IDA
GO:0051384
P30988 (UniProtKB)
IDA
GO:0072659
P30988 (UniProtKB)
IDA
GO:0007190
P30988 (UniProtKB)
IDA
GO:0007202
P30988 (UniProtKB)
IDA
GO:0032841
P30988 (UniProtKB)
IDA

基因相关microRNA

基因相关microRNA

可能调控 CALCR基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

String
BioGrid
IntAct
mentha
MINT
Reactome
加载中…
关联基因 作用方式 资源库来源/分值

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Osteoporosis 0.126991475 8 0 BeFree_CTD_human_GAD_LHGDN
Hypercalcemia 0.120271442 2 0 BeFree_CTD_human
Osteoporosis, Postmenopausal 0.004734064 2 0 GAD
Osteopenia 0.004734064 2 0 GAD
Malignant neoplasm of breast 0.004538567 9 0 BeFree_GAD
Multiple Myeloma 0.002995792 1 0 BeFree_LHGDN
Urinary Calculi 0.00272435 1 0 LHGDN
Malignant neoplasm of lung 0.002638474 2 0 BeFree_GAD
Malignant neoplasm of urinary bladder 0.002638474 2 0 BeFree_GAD
Juvenile arthritis 0.002638474 1 0 BeFree_GAD

基因相关文献

基因相关文献

Association between candidate genes and FRAX scores in postmenopausal women.
Pepe J, Viviani A, Cipriani C, Ciminelli BM, Jodice C, Colangelo L, Forti M, Santori R, Terreri S, Minisola S, Latini S, Occhiuto M, Malaspina P, Novelletto A Endocrine IF: 3.3 2026-08-08
Aging Exacerbates Binge Ethanol-Mediated Bone Toxicity in Mice.
Pedersen KB, Bordelon M, Baker E, Luo M, Taylor CM, Chen JR, Ronis MJ Alcohol Clin Exp Res (Hoboken) 2026-08-00
Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U-87 MG cells.
Gupta P, Furness SG, Gharbi T, De Paoli-Iseppi R, Joshi SS, Clark M, Hare DL, Wookey P FEBS Open Bio IF: 2.7 2026-08-13
Condylar Bone Quality in Growing Children Is Associated With Genetic Polymorphisms in Genes Involved in Calcium and Phosphate Maintenance.
Küchler EC, Reis CLB, Fonseca-Souza G, Hemming D, Baratto-Filho F, de Araujo CM, Beisel-Memmert S, Feltrin-Souza J, Meger MN, Cavalcante-Leão BL Biomed Res Int IF: 2.9 None
Identifying quiescent satellite cells: a scoping review of transcriptomic markers and limitations.
Syroid AL, Steele AP, Murach KA, Hawke TJ Am J Physiol Cell Physiol IF: 5.4 2026-06-01
The calcitonin receptor controls osteophyte formation, but not cartilage degeneration and subchondral bone loss in experimental osteoarthritis.
Jiang S, Xie W, Ballhause TM, Sevecke J, Augustin R, Rolvien T, Maleitzke T, Baranowsky A, Keller J Bone Joint Res IF: 5.5 2026-02-20

基因相关服务

基因相关服务

基因相关评论

基因相关评论

评论加载中...

登录后即可发表评论 登录 注册

联系地址

山东省济南市章丘区文博路2号

齐鲁师范学院 genelibs生信实验室

山东省济南市高新区舜华路750号

大学科技园北区F座4单元2楼

电话： 0531-88819269

微信公众号

关注微信订阅号，实时查看信息，关注医学生物学动态。


商务邮箱

E-mail: [email protected]

版权所有 © 2025.Genelibs 济南弘晖生物技术有限公司 鲁ICP备20007159号-2