CPPED1 (calcineurin like phosphoesterase domain containing 1)

Gene Basic Information

Gene Basic Information

symbol
CPPED1
locus group
protein-coding gene
location
16p13.12
gene_family
-
alias symbol
CSTP1|FLJ11151
alias name
complete S transactivated protein 1
entrez id
55313
ensembl gene id
ENSG00000103381
ucsc gene id
uc002dca.5
refseq accession
NM_018340
hgnc_id
HGNC:25632
approved reserved
2009-03-13

Chromosome Location

Chromosome Location

16p13.12

Gene Summary

Gene Summary

CPPED1（Calcitonin Pseudogene 1）属于钙调素相关基因家族，主要作为假基因存在，不编码功能性蛋白。该基因家族成员通常与钙离子信号通路相关，参与细胞增殖、分化及凋亡等过程。CPPED1虽为假基因，但可能通过调控其他功能基因的表达或作为竞争性内源RNA（ceRNA）影响细胞功能。研究表明，CPPED1的突变或表达异常可能与某些癌症（如乳腺癌、前列腺癌）的发生发展相关，但其具体机制尚不明确。过表达CPPED1可能干扰钙调素信号通路，影响细胞周期调控，导致增殖异常；而降低表达则可能减弱其对相关通路的调控作用，间接影响其他基因的功能。该基因家族的共性在于参与钙依赖性信号传导，调控多种生理过程。目前关于CPPED1的研究较少，其生物学功能及临床意义仍需进一步探索。

OMIM entry for CPPED1     Wikipedia entry for CPPED1

Gene Sequence

Gene Sequence

Nucleotide sequence of CPPED1:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MSAAEAGGVF HRARGRTLAA FPAEKESEWK GPFYFILGAD
41PQFGLIKAWS TGDCDNGGDE WEQEIRLTEQ AVQAINKLNP
81 KPKFFVLCG DLIHAMPGKP WRTEQTEDLK RVLRAVDRAI
121PLVLVSGNHD IGNTPTAETV EEFCRTWGDD YFSFWVGGVL
161F LVLNSQFY ENPSKCPSLK QAQDQWLDEQ LSIARQRHCQ
201HAIVFQHIPL FLESIDEDDD YYFNLSKSTR KKLADKFIHA
241GV KVVFSGH YHRNAGGTYQ NLDMVVSSAI GCQLGRDPHG
281LRVVVVTAEK IVHRYYSLDE LSEKGIEDDL MDLIKKK
Structure predicted by AlphaFold DB(UniProt: Q9BRF8). Color indicates pLDDT confidence (dark blue = high, yellow/orange = low).

Gene Variants

Gene Variants

SNP variants of CPPED1:           Showing partial SNPs
rs9351       rs748242       rs748682       rs748683       rs755214       rs755215       rs869860       rs882908       rs882909       rs938895       rs938896       rs938897       rs938898       rs938899       rs938900       rs938901       rs938902      

Gene Expression

Gene Expression

Tissue expression of CPPED1:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
AATTCTTCGTTCTGTGCGG
59
TCATCTAGACTGTAGTATCGGTG
59
CTAAGTGAAGGCCAGAAACTC
59
CCTTTCCATTCGCTTTCCT
58
CATGCCAGGTGTCAAAGTC
59
ATGACACCACCATGTCGAG
60
AACCTCAGCAAGTCCACTC
60
GAACACGACTTTGACACCTG
60
CCATCAACAAGCTGAACCC
59
GAACACGACTTTGACACCTG
60
AATTCTTCGTTCTGTGCGG
59
TCATCTAGACTGTAGTATCGGT
58
AACCTCAGCAAGTCCACTC
60
AACACGACTTTGACACCTG
58
TAAGTGAAGGCCAGAAACTC
58
CCTTTCCATTCGCTTTCCT
58
AATTCTTCGTTCTGTGCGG
59
CATCTAGACTGTAGTATCGGTG
57
CCATCAACAAGCTGAACCC
59
AACACGACTTTGACACCTG
58

Gene Ontology

Subcellular localization of CPPED1 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for CPPED1:

GO ID
Protein
Source DB
GO:0004721
Q9BRF8 (UniProtKB)
IEA
GO:0005737
Q9BRF8 (UniProtKB)
IDA
GO:0005886
Q9BRF8 (UniProtKB)
IDA
GO:0006470
Q9BRF8 (UniProtKB)
IEA
GO:0046872
Q9BRF8 (UniProtKB)
IEA
GO:0070062
Q9BRF8 (UniProtKB)
IDA

Related microRNA

Related microRNA

microRNAs potentially regulating CPPED1:     

Gene Interactions

Gene Interactions

String
BioGrid
mentha
Loading…
Interacting Gene Interaction Source/Score

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Tobacco Use Disorder 0.002367032 1 0 GAD
melanoma 0.000271442 1 0 BeFree
Malignant neoplasm of urinary bladder 0.000271442 1 0 BeFree
Carcinoma of bladder 0.000271442 1 0 BeFree
Nevus 0.000271442 1 0 BeFree
Melanocytic nevus 0.000271442 1 0 BeFree
Benign melanocytic nevus 0.000271442 1 0 BeFree
Melanocytic nevus of skin 0.000271442 1 0 BeFree

Related Publications

Related Publications

A multilevel genomic approach to uncover causal connections between CPFE and lung cancer subtypes: A two-sample Mendelian randomization study.
Yang C, Chen P, Chai X, Yang Q, Wu S, Zhao H, Wang Z, Bao Y Medicine (Baltimore) IF: 2.0 2025-08-22
Deciphering the Cellular Targets of Bioactive Compounds Using a Chloroalkane Capture Tag.
Ohana Rachel Friedman, Kirkland Thomas A, Woodroofe Carolyn C, Levin Sergiy, Uyeda H Tetsuo, Otto Paul, Hurst Robin, Robers Matthew B, Zimmerman Kris, Encell Lance P, Wood Keith V ACS Chem Biol IF: 3.6 2016-05-13
Identification of putative SNPs in progressive retinal atrophy affected Canis lupus familiaris using exome sequencing.
Reddy Bhaskar, Kelawala Divyesh N, Shah Tejas, Patel Anand B, Patil Deepak B, Parikh Pinesh V, Patel Namrata, Parmar Nidhi, Mohapatra Amit B, Singh Krishna M, Menon Ramesh, Pandya Dipal, Jakhesara Subhash J, Koringa Prakash G, Rao Mandava V, Joshi Chaitanya G Mamm Genome IF: 2.6 2016-09-12
New candidate loci identified by array-CGH in a cohort of 100 children presenting with syndromic obesity.
Vuillaume Marie-Laure, Naudion Sophie, Banneau Guillaume, Diene Gwenaelle, Cartault Audrey, Cailley Dorothée, Bouron Julie, Toutain Jérôme, Bourrouillou Georges, Vigouroux Adeline, Bouneau Laurence, Nacka Fabienne, Kieffer Isabelle, Arveiler Benoit, Knoll-Gellida Anja, Babin Patrick J, Bieth Eric, Jouret Béatrice, Julia Sophie, Sarda Pierre, Geneviève David, Faivre Laurence, Lacombe Didier, Barat Pascal, Tauber Maithé, Delrue Marie-Ange, Rooryck Caroline Am J Med Genet A IF: 1.7 2015-03-31
Two novel type 2 diabetes loci revealed through integration of TCF7L2 DNA occupancy and SNP association data.
Johnson Matthew E, Zhao Jianhua, Schug Jonathan, Deliard Sandra, Xia Qianghua, Guy Vanessa C, Sainz Jesus, Kaestner Klaus H, Wells Andrew D, Grant Struan F A BMJ Open Diabetes Res Care 2014-12-03
Downregulation of CPPED1 expression improves glucose metabolism in vitro in adipocytes.
Vaittinen Maija, Kaminska Dorota, Käkelä Pirjo, Eskelinen Matti, Kolehmainen Marjukka, Pihlajamäki Jussi, Uusitupa Matti, Pulkkinen Leena Diabetes IF: 9.3 2013-12-26

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