DBH-AS1Gene Detail-Gene Database-Genelibs

DBH-AS1 (DBH antisense RNA 1)

symbol

DBH-AS1

locus group

non-coding RNA

location

9q34.2

gene_family

alias symbol

BPR

alias name

None

entrez id

138948

ensembl gene id

ENSG00000225756

ucsc gene id

uc031tfk.3

refseq accession

NR_002783

hgnc_id

HGNC:24155

approved reserved

2008-09-12

9q34.2

DBH-AS1是一种长链非编码RNA（lncRNA），位于人类9号染色体上，与多巴胺β-羟化酶（DBH）基因相邻，属于DBH基因家族的一部分。DBH基因家族主要参与儿茶酚胺类神经递质的合成，特别是将多巴胺转化为去甲肾上腺素的过程。DBH-AS1本身不编码蛋白质，但通过调控DBH基因的表达影响神经递质的合成与释放。DBH-AS1在多种组织中表达，尤其在肾上腺和脑部神经元中表达较高，与神经系统功能密切相关。研究表明，DBH-AS1通过表观遗传调控或竞争性结合miRNA等方式影响DBH的表达水平，进而调节去甲肾上腺素的生物合成。DBH-AS1的突变或表达异常可能与神经系统疾病相关，如帕金森病、精神分裂症和抑郁症，因为这些疾病常伴随儿茶酚胺代谢紊乱。当DBH-AS1过表达时，可能通过上调DBH增加去甲肾上腺素水平，导致焦虑、高血压或交感神经过度兴奋；而降低表达则可能减少去甲肾上腺素合成，引发低血压、注意力缺陷或情绪障碍。此外，DBH-AS1还可能通过调控其他邻近基因或参与染色质重塑影响更广泛的神经内分泌网络。DBH基因家族的共性在于它们均涉及儿茶酚胺代谢途径，对心血管、情绪和认知功能具有重要调控作用。目前对DBH-AS1的研究仍在深入，其在疾病诊断或治疗中的潜在价值有待进一步探索。

OMIM entry for DBH-AS1 Wikipedia entry for DBH-AS1

Nucleotide sequence of DBH-AS1:[NCBI]

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SNP variants of DBH-AS1: Showing partial SNPs

rs6271 rs129882 rs129914 rs129917 rs732833 rs1611131 rs2073832 rs2073833 rs2073837 rs2097628 rs2097629 rs3025417 rs3025418 rs3025419 rs3025421 rs3025422 rs3025423

Tissue expression of DBH-AS1: [UniProt]

Forward Primer

Forward Tm

Reverse Primer

Reverse Tm

Score

CTTGTTGCAGTGCATGGAG

CTTCGGGATCCTCTGTTCC

CTGAGGACTTGTTGCAGTG

CTTCGGGATCCTCTGTTCC

CTTGTTGCAGTGCATGGAG

CTTCGGGATCCTCTGTTCC

Disease

Score

NofPmids

NofSnps

Source

Disease	Score	NofPmids	NofSnps	Source
Malignant neoplasm of breast	0.000271442	1	0	BeFree
Mammary Neoplasms	0.000271442	1	0	BeFree
Breast Carcinoma	0.000271442	1	0	BeFree

Identification of hub mRNAs and long non-coding RNAs involved in temozolomide-resistant glioblastoma (brain cancer) cell lines.

Alamholo M, Tarinejad A Discov Oncol 2026-06-05

Development and validation of a phospholipid metabolism-associated lncRNA model for prognostic stratification and therapeutic guidance in HNSCC.

Zhang Y, Liu S, Song G, Wang K, Zhou Z, Xiao Y, Wu D World J Surg Oncol IF: 1.600 2026-03-12

Socceromics: A Systematic Review of Omics Technologies to Optimize Performance and Health in Soccer.

Owen A, Ceylan Hİ, Zmijewski P, Biz C, Sciarretta G, Rossin A, Ruggieri P, De Giorgio A, Trompetto C, Bragazzi NL, Puce L Int J Mol Sci IF: 3.226 2026-01-12

A2M-AS1, DBH-AS1, and NCBP2-AS2 in breast cancer: expression patterns, CA125-3 association, and a DBH-AS1-NCBP2-AS2 axis.

Badr EAE, Alashkar HG, El-Rebey HS, Khlosy EAE, Ghobashy EA, Abdelbary HM Mol Biol Rep IF: 3.2 2025-10-09

Bioinformatics Analysis of the Inflammation-Associated lncRNA-mRNA Coexpression Network in Type 2 Diabetes.

Huang L, Xiong S, Liu H, Li M, Zhang R, Liu Y, Hu X J Renin Angiotensin Aldosterone Syst IF: 10.6 2023-00-00

Candidate gene association study suggests potential role of dopamine beta-hydroxylase in pain heterogeneity in sickle cell disease.

Sadhu N, He Y, Yao Y, Wilkie DJ, Molokie RE, Wang ZJ Front Genet IF: 2.8 2023-00-00

Association Analyses of Predicted Loss-of-Function Variants Prioritized 15 Genes as Blood Pressure Regulators.

Lecluze E, Lettre G Can J Cardiol IF: 5.7 2023-00-00

Paclitaxel-resistant related lncRNA DBH-AS1 promotes the proliferation and invasion of esophageal cancer.

Lin ZX, Zhu LH, Huang JY, Huang YY, Lin X Eur Rev Med Pharmacol Sci 2022-00-00

Increased m6A modification of lncRNA DBH-AS1 suppresses pancreatic cancer growth and gemcitabine resistance via the miR-3163/USP44 axis.

Ye X, Wang LP, Han C, Hu H, Ni CM, Qiao GL, Ouyang L, Ni JS Ann Transl Med IF: nan 2022-03-00