CD74基因详情-基因数据库-基因云馆

CD74 (CD74 molecule)

symbol:: CD74
locus group:: protein-coding gene
location:: 5q33.1
gene_family:: CD molecules
alias symbol:: CLIP
alias name:: HLA-DR-gamma|Ia-associated invar...
entrez id:: 972
ensembl gene id:: ENSG00000019582
ucsc gene id:: uc003lse.4
refseq accession:: NM_004355
hgnc_id:: HGNC:1697
approved reserved:: 1986-01-01

5q33.1

CD74是一种重要的免疫相关基因，编码的蛋白质是主要组织相容性复合体II类分子（MHC-II）的恒定链（invariant chain，Ii）。它的主要功能是帮助MHC-II分子正确折叠并转运至内体（endosome），在那里与外来抗原肽结合，最终呈递给CD4+ T细胞以启动适应性免疫应答。CD74还在细胞信号传导中发挥作用，可作为巨噬细胞迁移抑制因子（MIF）的受体，参与炎症反应和细胞存活调控。CD74主要表达于抗原呈递细胞（如B细胞、树突状细胞和巨噬细胞），但在某些上皮细胞和肿瘤细胞中也有表达。CD74基因突变可能导致MHC-II分子组装或转运缺陷，引发免疫缺陷疾病如裸淋巴细胞综合征（bare lymphocyte syndrome）。CD74过表达常见于多种癌症（如淋巴瘤、乳腺癌和前列腺癌），与肿瘤进展、转移和不良预后相关，可能通过激活NF-κB等促生存信号通路。CD74表达降低则可能损害抗原呈递功能，导致免疫应答减弱。CD74属于MHC-II相关基因家族，该家族成员多参与抗原处理和呈递过程。CD74的剪切变体（如p41）还具有调节蛋白酶活性的功能，能影响内体中的抗原降解。在自身免疫疾病中，CD74-MIF相互作用可能促进炎症反应，成为治疗靶点。此外，CD74与病毒感染（如EB病毒）的免疫逃逸机制也有关联。

中文English

该基??因联营公司与Ⅱ类主要组织相容性复合体（MHC）编码的蛋白质，是一种调节抗原提呈的免疫反应的重要伴侣。它也可作为细胞因子巨噬细胞迁移抑制因子（MIF），当结合到编码蛋白质，启动存活途径和细胞增殖细胞表面受体。这种蛋白也与淀粉样前体蛋白（APP）相互作用，并抑制生产淀粉样蛋白β（Abeta的）的。编码不同亚型多重选择性剪接转录变异体已经确定。 [由RefSeq的，2011年8月提供]

OMIM数据库中对CD74基因的介绍 Wikipedia数据库中对CD74基因的介绍

CD74基因的碱基序列：[NCBI]

Loading Gene Browser...

蛋白质序列

1MHRRRSRSCR EDQKPVMDDQ RDLISNNEQL PMLGRRPGAP
41ESKCSRGALY TGFSILVTLL LAGQATTAYF LYQQQGRLDK
81
LTVTSQNLQ LENLRMKLPK PPKPVSKMRM ATPLLMQALP
121MGALPQGPMQ NATKYGNMTE DHVMHLLQNA DPLKVYPPLK
161G
SFPENLRH LKNTMETIDW KVFESWMHHW LLFEMSRHSL
201EQKPTDAPPK VLTKCQEEVS HIPAVHPGSF RPKCDENGNY
241LP
LQCYGSI GYCWCVFPNG TEVPNTRSRG HHNCSESLEL
281EDPSSGLGVT KQDLGPVPM

结构预测来自 AlphaFold DB（UniProt: P04233），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

CD74基因的碱基突变：仅显示部分snp

rs1004978 rs1051661 rs1056400 rs1065086 rs1065303 rs1065357 rs1529696 rs1560661 rs2071368 rs2288817 rs2748247 rs2748248 rs2748249 rs3194843 rs3211023 rs3776828 rs3797618

CD74基因在不同组织中的表达： [UniProt]

正向引物序列

正向Tm值

反向引物序列

反向Tm值

评分

ATCTCCAACAATGAGCAACTG

GTACAGGAAGTAGGCGGTG

TAGACTGGAAGGTCTTTGAGAG

CCTGTACCTTTCGGTGGAG

ATCTCCAACAATGAGCAACTG

GTACAGGAAGTAGGCGGTG

AGAGGACCATGTGATGCAC

CAGCTCTCAAAGACCTTCCA

TCTCCAACAATGAGCAACTG

TACTTGGTGGCATTCTGCA

CTTACCCTCGTTCCTGTCC

ATACTTGGTGGCATTCTGC

TCTTTGAGAGCTGGATGCA

TCCAGTGACTCTTTCGGTG

CTTTGAGAGCTGGATGCAC

CTTGGTCAGTACTTTCGGTG

CTTTGAGAGCTGGATGCAC

CTTGGTCAGTACTTTCGGTG

AGAGGACCATGTGATGCAC

CAGCTCTCAAAGACCTTCCA

转录因子

影响基因

影响类型

参考文献链接（PubMed）

NFKB1

CD74

Unknown

8164652

RELA

CD74

Unknown

8164652

CD74基因（以及对应的蛋白质）的细胞分布位置：

[UniProt] [GenomeNet]

质膜
细胞质
细胞外
高尔基体
囊泡
细胞骨架
内质网
细胞核
内体
溶酶体
线粒体

CD74基因的本体（GO）信息：

GO库代码

对应的蛋白质

来源代码

GO:0005622

E7EQJ3 (UniProtKB)

IEA

GO:0006886

E7EQJ3 (UniProtKB)

IEA

GO:0006955

E7EQJ3 (UniProtKB)

IEA

GO:0016021

E7EQJ3 (UniProtKB)

IEA

GO:0019882

E7EQJ3 (UniProtKB)

IEA

GO:0042289

E7EQJ3 (UniProtKB)

IEA

GO:0005622

E7ESL3 (UniProtKB)

IEA

GO:0006886

E7ESL3 (UniProtKB)

IEA

GO:0006955

E7ESL3 (UniProtKB)

IEA

GO:0016021

E7ESL3 (UniProtKB)

IEA

GO:0019882

E7ESL3 (UniProtKB)

IEA

GO:0042289

E7ESL3 (UniProtKB)

IEA

GO:0005622

H0YBZ2 (UniProtKB)

IEA

GO:0006886

H0YBZ2 (UniProtKB)

IEA

GO:0006955

H0YBZ2 (UniProtKB)

IEA

GO:0016021

H0YBZ2 (UniProtKB)

IEA

GO:0019882

H0YBZ2 (UniProtKB)

IEA

GO:0042289

H0YBZ2 (UniProtKB)

IEA

GO:0005622

H0YBZ8 (UniProtKB)

IEA

GO:0006886

H0YBZ8 (UniProtKB)

IEA

GO:0006955

H0YBZ8 (UniProtKB)

IEA

GO:0016021

H0YBZ8 (UniProtKB)

IEA

GO:0019882

H0YBZ8 (UniProtKB)

IEA

GO:0042289

H0YBZ8 (UniProtKB)

IEA

GO:0000139

P04233 (UniProtKB)

TAS

GO:0000139

P04233 (UniProtKB)

TAS

GO:0000187

P04233 (UniProtKB)

IEA

GO:0001516

P04233 (UniProtKB)

IDA

GO:0001540

P04233 (UniProtKB)

IPI

GO:0001961

P04233 (UniProtKB)

IMP

GO:0002606

P04233 (UniProtKB)

IEA

GO:0002792

P04233 (UniProtKB)

IDA

GO:0002830

P04233 (UniProtKB)

IEA

GO:0002906

P04233 (UniProtKB)

IEA

GO:0004896

P04233 (UniProtKB)

IDA

GO:0005515

P04233 (UniProtKB)

IPI

GO:0005622

P04233 (UniProtKB)

TAS

GO:0005765

P04233 (UniProtKB)

TAS

GO:0005765

P04233 (UniProtKB)

TAS

GO:0005765

P04233 (UniProtKB)

TAS

GO:0005765

P04233 (UniProtKB)

TAS

GO:0005765

P04233 (UniProtKB)

TAS

GO:0005765

P04233 (UniProtKB)

TAS

GO:0005771

P04233 (UniProtKB)

IEA

GO:0005773

P04233 (UniProtKB)

IDA

GO:0005886

P04233 (UniProtKB)

TAS

GO:0005886

P04233 (UniProtKB)

TAS

GO:0005886

P04233 (UniProtKB)

TAS

GO:0005886

P04233 (UniProtKB)

TAS

GO:0006461

P04233 (UniProtKB)

ISS

GO:0006886

P04233 (UniProtKB)

ISS

GO:0006952

P04233 (UniProtKB)

IEA

GO:0007165

P04233 (UniProtKB)

IDA

GO:0008283

P04233 (UniProtKB)

IDA

GO:0009897

P04233 (UniProtKB)

IEA

GO:0009986

P04233 (UniProtKB)

IDA

GO:0012507

P04233 (UniProtKB)

TAS

GO:0012507

P04233 (UniProtKB)

TAS

GO:0016020

P04233 (UniProtKB)

IDA

GO:0016021

P04233 (UniProtKB)

IDA

GO:0016064

P04233 (UniProtKB)

ISS

GO:0019883

P04233 (UniProtKB)

NAS

GO:0019886

P04233 (UniProtKB)

TAS

GO:0019955

P04233 (UniProtKB)

IPI

GO:0019955

P04233 (UniProtKB)

IPI

GO:0023026

P04233 (UniProtKB)

IDA

GO:0030658

P04233 (UniProtKB)

TAS

GO:0030658

P04233 (UniProtKB)

TAS

GO:0030666

P04233 (UniProtKB)

TAS

GO:0030666

P04233 (UniProtKB)

TAS

GO:0030669

P04233 (UniProtKB)

TAS

GO:0030669

P04233 (UniProtKB)

TAS

GO:0030890

P04233 (UniProtKB)

IMP

GO:0032588

P04233 (UniProtKB)

TAS

GO:0032588

P04233 (UniProtKB)

TAS

GO:0032588

P04233 (UniProtKB)

TAS

GO:0032588

P04233 (UniProtKB)

TAS

GO:0032588

P04233 (UniProtKB)

TAS

GO:0035691

P04233 (UniProtKB)

IEA

GO:0035692

P04233 (UniProtKB)

IDA

GO:0035693

P04233 (UniProtKB)

IEA

GO:0035718

P04233 (UniProtKB)

IPI

GO:0042289

P04233 (UniProtKB)

ISS

GO:0042289

P04233 (UniProtKB)

NAS

GO:0042658

P04233 (UniProtKB)

IDA

GO:0042802

P04233 (UniProtKB)

TAS

GO:0043030

P04233 (UniProtKB)

NAS

GO:0043066

P04233 (UniProtKB)

IDA

GO:0043202

P04233 (UniProtKB)

TAS

GO:0043518

P04233 (UniProtKB)

IDA

GO:0044183

P04233 (UniProtKB)

IDA

GO:0045058

P04233 (UniProtKB)

NAS

GO:0045059

P04233 (UniProtKB)

IEA

GO:0045060

P04233 (UniProtKB)

IEA

GO:0045581

P04233 (UniProtKB)

IEA

GO:0045582

P04233 (UniProtKB)

IEA

GO:0048146

P04233 (UniProtKB)

IMP

GO:0050731

P04233 (UniProtKB)

IDA

GO:0050900

P04233 (UniProtKB)

TAS

GO:0050998

P04233 (UniProtKB)

IEA

GO:0051085

P04233 (UniProtKB)

IEA

GO:0060907

P04233 (UniProtKB)

ISS

GO:0070062

P04233 (UniProtKB)

IDA

GO:0070062

P04233 (UniProtKB)

IDA

GO:0070374

P04233 (UniProtKB)

IMP

GO:0070374

P04233 (UniProtKB)

IDA

GO:0071556

P04233 (UniProtKB)

TAS

GO:0071556

P04233 (UniProtKB)

TAS

GO:0071556

P04233 (UniProtKB)

TAS

GO:0090023

P04233 (UniProtKB)

ISS

GO:1902166

P04233 (UniProtKB)

IMP

GO:2000343

P04233 (UniProtKB)

ISS

GO:0042613

P04233 (UniProtKB)

ISS

可能调控 CD74基因的相关microRNA：

String

BioGrid

IntAct

mentha

MINT

Reactome

加载中…

关联基因	作用方式	资源库来源/分值

KEGG
Reactomepathway

名称
4612 Antigen processing and presentation [PATH:hsa04612]
5152 Tuberculosis [PATH:hsa05152]
5168 Herpes simplex infection [PATH:hsa05168]

名称
Adaptive Immune System
Immune System
MHC class II antigen presentation

疾病名称

关系值

NofPmids

NofSnps

来源

疾病名称	关系值	NofPmids	NofSnps	来源
Non-Small Cell Lung Carcinoma	0.121085767	5	0	BeFree_CTD_human
Mammary Neoplasms	0.120542884	3	0	BeFree_CTD_human
Liver Failure, Acute	0.12	1	0	CTD_human
Diabetic Nephropathy	0.003267234	3	0	BeFree_LHGDN
Lung Neoplasms	0.002995792	2	0	BeFree_LHGDN
Multiple Myeloma	0.002995792	1	0	BeFree_LHGDN
Liver carcinoma	0.00272435	1	0	LHGDN
Prostatic Neoplasms	0.00272435	1	0	LHGDN
Kidney Neoplasm	0.00272435	1	0	LHGDN
Celiac Disease	0.002367032	1	0	GAD

Enhanced MIF/CD74 axis activity shapes B cell functioning following traumatic spinal cord injury.

Rubio S, Beckers L, Coenen H, van Laake-Geelen CCM, Depreitere B, Bamps S, Cornips EMJ, Buelens E, Peuskens D, Deckers J, Somers V, Fraussen J J Neuroinflammation IF: 5.102 2026-04-22

Single-Cell Sequencing and Mendelian Randomization Reveal T Cell Nuclear Factor Genes in Hepatocellular Carcinoma Progression.

Chen Y, Yang X, Zhong L, Chen K, Luo L Hum Mutat IF: 1.8 None

Integrating bulk, single-cell, and spatial transcriptomics to identify a novel pyroptosis-related gene signature for predicting prognosis and tumor immune landscape in triple-negative breast cancer.

Xiang L, Rao J, Ma A, Zhang Y, Li C, Xie T, Xue H, Chen Z, Liu T, Yuan J, Yan H Front Immunol IF: 7.0 None

Identification of Molecular Subtypes and Prognostic Characteristics in Sepsis Based on T-Helper 17 Cell Differentiation-Related Genes.

Li X, Tan L, Ding Y, Zhang B Shock IF: 2.7 2026-03-01

Organized immunity in the CNS: what stroke reveals about neuroinflammation and lymphoid niches.

Lee-Chang C J Clin Invest IF: 14.3 2026-03-02

Ectopic B lymphocyte follicles exacerbate ischemic brain damage via MIF-CD74/CXCR4 and interferon signaling.

Yang S, Zhang H, Xu LL, Zhou LQ, Chu YH, Chen L, Pang XW, Zhang LY, Zhu LF, Dong MH, Shang K, Xiao J, Wu LJ, Wang W, Tian DS, Qin C J Clin Invest IF: 14.3 2026-03-02

Integrated Omics Approach to Delineate the Mechanisms of Doxorubicin-Induced Cardiotoxicity.

Dabour MS, Abdelgawad IY, Sadaf B, Daniel MR, Grant MKO, Blaes AH, Jacobson PA, Zordoky BN Pharmaceuticals (Basel) 2026-01-29

CCR1+ monocytes facilitating bronchopulmonary dysplasia through regulation of S100A8 and MMP8.

Geng Y, Chen Q, Wang M, Wang S, Ji Y, Ji X, Lu M, Wang A, Zhu H, Hu J Front Immunol IF: 7.0 None

PLCG1 promotes sevoflurane-induced neuronal ferroptosis by enhancing K63-linked ubiquitination and proteasomal degradation of LAMP2A.

Chen J, Cai Y, Wang J, Yue K, Sun Y Exp Brain Res IF: 2.1 2026-02-27

Opioid-induced transcriptional reprogramming of cerebrospinal fluid immune cells drives neuroinflammation in SIV-infected rhesus macaques.

Acharya A, Ambikan AT, Neogi U, Lamberty BG, Callen S, Buch S, Fox HS, Byrareddy SN Res Sq 2026-02-05

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CD74 (CD74 molecule)

基因基本信息

基因基本信息

基因染色体位置

基因染色体位置

基因简述

基因简述

基因序列

基因序列

编码蛋白质

编码蛋白质

基因突变

基因突变

基因表达

基因表达

基因引物

基因引物

转录因子

转录因子

基因本体信息

基因相关microRNA

基因相关microRNA

基因相互作用关系

基因相互作用关系

基因通路

基因通路

基因相关疾病

基因相关疾病

基因相关文献

基因相关文献

基因相关服务

基因相关服务

基因相关评论

基因相关评论

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