CCT6B (chaperonin containing TCP1 subunit 6B)
- symbol:
- CCT6B
- locus group:
- protein-coding gene
- location:
- 17q12
- gene_family:
- Chaperonins
- alias symbol:
- Cctz2|TSA303
- alias name:
- None
- entrez id:
- 10693
- ensembl gene id:
- ENSG00000132141
- ucsc gene id:
- uc002hig.4
- refseq accession:
- NM_006584
- hgnc_id:
- HGNC:1621
- approved reserved:
- 1999-02-26
CCT6B（Chaperonin Containing TCP1 Subunit 6B）是分子伴侣蛋白家族CCT/TRiC（TCP1环状复合物）的一个亚基，属于CCT基因家族。该家族由8个亚基（CCT1-8）组成，共同形成双环复合物结构，主要功能是协助细胞内蛋白质的正确折叠，尤其对细胞骨架蛋白（如肌动蛋白、微管蛋白）和细胞周期调控蛋白的折叠至关重要。CCT6B在复合物中与其他亚基协同作用，利用ATP水解提供的能量帮助新生肽链形成正确三维结构。其表达产物具有高度保守的ATP结合域和底物识别区域，作用位点集中在细胞质内。突变可能导致CCT6B功能异常，引发蛋白质错误折叠和聚集，这与神经退行性疾病（如阿尔茨海默病、帕金森病）和某些癌症（如乳腺癌、肝癌）的发生相关。当CCT6B过表达时，可能增强蛋白质折叠效率但可能干扰正常细胞周期；而表达降低则会导致错误折叠蛋白积累，激活未折叠蛋白反应（UPR），诱发细胞凋亡。CCT基因家族的共性包括：均由16-18个亚基组成双环结构、依赖ATPase活性、参与应激响应和细胞分化调控。最新研究发现CCT6B在精子发生和免疫调节中也有重要作用，其单核苷酸多态性（SNP）可能影响个体对特定疾病的易感性。专业术语解释：分子伴侣（chaperone）指协助蛋白质折叠的辅助蛋白；ATPase指能水解ATP释放能量的酶；未折叠蛋白反应（UPR）是细胞应对错误折叠蛋白的应激机制。该基因曾被称为CCT-zeta或CCT6-2，目前国际统一命名为CCT6B。
This gene encodes a molecular chaperone that is a member of the chaperonin-containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Gene Ontology
Subcellular localization of CCT6B (and its protein):
- plasma membrane
- cytoplasm
- extracellular
- golgi
- vesicle
- cytoskeleton
- endoplasmic reticulum
- nucleus
- endosome
- lysosome
- mitochondrion
Gene Ontology (GO) terms for CCT6B:
| Interacting Gene | Interaction | Source/Score |
| Disease | Score | NofPmids | NofSnps | Source |
| Burkitt Lymphoma | 0.12 | 1 | 0 | CTD_human |
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: [email protected]
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
