CST5 (cystatin D)

Gene Basic Information

Gene Basic Information

symbol
CST5
locus group
protein-coding gene
location
20p11.21
gene_family
-
alias symbol
-
alias name
None
entrez id
1473
ensembl gene id
ENSG00000170367
ucsc gene id
uc002wtr.2
refseq accession
NM_001900
hgnc_id
HGNC:2477
approved reserved
1993-01-20

Chromosome Location

Chromosome Location

20p11.21

Gene Summary

Gene Summary

ChineseEnglish

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a protein found in saliva and tears. The encoded protein may play a protective role against proteinases present in the oral cavity. [provided by RefSeq, Jul 2008]

OMIM entry for CST5     Wikipedia entry for CST5

Gene Sequence

Gene Sequence

Nucleotide sequence of CST5:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MMWPMHTPLL LLTALMVAVA GSASAQSRTL AGGIHATDLN
41DKSVQCALDF AISEYNKVIN KDEYYSRPLQ VMAAYQQIVG
81 GVNYYFNVK FGRTTCTKSQ PNLDNCPFND QPKLKEEEFC
121SFQINEVPWE DKISILNYKC RKV
Structure predicted by AlphaFold DB(UniProt: P28325). Color indicates pLDDT confidence (dark blue = high, yellow/orange = low).

Gene Variants

Gene Variants

SNP variants of CST5:           Showing partial SNPs
rs1799841       rs2071442       rs2071443       rs2071444       rs2071445       rs2285059       rs4075883       rs4239742       rs4239743       rs4239744       rs4295079       rs4350819       rs4813509       rs4813510       rs4815243       rs4815244       rs6049201      

Gene Expression

Gene Expression

Tissue expression of CST5:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
ACTGAAAGAGGAAGAGTTCTG
57
GCACTTGTAGTTCAGAATGGA
58
TGAAAGAGGAAGAGTTCTGCT
59
GGCACTTGTAGTTCAGAATGG
59
CTGAAAGAGGAAGAGTTCTGC
59
GCACTTGTAGTTCAGAATGGA
58

Transcription Factors

Transcription Factors

Transcription Factors
Target Gene
Interaction Type
PubMed References
VDR
CST5
Activation
19662683

Gene Ontology

Subcellular localization of CST5 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for CST5:

GO ID
Protein
Source DB
GO:0004869
P28325 (UniProtKB)
IDA
GO:0005515
P28325 (UniProtKB)
IPI
GO:0005515
P28325 (UniProtKB)
IPI
GO:0005515
P28325 (UniProtKB)
IPI
GO:0005515
P28325 (UniProtKB)
IPI
GO:0005576
P28325 (UniProtKB)
IDA
GO:0010951
P28325 (UniProtKB)
IEA
GO:0070062
P28325 (UniProtKB)
IDA
GO:0070062
P28325 (UniProtKB)
IDA

Related microRNA

Related microRNA

microRNAs potentially regulating CST5:     

Gene Interactions

Gene Interactions

String
BioGrid
mentha
Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Tobacco Use Disorder 0.002367032 1 0 GAD
Hereditary cystatin C amyloid angiopathy 0.001085767 4 0 BeFree
Malignant tumor of colon 0.000542884 2 0 BeFree
Plaque, Amyloid 0.000542884 2 0 BeFree
Colon Carcinoma 0.000542884 2 0 BeFree
Non-Malignant Ascites Adverse Event 0.000271442 1 0 BeFree
Alzheimer's Disease 0.000271442 1 0 BeFree
Medullary carcinoma of thyroid 0.000271442 1 0 BeFree
Ovarian Carcinoma 0.000271442 1 0 BeFree
Amyloidosis 0.000271442 1 0 BeFree

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