DBHGene Detail-Gene Database-Genelibs

DBH (dopamine beta-hydroxylase)

symbol

DBH

locus group

protein-coding gene

location

9q34.2

gene_family

-

alias symbol

DBM

alias name

dopamine beta-monooxygenase

entrez id

1621

ensembl gene id

ENSG00000123454

ucsc gene id

uc004cel.4

refseq accession

NM_000787

hgnc_id

HGNC:2689

approved reserved

2001-06-22

9q34.2

ChineseEnglish

The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. It is present in the synaptic vesicles of postganglionic sympathetic neurons and converts dopamine to norepinephrine. It exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. [provided by RefSeq, Jul 2008]

OMIM entry for DBH Wikipedia entry for DBH

Nucleotide sequence of DBH:[NCBI]

Loading Gene Browser...

Protein Sequence

1MPALSRWASL PGPSMREAAF MYSTAVAIFL VILVAALQGS
41APRESPLPYH IPLDPEGSLE LSWNVSYTQE AIHFQLLVRR
81
LKAGVLFGM SDRGELENAD LVVLWTDGDT AYFADAWSDQ
121KGQIHLDPQQ DYQLLQVQRT PEGLTLLFKR PFGTCDPKDY
161L
IEDGTVHL VYGILEEPFR SLEAINGSGL QMGLQRVQLL
201KPNIPEPELP SDACTMEVQA PNIQIPSQET TYWCYIKELP
241KG
FSRHHII KYEPIVTKGN EALVHHMEVF QCAPEMDSVP
281HFSGPCDSKM KPDRLNYCRH VLAAWALGAK AFYYPEEAGL
321AFG
GPGSSR YLRLEVHYHN PLVIEGRNDS SGIRLYYTAK
361LRRFNAGIME LGLVYTPVMA IPPRETAFIL TGYCTDKCTQ
401LALP
PSGIH IFASQLHTHL TGRKVVTVLV RDGREWEIVN
441QDNHYSPHFQ EIRMLKKVVS VHPGDVLITS CTYNTEDREL
481ATVGG
FGIL EEMCVNYVHY YPQTQLELCK SAVDAGFLQK
521YFHLINRFNN EDVCTCPQAS VSQQFTSVPW NSFNRDVLKA
561LYSFAP
ISM HCNKSSAVRF QGEWNLQPLP KVISTLEEPT
601PQCPTSQGRS PAGPTVVSIG GGKG

Structure predicted by AlphaFold DB(UniProt: P09172). Color indicates pLDDT confidence (dark blue = high, yellow/orange = low).

SNP variants of DBH: Showing partial SNPs

rs6271 rs129882 rs129914 rs129917 rs732833 rs1611131 rs2073832 rs2073833 rs2073837 rs2097628 rs2097629 rs3025417 rs3025418 rs3025419 rs3025421 rs3025422 rs3025423

Tissue expression of DBH: [UniProt]

Forward Primer

Forward Tm

Reverse Primer

Reverse Tm

Score

AAGCTCCCAATATCCAGATCC

60

GGGCTCGTACTTGATAATGTG

59

AGCTCCCAATATCCAGATCC

59

GGGCTCGTACTTGATAATGTG

59

GCTCCCAATATCCAGATCCC

60

GGGCTCGTACTTGATAATGTG

59

Transcription Factors

Target Gene

Interaction Type

PubMed References

HAND2

DBH

Activation

14512028

PHOX2A

DBH

Activation

16280598

PHOX2A

DBH

Unknown

11034547

PHOX2B

DBH

Activation

11034547; 16280598

PHOX2B

DBH

Unknown

15888479

TFAP2A

DBH

Unknown

11146001

YY1

DBH

Activation

8753872

Subcellular localization of DBH (and its protein):

[UniProt] [GenomeNet]

plasma membrane
cytoplasm
extracellular
golgi
vesicle
cytoskeleton
endoplasmic reticulum
nucleus
endosome
lysosome
mitochondrion

Gene Ontology (GO) terms for DBH:

GO ID

Protein

Source DB

GO:0001816

P09172 (UniProtKB)

IEA

GO:0001974

P09172 (UniProtKB)

IEA

GO:0001975

P09172 (UniProtKB)

IEA

GO:0002443

P09172 (UniProtKB)

IEA

GO:0003824

P09172 (UniProtKB)

TAS

GO:0004500

P09172 (UniProtKB)

TAS

GO:0005507

P09172 (UniProtKB)

IEA

GO:0005576

P09172 (UniProtKB)

NAS

GO:0005737

P09172 (UniProtKB)

TAS

GO:0007268

P09172 (UniProtKB)

TAS

GO:0007613

P09172 (UniProtKB)

IEA

GO:0007626

P09172 (UniProtKB)

IEA

GO:0008542

P09172 (UniProtKB)

IEA

GO:0016020

P09172 (UniProtKB)

TAS

GO:0016021

P09172 (UniProtKB)

IEA

GO:0030658

P09172 (UniProtKB)

IEA

GO:0031418

P09172 (UniProtKB)

IEA

GO:0034466

P09172 (UniProtKB)

IEA

GO:0034774

P09172 (UniProtKB)

TAS

GO:0042127

P09172 (UniProtKB)

IEA

GO:0042309

P09172 (UniProtKB)

IEA

GO:0042420

P09172 (UniProtKB)

IEA

GO:0042421

P09172 (UniProtKB)

IEA

GO:0042423

P09172 (UniProtKB)

TAS

GO:0042584

P09172 (UniProtKB)

IEA

GO:0042593

P09172 (UniProtKB)

IEA

GO:0042596

P09172 (UniProtKB)

IEA

GO:0042711

P09172 (UniProtKB)

IEA

GO:0045907

P09172 (UniProtKB)

IEA

GO:0048149

P09172 (UniProtKB)

IEA

GO:0048265

P09172 (UniProtKB)

IEA

GO:0050900

P09172 (UniProtKB)

IEA

GO:0055114

P09172 (UniProtKB)

IEA

GO:2001236

P09172 (UniProtKB)

IEA

GO:0005507

Q5T382 (UniProtKB)

IEA

GO:0016715

Q5T382 (UniProtKB)

IEA

GO:0055114

Q5T382 (UniProtKB)

IEA

microRNAs potentially regulating DBH:

hsa-miR-335

String

BioGrid

mentha

MINT

Reactome

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Interacting Gene	Interaction	Source/Score

KEGG
Reactomepathway

Name
350 Tyrosine metabolism [PATH:hsa00350]

Name
Amine-derived hormones
Catecholamine biosynthesis
Metabolism
Metabolism of amino acids and derivatives

Disease

Score

NofPmids

NofSnps

Source

Disease	Score	NofPmids	NofSnps	Source
dopamine beta hydroxylase deficiency	0.440271442	2	0	BeFree_CTD_human_MGD_ORPHANET_UNIPROT
Paranoia	0.123724241	5	0	BeFree_CTD_human_GAD
Neuroblastoma	0.122171535	9	0	BeFree_CTD_human
Pheochromocytoma	0.121085767	5	0	BeFree_CTD_human
Peripheral Neuropathy	0.12	1	0	CTD_human
PARKINSON DISEASE, LATE-ONSET	0.12	0	0	CTD_human
Hypertensive disease	0.085634266	3	0	BeFree_GAD_LHGDN_RGD
Depressive disorder	0.080542884	3	0	BeFree_RGD
Hypertension, Portal	0.08	1	0	RGD
Liver Cirrhosis, Experimental	0.08	1	0	RGD

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DBH (dopamine beta-hydroxylase)

Gene Basic Information

Gene Basic Information

Chromosome Location

Chromosome Location

Gene Summary

Gene Summary

Gene Sequence

Gene Sequence

Encoded Protein

Encoded Protein

Gene Variants

Gene Variants

Gene Expression

Gene Expression

Gene Primers

Gene Primers

Transcription Factors

Transcription Factors

Gene Ontology

Related microRNA

Related microRNA

Gene Interactions

Gene Interactions

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Gene Pathways

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