DAP3 (death associated protein 3)
- symbol:
- DAP3
- locus group:
- protein-coding gene
- location:
- 1q22
- gene_family:
- Mitochondrial ribosomal proteins
- alias symbol:
- MRPS29|DAP-3|MRP-S29|bMRP-10|MGC126058|MGC126059|DKFZp686G12159
- alias name:
- mitochondrial 28S ribosomal protei…
- entrez id:
- 7818
- ensembl gene id:
- ENSG00000132676
- ucsc gene id:
- uc001flr.4
- refseq accession:
- NM_004632
- hgnc_id:
- HGNC:2673
- approved reserved:
- 1999-05-14
DAP3（Death Associated Protein 3）是一种线粒体核糖体蛋白，属于线粒体核糖体小亚基（28S）的组成部分，主要参与线粒体内蛋白质的翻译过程。它在维持线粒体功能、能量代谢和细胞凋亡调控中发挥重要作用。DAP3的表达产物是一种高度保守的蛋白质，广泛存在于真核生物中，其功能与线粒体呼吸链复合物的组装及细胞能量供应密切相关。DAP3的主要作用位点在线粒体基质中，通过与线粒体核糖体其他组分相互作用，促进线粒体编码蛋白的合成。DAP3的突变可能导致线粒体功能障碍，影响ATP生成，进而引发细胞凋亡异常或能量代谢疾病。研究表明，DAP3的异常表达与多种癌症相关，例如乳腺癌、肺癌和结直肠癌，其过表达可能抑制凋亡并促进肿瘤细胞存活，而表达降低则可能增强细胞对凋亡信号的敏感性。DAP3属于线粒体核糖体蛋白基因家族（MRP家族），该家族成员均参与线粒体蛋白质合成，共同特点是具有高度保守的序列和相似的线粒体定位信号。DAP3过表达可能通过抑制凋亡通路（如降低caspase活性）促进肿瘤发展，而表达降低可能导致线粒体功能缺陷，进而影响细胞能量稳态。此外，DAP3还参与调控其他线粒体相关基因的表达，如COX1和ND1，进一步影响氧化磷酸化过程。在神经退行性疾病中，DAP3表达异常可能与线粒体功能障碍导致的神经元凋亡有关。总体而言，DAP3是连接线粒体功能与细胞命运调控的关键分子，其表达水平需精确调控以维持细胞稳态。
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that also participates in apoptotic pathways which are initiated by tumor necrosis factor-alpha, Fas ligand, and gamma interferon. This protein potentially binds ATP/GTP and might be a functional partner of the mitoribosomal protein S27. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Pseudogenes corresponding to this gene are found on chromosomes 1q and 2q. [provided by RefSeq, Dec 2010]
Gene Ontology
Subcellular localization of DAP3 (and its protein):
- plasma membrane
- cytoplasm
- extracellular
- golgi
- vesicle
- cytoskeleton
- endoplasmic reticulum
- nucleus
- endosome
- lysosome
- mitochondrion
Gene Ontology (GO) terms for DAP3:
| Interacting Gene | Interaction | Source/Score |
| Name |
|---|
| Mitochondrial translation |
| Mitochondrial translation elongation |
| Mitochondrial translation initiation |
| Mitochondrial translation termination |
| Organelle biogenesis and maintenance |
| Disease | Score | NofPmids | NofSnps | Source |
| Mammary Neoplasms | 0.12 | 1 | 0 | CTD_human |
| Asthma | 0.005362824 | 1 | 0 | BeFree_GAD_LHGDN |
| Inflammation | 0.00272435 | 1 | 0 | LHGDN |
| Malignant neoplasm of prostate | 0.002367032 | 1 | 0 | GAD |
| Glioblastoma | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of breast | 0.000542884 | 2 | 0 | BeFree |
| Glioblastoma Multiforme | 0.000542884 | 2 | 0 | BeFree |
| Breast Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of stomach | 0.000271442 | 1 | 0 | BeFree |
| Thymoma | 0.000271442 | 1 | 0 | BeFree |
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: [email protected]
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
