CST1 (cystatin SN)

Gene Basic Information

Gene Basic Information

symbol
CST1
locus group
protein-coding gene
location
20p11.21
gene_family
-
alias symbol
-
alias name
None
entrez id
1469
ensembl gene id
ENSG00000170373
ucsc gene id
uc061vvz.1
refseq accession
NM_001898
hgnc_id
HGNC:2473
approved reserved
1990-02-06

Chromosome Location

Chromosome Location

20p11.21

Gene Summary

Gene Summary

ChineseEnglish

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a cysteine proteinase inhibitor found in saliva, tears, urine, and seminal fluid. [provided by RefSeq, Jul 2008]

OMIM entry for CST1     Wikipedia entry for CST1

Gene Sequence

Gene Sequence

Nucleotide sequence of CST1:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MAQYLSTLLL LLATLAVALA WSPKEEDRII PGGIYNADLN
41DEWVQRALHF AISEYNKATK DDYYRRPLRV LRARQQTVGG
81 VNYFFDVEV GRTICTKSQP NLDTCAFHEQ PELQKKQLCS
121FEIYEVPWEN RRSLVKSRCQ ES
Structure predicted by AlphaFold DB(UniProt: P01037). Color indicates pLDDT confidence (dark blue = high, yellow/orange = low).

Gene Variants

Gene Variants

SNP variants of CST1:           Showing partial SNPs
rs2982       rs1048314       rs2070855       rs2070856       rs3188296       rs3188297       rs3188301       rs3188303       rs3188305       rs3188307       rs3188313       rs3188314       rs3188319       rs3188320       rs3188322       rs3892306       rs4260306      

Gene Expression

Gene Expression

Tissue expression of CST1:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
ACCATATGTACCAAGTCCCA
58
GCACAACTGTTTCTTCTGC
58
ACCATATGTACCAAGTCCCA
58
GCACAACTGTTTCTTCTGC
58
TATGTACCAAGTCCCAGCC
59
AAGAGCACAACTGTTTCTTCTG
60
TATGTACCAAGTCCCAGCC
59
AAGAGCACAACTGTTTCTTCTG
60
ATATGTACCAAGTCCCAGCC
59
AGAGCACAACTGTTTCTTCTG
59
ATATGTACCAAGTCCCAGCC
59
AGAGCACAACTGTTTCTTCTG
59

Gene Ontology

Subcellular localization of CST1 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for CST1:

GO ID
Protein
Source DB
GO:0001580
P01037 (UniProtKB)
IDA
GO:0004869
P01037 (UniProtKB)
IEA
GO:0005515
P01037 (UniProtKB)
IPI
GO:0005615
P01037 (UniProtKB)
IDA
GO:0005615
P01037 (UniProtKB)
IDA
GO:0005615
P01037 (UniProtKB)
IDA
GO:0010951
P01037 (UniProtKB)
IEA

Related microRNA

Related microRNA

microRNAs potentially regulating CST1:     

Gene Interactions

Gene Interactions

String
BioGrid
IntAct
mentha
Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Hay fever 0.120271442 1 0 BeFree_CTD_human
Stomach Neoplasms 0.12 1 0 CTD_human
Prostatic Neoplasms 0.12 1 0 CTD_human
Diabetes Mellitus, Non-Insulin-Dependent 0.002367032 1 0 GAD
Stomach Carcinoma 0.000542884 2 0 BeFree
Neoplasm Metastasis 0.000542884 2 0 BeFree
Colorectal Carcinoma 0.000542884 2 0 BeFree
Malignant neoplasm of stomach 0.000542884 2 0 BeFree
Carcinogenesis 0.000542884 2 0 BeFree
Non-Small Cell Lung Carcinoma 0.000271442 1 0 BeFree

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