CNTF (ciliary neurotrophic factor)

Gene Basic Information

Gene Basic Information

symbol
CNTF
locus group
protein-coding gene
location
11q12.1
gene_family
-
alias symbol
HCNTF
alias name
Ciliary Neuronotrophic Factor
entrez id
1270
ensembl gene id
ENSG00000242689
ucsc gene id
uc001nna.5
refseq accession
NM_000614
hgnc_id
HGNC:2169
approved reserved
1991-01-07

Chromosome Location

Chromosome Location

11q12.1

Gene Summary

Gene Summary

ChineseEnglish

The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of the upstream ZFP91 gene and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. [provided by RefSeq, Oct 2010]

OMIM entry for CNTF     Wikipedia entry for CNTF

Gene Sequence

Gene Sequence

Nucleotide sequence of CNTF:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MAFTEHSPLT PHRRDLCSRS IWLARKIRSD LTALTESYVK
41HQGLNKNINL DSADGMPVAS TDQWSELTEA ERLQENLQAY
81 RTFHVLLAR LLEDQQVHFT PTEGDFHQAI HTLLLQVAAF
121AYQIEELMIL LEYKIPRNEA DGMPINVGDG GLFEKKLWGL
161K VLQELSQW TVRSIHDLRF ISSHQTGIPA RGSHYIANNK
201KM
Structure predicted by AlphaFold DB(UniProt: P26441). Color indicates pLDDT confidence (dark blue = high, yellow/orange = low).

Gene Variants

Gene Variants

SNP variants of CNTF:           Showing partial SNPs
rs6266       rs588091       rs1064446       rs1800169       rs2507762       rs2509914       rs2515362       rs2515363       rs7113847       rs17152776       rs17152779       rs17489568       rs34131586       rs34494093       rs61889535       rs74410196       rs74670543      

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
TCTGTAGCCGCTCTATCTG
58
CCCTGATGCTTCACATAGGA
59
CTCTGTAGCCGCTCTATCTG
60
CTGATGCTTCACATAGGATTCC
59
CTGTAGCCGCTCTATCTGG
60
CCCTGATGCTTCACATAGGA
59

Gene Ontology

Subcellular localization of CNTF (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for CNTF:

GO ID
Protein
Source DB
GO:0005125
P26441 (UniProtKB)
IBA
GO:0005127
P26441 (UniProtKB)
TAS
GO:0005138
P26441 (UniProtKB)
IPI
GO:0005515
P26441 (UniProtKB)
IPI
GO:0005515
P26441 (UniProtKB)
IPI
GO:0005576
P26441 (UniProtKB)
TAS
GO:0005576
P26441 (UniProtKB)
TAS
GO:0005576
P26441 (UniProtKB)
TAS
GO:0005615
P26441 (UniProtKB)
IC
GO:0005737
P26441 (UniProtKB)
IEA
GO:0007165
P26441 (UniProtKB)
NAS
GO:0008083
P26441 (UniProtKB)
IDA
GO:0008284
P26441 (UniProtKB)
IBA
GO:0010628
P26441 (UniProtKB)
IDA
GO:0030424
P26441 (UniProtKB)
IBA
GO:0040007
P26441 (UniProtKB)
IEA
GO:0042517
P26441 (UniProtKB)
IDA
GO:0042517
P26441 (UniProtKB)
IDA
GO:0043524
P26441 (UniProtKB)
IDA
GO:0046533
P26441 (UniProtKB)
IEA
GO:0046668
P26441 (UniProtKB)
IEA
GO:0048143
P26441 (UniProtKB)
IBA
GO:0048644
P26441 (UniProtKB)
IEA
GO:0048666
P26441 (UniProtKB)
IEA
GO:0048680
P26441 (UniProtKB)
IBA
GO:0070120
P26441 (UniProtKB)
IDA
GO:0097058
P26441 (UniProtKB)
IDA

Gene Interactions

Gene Interactions

String
BioGrid
IntAct
mentha
MINT
Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
AMYOTROPHIC LATERAL SCLEROSIS 1 0.120542884 2 0 BeFree_CTD_human
Nerve Degeneration 0.12 1 0 CTD_human
Cerebral Hemorrhage 0.12 1 0 CTD_human
Huntington Disease 0.082995792 3 0 BeFree_LHGDN_RGD
Insulin Resistance 0.08 1 0 RGD
Glaucoma 0.08 1 0 RGD
Hyperglycemia 0.08 1 0 RGD
Schizophrenia 0.012268423 10 0 BeFree_GAD_LHGDN
Multiple Sclerosis 0.011268532 5 0 BeFree_GAD_LHGDN
Mental Depression 0.005005506 2 0 BeFree_GAD

Related Publications

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