CAMK2A (calcium/calmodulin dependent protein kinase II alpha)

基因基本信息

基因基本信息

symbol:
CAMK2A
locus group:
protein-coding gene
location:
5q32
gene_family:
alias symbol:
KIAA0968|CaMKIINalpha|CaMKIIα
alias name:
CaM-kinase II alpha chain|calciu...
entrez id:
815
ensembl gene id:
ENSG00000070808
ucsc gene id:
uc003lru.3
refseq accession:
NM_015981
hgnc_id:
HGNC:1460
approved reserved:
1993-11-24

基因染色体位置

基因染色体位置

5q32

基因简述

基因简述

CAMK2A（钙/钙调素依赖性蛋白激酶II α）是钙/钙调素依赖性蛋白激酶II（CaMKII）家族的重要成员，属于丝氨酸/苏氨酸蛋白激酶。该家族包括α、β、γ、δ四种亚型，共同特点是依赖钙离子（Ca²⁺）和钙调素（calmodulin）激活，并在神经元突触可塑性（如长时程增强LTP和长时程抑制LTD）中起核心作用。CAMK2A主要在大脑神经元中高表达，尤其在突触后密集区（PSD）富集，通过磷酸化靶蛋白（如AMPA受体、NMDA受体）调控突触强度和记忆形成。其功能特点是具有自磷酸化能力，即使钙信号消失仍可维持活性（ autonomy），这种特性对长期记忆存储至关重要。突变（如T286A）会阻断自磷酸化，导致LTP缺陷和学习障碍；人类CAMK2A突变与神经发育疾病（如智力障碍、自闭症、癫痫）相关。过表达可能引发异常神经元兴奋性（如癫痫样放电），而表达降低则损害突触可塑性和认知功能。该基因还通过调控CREB、ERK等信号通路影响基因转录。家族共性包括：多亚基（6-12个亚基）组成同源/异源寡聚体、受钙信号激活、参与细胞兴奋性调控。在阿尔茨海默病中，CAMK2A活性异常与β-淀粉样蛋白毒性相关。

中文English

该基因的产物属于丝氨酸/苏氨酸蛋白激酶家族，并以钙（2 +）/钙调蛋白依赖性蛋白激酶亚家族。钙信号是用于在谷氨酸突触可塑性的几个方面是至关重要的。这种钙调素依赖性蛋白激酶是由四个不同的链：α，β，γ，和三角洲。由该基因编码的α链是必需的海马长期增强（LTP）和空间学习。除了其钙 - 钙调蛋白（CaM的）依赖的活性，该蛋白可经历自磷酸化，从而导致钙调独立活动。编码不同的两种亚型变种成绩单已经确定了这个基因。 [由RefSeq的，2008年11月提供]

OMIM数据库中对CAMK2A基因的介绍     Wikipedia数据库中对CAMK2A基因的介绍

基因序列

基因序列

CAMK2A基因的碱基序列：[NCBI]
Loading Gene Browser...

编码蛋白质

编码蛋白质

蛋白质序列
1MATITCTRFT EEYQLFEELG KGAFSVVRRC VKVLAGQEYA
41AKIINTKKLS ARDHQKLERE ARICRLLKHP NIVRLHDSIS
81 EEGHHYLIF DLVTGGELFE DIVAREYYSE ADASHCIQQI
121LEAVLHCHQM GVVHRDLKPE NLLLASKLKG AAVKLADFGL
161A IEVEGEQQ AWFGFAGTPG YLSPEVLRKD PYGKPVDLWA
201CGVILYILLV GYPPFWDEDQ HRLYQQIKAG AYDFPSPEWD
241TV TPEAKDL INKMLTINPS KRITAAEALK HPWISHRSTV
281ASCMHRQETV DCLKKFNARR KLKGAILTTM LATRNFSGGK
321SGG NKKSDG VKESSESTNT TIEDEDTKVR KQEIIKVTEQ
361LIEAISNGDF ESYTKMCDPG MTAFEPEALG NLVEGLDFHR
401FYFE NLWSR NSKPVHTTIL NPHIHLMGDE SACIAYIRIT
441QYLDAGGIPR TAQSEETRVW HRRDGKWQIV HFHRSGAPSV
481LPH
结构预测来自 AlphaFold DB（UniProt: Q9UQM7），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

基因突变

基因突变

CAMK2A基因的碱基突变：           仅显示部分snp
rs15645       rs869191       rs869192       rs873592       rs873593       rs874083       rs874084       rs880100       rs882282       rs882663       rs882664       rs891934       rs891935       rs891936       rs891938       rs919740       rs919741      

基因表达

基因表达

CAMK2A基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
ATGGTGTGAAGGAATCCTCAG
60
CAATCAGCTGCTCTGTCAC
59
CGTTCAGTTAATGGAATCCTCAG
60
CAATCAGCTGCTCTGTCAC
59
GTCAGCCAGAGACCATCAG
60
TCTGAGATGCTGTCATGTAGTC
60
CTGTCAGCCAGAGTGAGAG
60
CTCAGGCCCTATACTCTAGC
59
CTGTATCCAGCAGATCCTG
57
AGATTCTCAGGCTTCAGGT
58
ACAAAGAAGCTGTCAGCCA
60
TGTAGTCGGACGATGTTGG
60
CAGCTCTTCGAGGAATTGG
58
TCATGTAGTCGGACTCTGG
58
CTGTATCCAGCAGATCCTG
57
AGATTCTCAGGCTTCAGGT
58
CATTCTCACCACGATGCTG
59
TCTGAGGATTCCTTCACACC
59
GTCCTACACGAAGATGTGC
58
GAATCGATGGAAGTCCAGG
58

转录因子

转录因子

      尚未收录相关数据

基因本体信息

CAMK2A基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

CAMK2A基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0004672
D6RFJ0 (UniProtKB)
IEA
GO:0005524
D6RFJ0 (UniProtKB)
IEA
GO:0006468
D6RFJ0 (UniProtKB)
IEA
GO:0004672
D6RHX9 (UniProtKB)
IEA
GO:0005524
D6RHX9 (UniProtKB)
IEA
GO:0006468
D6RHX9 (UniProtKB)
IEA
GO:0000082
Q9UQM7 (UniProtKB)
ISS
GO:0000165
Q9UQM7 (UniProtKB)
TAS
GO:0002931
Q9UQM7 (UniProtKB)
ISS
GO:0004674
Q9UQM7 (UniProtKB)
ISS
GO:0004674
Q9UQM7 (UniProtKB)
ISS
GO:0004674
Q9UQM7 (UniProtKB)
TAS
GO:0004683
Q9UQM7 (UniProtKB)
IEA
GO:0005088
Q9UQM7 (UniProtKB)
TAS
GO:0005515
Q9UQM7 (UniProtKB)
IPI
GO:0005515
Q9UQM7 (UniProtKB)
IPI
GO:0005516
Q9UQM7 (UniProtKB)
IPI
GO:0005524
Q9UQM7 (UniProtKB)
IEA
GO:0005634
Q9UQM7 (UniProtKB)
IDA
GO:0005654
Q9UQM7 (UniProtKB)
TAS
GO:0005654
Q9UQM7 (UniProtKB)
TAS
GO:0005739
Q9UQM7 (UniProtKB)
ISS
GO:0005829
Q9UQM7 (UniProtKB)
TAS
GO:0005829
Q9UQM7 (UniProtKB)
TAS
GO:0005829
Q9UQM7 (UniProtKB)
TAS
GO:0005829
Q9UQM7 (UniProtKB)
TAS
GO:0005829
Q9UQM7 (UniProtKB)
TAS
GO:0005829
Q9UQM7 (UniProtKB)
TAS
GO:0005829
Q9UQM7 (UniProtKB)
TAS
GO:0005829
Q9UQM7 (UniProtKB)
TAS
GO:0005829
Q9UQM7 (UniProtKB)
TAS
GO:0005829
Q9UQM7 (UniProtKB)
TAS
GO:0005829
Q9UQM7 (UniProtKB)
TAS
GO:0005886
Q9UQM7 (UniProtKB)
TAS
GO:0005886
Q9UQM7 (UniProtKB)
TAS
GO:0005886
Q9UQM7 (UniProtKB)
TAS
GO:0005886
Q9UQM7 (UniProtKB)
TAS
GO:0005886
Q9UQM7 (UniProtKB)
TAS
GO:0005886
Q9UQM7 (UniProtKB)
TAS
GO:0005886
Q9UQM7 (UniProtKB)
TAS
GO:0005886
Q9UQM7 (UniProtKB)
TAS
GO:0006468
Q9UQM7 (UniProtKB)
IDA
GO:0006816
Q9UQM7 (UniProtKB)
ISS
GO:0007223
Q9UQM7 (UniProtKB)
TAS
GO:0010666
Q9UQM7 (UniProtKB)
ISS
GO:0016301
Q9UQM7 (UniProtKB)
IDA
GO:0018105
Q9UQM7 (UniProtKB)
ISS
GO:0030054
Q9UQM7 (UniProtKB)
IEA
GO:0030666
Q9UQM7 (UniProtKB)
TAS
GO:0035254
Q9UQM7 (UniProtKB)
ISS
GO:0038166
Q9UQM7 (UniProtKB)
IDA
GO:0042734
Q9UQM7 (UniProtKB)
IEA
GO:0042803
Q9UQM7 (UniProtKB)
IPI
GO:0043547
Q9UQM7 (UniProtKB)
IEA
GO:0046777
Q9UQM7 (UniProtKB)
ISS
GO:0046928
Q9UQM7 (UniProtKB)
ISS
GO:0048168
Q9UQM7 (UniProtKB)
ISS
GO:0051092
Q9UQM7 (UniProtKB)
IMP
GO:0051928
Q9UQM7 (UniProtKB)
ISS
GO:0060333
Q9UQM7 (UniProtKB)
TAS
GO:0097481
Q9UQM7 (UniProtKB)
IEA
GO:1900034
Q9UQM7 (UniProtKB)
TAS
GO:1902108
Q9UQM7 (UniProtKB)
ISS

基因相关microRNA

基因相关microRNA

可能调控 CAMK2A基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

String
BioGrid
IntAct
mentha
MINT
Reactome
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关联基因 作用方式 资源库来源/分值

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Hepatolenticular Degeneration 0.12 1 0 CTD_human
Hyperalgesia 0.12 1 0 CTD_human
Obesity 0.12 1 1 GWASCAT
Cocaine-Related Disorders 0.12 1 0 CTD_human
Inflammation 0.08 1 0 RGD
Alzheimer's Disease 0.002995792 2 1 BeFree_LHGDN
Schizophrenia 0.00272435 1 0 LHGDN
Osteosarcoma 0.00272435 1 0 LHGDN
Squamous cell carcinoma 0.00272435 1 0 LHGDN
Bipolar Disorder 0.002638474 2 0 BeFree_GAD

基因相关文献

基因相关文献

A bioinspired anisotropic anti-inflammatory scaffold enhances spinal nerve regeneration and neural circuit reconstruction via FGF13/Ca2+/CaMK2A/CREB pathway.
Jiang M, Lu W, Zhuang J, Song J, Zhao Y, Zhou C, Zhou Y, Shu W, Zhu Z, Jiang L, Wu P, Wu A, Sheng S, Zhu S, Wang Z Mater Today Bio IF: 11.0 2026-04-00
Phosphoproteomic Analysis of Cortical Tissue from Mice Lacking Both CaMKIIα and CaMKIIβ Identifies Novel In Vivo Substrates.
Rigter PMF, Bezstarosti K, Koc OC, Perfitt TL, Demmers JAA, Colbran RJ, Stratton MM, Elgersma Y, van Woerden GM ACS Chem Neurosci IF: 4.5 2026-03-18
Time‑resolved multi-omic analysis of paclitaxel exposure in human iPSC‑derived sensory neurons unveils mechanisms of chemotherapy‑induced peripheral neuropathy.
Schinke C, Maierhof SK, Hew L, Fernandez Vallone V, Frahm S, Telugu NS, Diecke S, Ivanov A, Kovács R, Beule D, Kirchner M, Mertins P, Brüning U, Kirwan JA, Stachelscheid H, Endres M, Huehnchen P, Boehmerle W Cell Death Dis IF: 12.2 2026-02-10
CELF2-dependent RNA Regulation Supports Cortical Architecture and Synaptic Stability During Early Brain Development.
Syed I, Jiang J, Ko SH, Chen S, Zhang Z, Liu Z, Chen L Mol Neurobiol IF: 5.5 2026-05-26
circRNA-Associated ceRNA Regulatory Networks in Cardiac Responses to High-Altitude Hypoxia in Tibetan Pigs (Sus scrofa).
Li P, Cheng W, Shang P, Tao Z, Zhang H, Zhang B Int J Mol Sci IF: 3.226 2026-05-14
Translatome profiling reveals opposing alterations in inhibitory and excitatory neurons of fragile X mice and identifies EPAC2 as a therapeutic target.
Suresh A, Kourdougli N, Nomura T, Buth JE, Miranda-Rottmann S, Sánchez-León CA, Wu MW, Nelson SM, Wall LT, Tran AT, Araya R, Contractor A, Gandal MJ, Portera-Cailliau C Neuron IF: 16.9 2026-05-18
[CAMK2a Regulates Paclitaxel Resistance in Oral Squamous Cell Carcinoma Cells by Activating the ERK Signaling Pathway].
Wang J, Chen H, Chen J, Feng Y, Yuan Y, Zhang P Sichuan Da Xue Xue Bao Yi Xue Ban 2026-07-20
An Adnp frameshift variant disrupts Wnt signalling inducing chromatocytoskeletal defects and autism-related behaviour in male mice.
D'Incal CP, Cappuyns E, Paldi F, van der Lei MB, Annear DJ, Alastruey CM, Sokolova D, Elinck E, De Man K, Konings A, Huyghebaert J, Thys S, Pintelon I, Verschuuren M, Calus E, Van Dam D, De Deyn PP, Nguyen S, Yalcin B, Horii T, Hatada I, Mateiu L, Cavalli G, Pasciuto E, Berghe WV, Kooy RF EBioMedicine IF: 11.2 2026-06-00
Targeting the exosomal CaMK2A-ZDHHC3-GPX4 pathway reprograms tumor-associated macrophages and enhances anti-PD-1/PD-L1 immunotherapy in gastric cancer.
Chen Z, Huang H, Shen Y, Yamamoto M, Tsukamoto T, Nomura S, Jiang T, Xu Z, Li Z Int J Biol Sci IF: 11.7 None
A novel glioma prognosis marker CAMK2A is related to immune microenvironment and may be involved in Ras/Raf/MEK/ERK signaling.
Sun Z, Zhang J, Jin Q, Zhang A, Yao Z, Zhao Z, Ma Z, Hu J Sci Rep IF: 4.9 2026-06-25

基因相关服务

基因相关服务

基因相关评论

基因相关评论

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