CTSB (cathepsin B)

基因基本信息

基因基本信息

symbol:
CTSB
locus group:
protein-coding gene
location:
8p23.1
gene_family:
Cathepsins
alias symbol:
None
alias name:
None
entrez id:
1508
ensembl gene id:
ENSG00000164733
ucsc gene id:
uc003wuq.4
refseq accession:
NM_147780
hgnc_id:
HGNC:2527
approved reserved:
2001-06-22

基因染色体位置

基因染色体位置

8p23.1

基因简述

基因简述

CTSB（组织蛋白酶B）是一种溶酶体半胱氨酸蛋白酶，属于木瓜蛋白酶家族（C1A亚家族），在细胞内蛋白质降解和代谢中发挥重要作用。CTSB的主要功能是参与溶酶体途径的蛋白质水解，能够降解细胞外基质成分如胶原蛋白和层粘连蛋白，在组织重塑、免疫反应和细胞凋亡等生理过程中起关键作用。CTSB的活性位点包含保守的半胱氨酸、组氨酸和天冬氨酸残基，依赖酸性pH环境发挥最佳活性。该基因突变可能导致酶活性丧失或异常，与多种疾病相关，例如神经元蜡样脂褐质沉积症（一种溶酶体贮积病）中CTSB功能缺陷会引发神经退行性变。此外，CTSB在癌症中常过表达，通过促进肿瘤侵袭和转移（如降解基底膜）与不良预后相关；其过表达还可能激活其他蛋白酶（如MMPs）或炎症因子（如IL-1β），加剧病理过程。相反，CTSB表达降低可能影响溶酶体清除功能，导致异常蛋白聚集（如阿尔茨海默病的β-淀粉样蛋白积累）。CTSB基因家族（C1A）成员均含有保守的半胱氨酸催化残基，多数为溶酶体蛋白酶，参与细胞内吞和自噬等过程。该家族成员（如CTSL、CTSK）在底物特异性上存在差异，但共同协调蛋白质代谢平衡。研究还发现CTSB与病毒感染有关，例如协助SARS-CoV-2等病毒进入细胞，使其成为潜在治疗靶点。调控CTSB表达或活性可能为癌症、神经退行性疾病和感染性疾病提供干预策略。

中文English

由该基因编码的蛋白质是二硫键连接的重链和轻链的二聚体，无论是从一个单一的蛋白前体产生的组成的溶酶体半胱氨酸蛋白酶。它也被称为淀粉状蛋白前体蛋白分泌酶和参与淀粉样前体蛋白（APP）的蛋白水解加工。 APP的不完全的蛋白水解加工已被建议是在阿尔茨海默病致病因子，老年痴呆症的最常见原因。所编码的蛋白质，它是肽酶的C1家族成员的过表达，一直与食管腺癌和其他肿瘤相关联。已发现此基因编码相同蛋白质至少五个转录变体。 [由RefSeq的，2008年7月提供]

OMIM数据库中对CTSB基因的介绍     Wikipedia数据库中对CTSB基因的介绍

基因序列

基因序列

CTSB基因的碱基序列：[NCBI]
Loading Gene Browser...

编码蛋白质

编码蛋白质

蛋白质序列
1MWQLWASLCC LLVLANARSR PSFHPLSDEL VNYVNKRNTT
41WQAGHNFYNV DMSYLKRLCG TFLGGPKPPQ RVMFTEDLKL
81 PASFDAREQ WPQCPTIKEI RDQGSCGSCW AFGAVEAISD
121RICIHTNAHV SVEVSAEDLL TCCGSMCGDG CNGGYPAEAW
161N FWTRKGLV SGGLYESHVG CRPYSIPPCE HHVNGSRPPC
201TGEGDTPKCS KICEPGYSPT YKQDKHYGYN SYSVSNSEKD
241IM AEIYKNG PVEGAFSVYS DFLLYKSGVY QHVTGEMMGG
281HAIRILGWGV ENGTPYWLVA NSWNTDWGDN GFFKILRGQD
321HCG IESEVV AGIPRTDQYW EKI
结构预测来自 AlphaFold DB（UniProt: P07858），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

基因突变

基因突变

CTSB基因的碱基突变：           仅显示部分snp
rs3947       rs4178       rs4839       rs4943       rs6730       rs6731       rs8005       rs8898       rs9009       rs12338       rs12898       rs13332       rs13361       rs17573       rs709821       rs709822       rs1004449      

基因表达

基因表达

CTSB基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
TACAACGTGGACATGAGCT
59
GTCCTCGGTAAACATAACTCTC
58
CCTCCCGAGTAGATACTTCTG
59
CTTCCTCAGTCACTGGGAG
59
AGCGAGAAGGACATCATGG
60
GGTACACTCCTGACTTGTAGAG
60
CCCGAGTAGTGGATCTAGGA
60
ATAGTTGACCAGCTCATCCG
60
TACAACGTGGACATGAGCT
59
GTCCTCGGTAAACATAACTCTC
58
TCTCAGCTCACTGCAACTC
60
ATCCTAGATCCACCTGTAATCG
59
TACAACGTGGACATGAGCT
59
GTCCTCGGTAAACATAACTCTC
58
TACAACGTGGACATGAGCT
59
GTCCTCGGTAAACATAACTCTC
58
AGCGAGAAGGACATCATGG
60
GGTACACTCCTGACTTGTAGAG
60
CTTTGCAGGTGGATCTAGG
58
CATAGTTGACCAGCTCATCC
58

转录因子

转录因子

转录因子
影响基因
影响类型
参考文献链接（PubMed）
ETS1
CTSB
Unknown
10701774
NFKB1
CTSB
Activation
15102937; 18598236
RELA
CTSB
Activation
15102937; 18598236
SP1
CTSB
Unknown
10701774
SP3
CTSB
Unknown
10701774
STAT1
CTSB
Unknown
11556541
USF1
CTSB
Unknown
14669984; 15276216
USF2
CTSB
Unknown
14669984; 15276216

基因本体信息

CTSB基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

CTSB基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0004197
E9PCB3 (UniProtKB)
IEA
GO:0006508
E9PCB3 (UniProtKB)
IEA
GO:0050790
E9PCB3 (UniProtKB)
IEA
GO:0004197
E9PHZ5 (UniProtKB)
IEA
GO:0005730
E9PHZ5 (UniProtKB)
IDA
GO:0006508
E9PHZ5 (UniProtKB)
IEA
GO:0043231
E9PHZ5 (UniProtKB)
IDA
GO:0050790
E9PHZ5 (UniProtKB)
IEA
GO:0004197
E9PIS1 (UniProtKB)
IEA
GO:0006508
E9PIS1 (UniProtKB)
IEA
GO:0050790
E9PIS1 (UniProtKB)
IEA
GO:0004197
E9PJ67 (UniProtKB)
IEA
GO:0006508
E9PJ67 (UniProtKB)
IEA
GO:0006508
E9PJ67 (UniProtKB)
IEA
GO:0050790
E9PJ67 (UniProtKB)
IEA
GO:0004197
E9PKQ7 (UniProtKB)
IEA
GO:0005730
E9PKQ7 (UniProtKB)
IDA
GO:0006508
E9PKQ7 (UniProtKB)
IEA
GO:0043231
E9PKQ7 (UniProtKB)
IDA
GO:0050790
E9PKQ7 (UniProtKB)
IEA
GO:0004197
E9PKX0 (UniProtKB)
IEA
GO:0006508
E9PKX0 (UniProtKB)
IEA
GO:0050790
E9PKX0 (UniProtKB)
IEA
GO:0004197
E9PL32 (UniProtKB)
IEA
GO:0006508
E9PL32 (UniProtKB)
IEA
GO:0050790
E9PL32 (UniProtKB)
IEA
GO:0004197
E9PLY3 (UniProtKB)
IEA
GO:0005730
E9PLY3 (UniProtKB)
IDA
GO:0006508
E9PLY3 (UniProtKB)
IEA
GO:0043231
E9PLY3 (UniProtKB)
IDA
GO:0050790
E9PLY3 (UniProtKB)
IEA
GO:0004197
E9PNL5 (UniProtKB)
IEA
GO:0005730
E9PNL5 (UniProtKB)
IDA
GO:0006508
E9PNL5 (UniProtKB)
IEA
GO:0043231
E9PNL5 (UniProtKB)
IDA
GO:0050790
E9PNL5 (UniProtKB)
IEA
GO:0004197
E9PQM1 (UniProtKB)
IEA
GO:0005730
E9PQM1 (UniProtKB)
IDA
GO:0006508
E9PQM1 (UniProtKB)
IEA
GO:0043231
E9PQM1 (UniProtKB)
IDA
GO:0050790
E9PQM1 (UniProtKB)
IEA
GO:0004197
E9PR54 (UniProtKB)
IEA
GO:0006508
E9PR54 (UniProtKB)
IEA
GO:0006508
E9PR54 (UniProtKB)
IEA
GO:0050790
E9PR54 (UniProtKB)
IEA
GO:0004197
E9PS78 (UniProtKB)
IEA
GO:0006508
E9PS78 (UniProtKB)
IEA
GO:0006508
E9PS78 (UniProtKB)
IEA
GO:0050790
E9PS78 (UniProtKB)
IEA
GO:0004197
E9PSG5 (UniProtKB)
IEA
GO:0005730
E9PSG5 (UniProtKB)
IDA
GO:0006508
E9PSG5 (UniProtKB)
IEA
GO:0043231
E9PSG5 (UniProtKB)
IDA
GO:0050790
E9PSG5 (UniProtKB)
IEA
GO:0002224
P07858 (UniProtKB)
TAS
GO:0004197
P07858 (UniProtKB)
IDA
GO:0004197
P07858 (UniProtKB)
IDA
GO:0004252
P07858 (UniProtKB)
TAS
GO:0004252
P07858 (UniProtKB)
TAS
GO:0005515
P07858 (UniProtKB)
IPI
GO:0005515
P07858 (UniProtKB)
IPI
GO:0005515
P07858 (UniProtKB)
IPI
GO:0005515
P07858 (UniProtKB)
IPI
GO:0005515
P07858 (UniProtKB)
IPI
GO:0005515
P07858 (UniProtKB)
IPI
GO:0005515
P07858 (UniProtKB)
IPI
GO:0005515
P07858 (UniProtKB)
IPI
GO:0005515
P07858 (UniProtKB)
IPI
GO:0005515
P07858 (UniProtKB)
IPI
GO:0005518
P07858 (UniProtKB)
IDA
GO:0005576
P07858 (UniProtKB)
TAS
GO:0005576
P07858 (UniProtKB)
TAS
GO:0005615
P07858 (UniProtKB)
ISS
GO:0005615
P07858 (UniProtKB)
IDA
GO:0005622
P07858 (UniProtKB)
TAS
GO:0005730
P07858 (UniProtKB)
IDA
GO:0005739
P07858 (UniProtKB)
IEA
GO:0005739
P07858 (UniProtKB)
IEA
GO:0005764
P07858 (UniProtKB)
IDA
GO:0005901
P07858 (UniProtKB)
IEA
GO:0006508
P07858 (UniProtKB)
IDA
GO:0006508
P07858 (UniProtKB)
IDA
GO:0006914
P07858 (UniProtKB)
IEA
GO:0007283
P07858 (UniProtKB)
IEA
GO:0007519
P07858 (UniProtKB)
IEA
GO:0008233
P07858 (UniProtKB)
IDA
GO:0008234
P07858 (UniProtKB)
IDA
GO:0008234
P07858 (UniProtKB)
IDA
GO:0009611
P07858 (UniProtKB)
IEA
GO:0009749
P07858 (UniProtKB)
IEA
GO:0009897
P07858 (UniProtKB)
IEA
GO:0014070
P07858 (UniProtKB)
IEA
GO:0014075
P07858 (UniProtKB)
IEA
GO:0016324
P07858 (UniProtKB)
IEA
GO:0030574
P07858 (UniProtKB)
IDA
GO:0030574
P07858 (UniProtKB)
TAS
GO:0030855
P07858 (UniProtKB)
IEP
GO:0030984
P07858 (UniProtKB)
IEA
GO:0036021
P07858 (UniProtKB)
TAS
GO:0042277
P07858 (UniProtKB)
IEA
GO:0042383
P07858 (UniProtKB)
IEA
GO:0042470
P07858 (UniProtKB)
IEA
GO:0042981
P07858 (UniProtKB)
TAS
GO:0043231
P07858 (UniProtKB)
IDA
GO:0043394
P07858 (UniProtKB)
IPI
GO:0043434
P07858 (UniProtKB)
IEA
GO:0043621
P07858 (UniProtKB)
IEA
GO:0045471
P07858 (UniProtKB)
IEA
GO:0046697
P07858 (UniProtKB)
IEA
GO:0046718
P07858 (UniProtKB)
IEA
GO:0048471
P07858 (UniProtKB)
IDA
GO:0050790
P07858 (UniProtKB)
IEA
GO:0051603
P07858 (UniProtKB)
IDA
GO:0060548
P07858 (UniProtKB)
IEA
GO:0070062
P07858 (UniProtKB)
IDA
GO:0070062
P07858 (UniProtKB)
IDA
GO:0070062
P07858 (UniProtKB)
IDA
GO:0070670
P07858 (UniProtKB)
IEA
GO:0071260
P07858 (UniProtKB)
IEA
GO:0097067
P07858 (UniProtKB)
IEP
GO:0006508
R4GMQ5 (UniProtKB)
IEA
GO:0008234
R4GMQ5 (UniProtKB)
IEA

基因相关microRNA

基因相关microRNA

可能调控 CTSB基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

String
BioGrid
IntAct
mentha
MINT
Reactome
加载中…
关联基因 作用方式 资源库来源/分值

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Glioblastoma 0.127348794 8 0 BeFree_CTD_human_LHGDN
Renal Cell Carcinoma 0.120542884 3 0 BeFree_CTD_human
Disease Progression 0.12 1 0 CTD_human
Prostatic Neoplasms 0.12 1 0 CTD_human
Myopathy 0.12 1 0 CTD_human
Neoplasm Invasiveness 0.12 2 0 CTD_human
Necrosis 0.12 1 0 CTD_human
Proteinuria 0.12 1 0 CTD_human
Glioma 0.086786047 26 0 BeFree_RGD
Liver carcinoma 0.080542884 3 1 BeFree_RGD

基因相关文献

基因相关文献

Bulk and single-cell transcriptome analyses combined with molecular simulations identify ferritinophagy as a key target for resveratrol in osteoarthritis.
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Baicalin chemosensitivity enhancement of cisplatin in bladder cancer via autophagy flux inhibition.
Zhuang J, Wang H, Chen Z, Wang J, Zheng X, He K, Xie D, Chen Q, Deng S, Wu J, Zheng X, Dai Y Front Pharmacol IF: 4.400 None
Cathepsin G Promotes Hepatic Lipid Deposition by Regulating Key Genes Related to Lipid Metabolism.
Yang W, Lin J, Pan Q, Jiang Y, Shi T, Cao X FASEB J IF: 4.3 2026-04-30
Therapeutic potential of exerkines in neurodegenerative and mental disorders: a narrative review.
Yang S, Sang HW, Kim S, Cho EJ, Choi Y, Kang DW, Jang YC, Park DH, Kwak HB, Yook JS Front Physiol IF: 4.134 None
Bisphenol S exposure before sexual maturity impairs follicular development via Cathepsin L-mediated granulosa cell death.
Li F, Shen F, Zhou Y, Zheng Y, Tian J, Li N, Tian Y, Peng Y, Zhang H, Li Q, Kong L, Duan S, Zhang L, Song D Ecotoxicol Environ Saf IF: 6.6 2026-03-15

基因相关服务

基因相关服务

基因相关评论

基因相关评论

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