CST2 (cystatin SA)

Gene Basic Information

Gene Basic Information

symbol
CST2
locus group
protein-coding gene
location
20p11.21
gene_family
-
alias symbol
-
alias name
cystatin 2
entrez id
1470
ensembl gene id
ENSG00000170369
ucsc gene id
uc002wtq.2
refseq accession
NM_001322
hgnc_id
HGNC:2474
approved reserved
1990-02-06

Chromosome Location

Chromosome Location

20p11.21

Gene Summary

Gene Summary

ChineseEnglish

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a secreted thiol protease inhibitor found at high levels in saliva, tears and seminal plasma. [provided by RefSeq, Jul 2008]

OMIM entry for CST2     Wikipedia entry for CST2

Gene Sequence

Gene Sequence

Nucleotide sequence of CST2:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MAWPLCTLLL LLATQAVALA WSPQEEDRII EGGIYDADLN
41DERVQRALHF VISEYNKATE DEYYRRLLRV LRAREQIVGG
81 VNYFFDIEV GRTICTKSQP NLDTCAFHEQ PELQKKQLCS
121FQIYEVPWED RMSLVNSRCQ EA
Structure predicted by AlphaFold DB(UniProt: P09228). Color indicates pLDDT confidence (dark blue = high, yellow/orange = low).

Gene Variants

Gene Variants

SNP variants of CST2:           Showing partial SNPs
rs4239738       rs4365536       rs4378872       rs4407312       rs4432530       rs4504066       rs4527282       rs6036548       rs6049156       rs6049157       rs6049158       rs6049159       rs6106729       rs6106730       rs6106731       rs6106732       rs6114318      

Gene Expression

Gene Expression

Tissue expression of CST2:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
ACCATATGTACCAAGTCCCA
58
GCACAACTGTTTCTTCTGC
58
TATGTACCAAGTCCCAGCC
59
AAGAGCACAACTGTTTCTTCTG
60
ATATGTACCAAGTCCCAGCC
59
AGAGCACAACTGTTTCTTCTG
59

Gene Ontology

Subcellular localization of CST2 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for CST2:

GO ID
Protein
Source DB
GO:0001580
P09228 (UniProtKB)
IDA
GO:0004869
P09228 (UniProtKB)
IEA
GO:0005515
P09228 (UniProtKB)
IPI
GO:0005515
P09228 (UniProtKB)
IPI
GO:0005515
P09228 (UniProtKB)
IPI
GO:0005615
P09228 (UniProtKB)
IDA
GO:0005615
P09228 (UniProtKB)
IDA
GO:0005615
P09228 (UniProtKB)
IDA
GO:0010951
P09228 (UniProtKB)
IEA

Related microRNA

Related microRNA

microRNAs potentially regulating CST2:     

Gene Interactions

Gene Interactions

String
BioGrid
IntAct
mentha
Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Rheumatoid Arthritis 0.002367032 1 1 GAD
Cerebrovascular accident 0.002367032 1 0 GAD
Intracranial Hemorrhages 0.002367032 1 0 GAD
Cerebral Hemorrhage 0.002367032 1 0 GAD
Subarachnoid Hemorrhage 0.002367032 1 0 GAD
Hereditary cystatin C amyloid angiopathy 0.001085767 4 0 BeFree
Enteritis 0.000542884 2 0 BeFree
Plaque, Amyloid 0.000542884 2 0 BeFree
Amyloidosis 0.000271442 1 0 BeFree
Malignant neoplasm of ovary 0.000271442 1 0 BeFree

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