DOCK7 (dedicator of cytokinesis 7)

基因基本信息

基因基本信息

symbol:
DOCK7
locus group:
protein-coding gene
location:
1p31.3
gene_family:
alias symbol:
KIAA1771|ZIR2
alias name:
None
entrez id:
85440
ensembl gene id:
ENSG00000116641
ucsc gene id:
uc001dap.6
refseq accession:
NM_033407
hgnc_id:
HGNC:19190
approved reserved:
2003-11-19

基因染色体位置

基因染色体位置

1p31.3

基因简述

基因简述

DOCK7（Dedicator of Cytokinesis 7）属于DOCK基因家族，该家族共有11个成员（DOCK1-11），其共同特点是作为鸟苷酸交换因子（GEF），通过激活Rho家族小GTP酶（如Rac1、Cdc42）调控细胞骨架重组、细胞迁移和神经发育等过程。DOCK7在神经系统中高度表达，尤其在发育中的大脑皮层和海马区，通过激活Rac1和Cdc42调控神经元极性建立、轴突生长和树突发育。其表达产物是一种约220kDa的蛋白质，含有DOCK家族特有的DHR-2结构域（直接结合GTP酶）和SH3结构域（介导蛋白相互作用）。DOCK7突变可导致神经发育异常，如小鼠模型中敲除该基因会引发皮层神经元迁移障碍，类似人类无脑回畸形；某些错义突变（如R1116H）会削弱其GEF活性，与癫痫和智力障碍相关。该基因过表达可能促进肿瘤侵袭转移，例如在胶质瘤中通过Rac1/PAK通路增强细胞迁移能力；而表达降低则可能影响突触可塑性，与自闭症谱系障碍有关。DOCK7还与阿尔茨海默病相关，其表达下调会加剧β-淀粉样蛋白毒性导致的神经元损伤。该基因受miR-34a等microRNA调控，并能与CRMP2、TUBB3等微管相关蛋白相互作用，共同协调微管动力学。在非神经组织中，DOCK7参与脂肪细胞分化，其抑制可减少脂滴积累。药物开发中针对DOCK7-Rac1相互作用界面的抑制剂正被研究用于抗肿瘤转移。

中文English

由该基因编码的蛋白质是一个鸟嘌呤核苷酸交换因子（GEF），发挥在轴突的形成和神经元极化的作用。该编码的蛋白显示GEF活性对RAC1和RAC3卢小GTP酶，但不计入CDC42。已发现该基因编码不同亚型的几个抄本变形。 [由RefSeq的，2012年12月提供]

OMIM数据库中对DOCK7基因的介绍     Wikipedia数据库中对DOCK7基因的介绍

基因序列

基因序列

DOCK7基因的碱基序列：[NCBI]
Loading Gene Browser...

编码蛋白质

编码蛋白质

蛋白质序列
1MAERRAFAQK ISRTVAAEVR KQISGQYSGS PQLLKNLNIV
41GNISHHTTVP LTEAVDPVDL EDYLITHPLA VDSGPLRDLI
81 EFPPDDIEV VYSPRDCRTL VSAVPEESEM DPHVRDCIRS
121YTEDWAIVIR KYHKLGTGFN PNTLDKQKER QKGLPKQVFE
161S DEAPDGNS YQDDQDDLKR RSMSIDDTPR GSWACSIFDL
201KNSLPDALLP NLLDRTPNEE IDRQNDDQRK SNRHKELFAL
241HP SPDEEEP IERLSVPDIP KEHFGQRLLV KCLSLKFEIE
281IEPIFASLAL YDVKEKKKIS ENFYFDLNSE QMKGLLRPHV
321PPA AITTLA RSAIFSITYP SQDVFLVIKL EKVLQQGDIG
361ECAEPYMIFK EADATKNKEK LEKLKSQADQ FCQRLGKYRM
401PFAW TAIHL MNIVSSAGSL ERDSTEVEIS TGERKGSWSE
441RRNSSIVGRR SLERTTSGDD ACNLTSFRPA TLTVTNFFKQ
481EGDRL SDED LYKFLADMRR PSSVLRRLRP ITAQLKIDIS
521PAPENPHYCL TPELLQVKLY PDSRVRPTRE ILEFPARDVY
561VPNTTY RNL LYIYPQSLNF ANRQGSARNI TVKVQFMYGE
601DPSNAMPVIF GKSSCSEFSK EAYTAVVYHN RSPDFHEEIK
641VKLPATL TD HHHLLFTFYH VSCQQKQNTP LETPVGYTWI
681PMLQNGRLKT GQFCLPVSLE KPPQAYSVLS PEVPLPGMKW
721VDNHKGVF N VEVVAVSSIH TQDPYLDKFF ALVNALDEHL
761FPVRIGDMRI MENNLENELK SSISALNSSQ LEPVVRFLHL
801LLDKLILLV IRPPVIAGQI VNLGQASFEA MASIINRLHK
841NLEGNHDQHG RNSLLASYIH YVFRLPNTYP NSSSPGPGGL
881GGSVHYATMA RSAVRPASL NLNRSRSLSN SNPDISGTPT
921SPDDEVRSII GSKGLDRSNS WVNTGGPKAA PWGSNPSPSA
961ESTQAMDRSC N RMSSHTET SSFLQTLTGR LPTKKLFHEE
1001LALQWVVCSG SVRESALQQA WFFFELMVKS MVHHLYFNDK
1041LEAPRKSRFP ER FMDDIAA LVSTIASDIV SRFQKDTEMV
1081ERLNTSLAFF LNDLLSVMDR GFVFSLIKSC YKQVSSKLYS
1121LPNPSVLVSL RLD FLRIIC SHEHYVTLNL PCSLLTPPAS
1161PSPSVSSATS QSSGFSTNVQ DQKIANMFEL SVPFRQQHYL
1201AGLVLTELAV ILDP DAEGL FGLHKKVINM VHNLLSSHDS
1241DPRYSDPQIK ARVAMLYLPL IGIIMETVPQ LYDFTETHNQ
1281RGRPICIATD DYESE SGSM ISQTVAMAIA GTSVPQLTRP
1321GSFLLTSTSG RQHTTFSAES SRSLLICLLW VLKNADETVL
1361QKWFTDLSVL QLNRLL DLL YLCVSCFEYK GKKVFERMNS
1401LTFKKSKDMR AKLEEAILGS IGARQEMVRR SRGQLGTYTI
1441ASPPERSPSG SAFGSQE NL RWRKDMTHWR QNTEKLDKSR
1481AEIEHEALID GNLATEANLI ILDTLEIVVQ TVSVTESKES
1521ILGGVLKVLL HSMACNQS A VYLQHCFATQ RALVSKFPEL
1561LFEEETEQCA DLCLRLLRHC SSSIGTIRSH ASASLYLLMR
1601QNFEIGNNFA RVKMQVTMS LSSLVGTSQN FNEEFLRRSL
1641KTILTYAEED LELRETTFPD QVQDLVFNLH MILSDTVKMK
1681EHQEDPEMLI DLMYRIAKGY QTSPDLRLT WLQNMAGKHS
1721ERSNHAEAAQ CLVHSAALVA EYLSMLEDRK YLPVGCVTFQ
1761NISSNVLEES AVSDDVVSPD E EGICSGKY FTESGLVGLL
1801EQAAASFSMA GMYEAVNEVY KVLIPIHEAN RDAKKLSTIH
1841GKLQEAFSKI VHQSTGWERM FG TYFRVGF YGTKFGDLDE
1881QEFVYKEPAI TKLAEISHRL EGFYGERFGE DVVEVIKDSN
1921PVDKCKLDPN KAYIQITYVE PYF DTYEMK DRITYFDKNY
1961NLRRFMYCTP FTLDGRAHGE LHEQFKRKTI LTTSHAFPYI
2001KTRVNVTHKE EIILTPIEVA IEDM QKKTQ ELAFATHQDP
2041ADPKMLQMVL QGSVGTTVNQ GPLEVAQVFL SEIPSDPKLF
2081RHHNKLRLCF KDFTKRCEDA LRKNK SLIG PDQKEYQREL
2121ERNYHRLKEA LQPLINRKIP QLYKAVLPVT CHRDSFSRMS
2161LRKMDL
结构预测来自 AlphaFold DB（UniProt: Q96N67），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

基因突变

基因突变

DOCK7基因的碱基突变：           仅显示部分snp
rs4145257       rs10449755       rs10789117       rs11207997       rs12023629       rs12563308       rs12565895       rs17123721       rs17123725       rs17123728       rs34364551       rs34483103       rs34898550       rs34927999       rs35123493       rs35285100       rs67461605      

基因表达

基因表达

DOCK7基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
AGACTCTAATCCTGTAGACAAGTG
60
GGCTCCACATAGGTAATCTG
58
GTAGAAATCAGTACTGGAGAACG
59
TTCAAGTGATCGTCTGCCA
59
TAGCTTCTCCTCCTGAGAG
57
GAGTCATATCTTTCCTCCACC
58
GAGATATCTCACAGATTGGAGG
58
CTTCAACCACATCCTCTCCA
60
CTGGGTTAACACTGGTGGT
60
ACTTCGATCCATAGCCTGTG
60
CATCATCACCAGGTCCTGG
60
TTACTAAGGCTTCGAGAACGA
59
GTACCTGAAGAAAGTGAAATGG
57
TTTCTGATGACAATTGCCCA
58
CCGATTTCTTCATCTTCTGCT
59
CTAGGTTAACTATTTGGCCAGC
59
GTGGGATGTGTAACATTTCAG
57
ACCACATCATCTGAGACCG
59
TGAAGCTAATCGGGATGCA
59
ACATCCGCTTACCATCCTG
60

转录因子

转录因子

      尚未收录相关数据

基因本体信息

DOCK7基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

DOCK7基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0005085
A0A0C4DGY6 (UniProtKB)
IEA
GO:0005622
A0A0C4DGY6 (UniProtKB)
IEA
GO:0007264
A0A0C4DGY6 (UniProtKB)
IEA
GO:0043547
A0A0C4DGY6 (UniProtKB)
IEA
GO:0005085
A0A0U1RQG7 (UniProtKB)
IEA
GO:0005622
A0A0U1RQG7 (UniProtKB)
IEA
GO:0007264
A0A0U1RQG7 (UniProtKB)
IEA
GO:0043547
A0A0U1RQG7 (UniProtKB)
IEA
GO:0005085
A0A0U1RQJ5 (UniProtKB)
IEA
GO:0005622
A0A0U1RQJ5 (UniProtKB)
IEA
GO:0007264
A0A0U1RQJ5 (UniProtKB)
IEA
GO:0043547
A0A0U1RQJ5 (UniProtKB)
IEA
GO:0005085
A0A0U1RQT6 (UniProtKB)
IEA
GO:0005622
A0A0U1RQT6 (UniProtKB)
IEA
GO:0007264
A0A0U1RQT6 (UniProtKB)
IEA
GO:0043547
A0A0U1RQT6 (UniProtKB)
IEA
GO:0005085
A0A0U1RR97 (UniProtKB)
IEA
GO:0005622
A0A0U1RR97 (UniProtKB)
IEA
GO:0007264
A0A0U1RR97 (UniProtKB)
IEA
GO:0043547
A0A0U1RR97 (UniProtKB)
IEA
GO:0005085
A0A0U1RRC1 (UniProtKB)
IEA
GO:0005622
A0A0U1RRC1 (UniProtKB)
IEA
GO:0007264
A0A0U1RRC1 (UniProtKB)
IEA
GO:0043547
A0A0U1RRC1 (UniProtKB)
IEA
GO:0005085
H0Y7L2 (UniProtKB)
IEA
GO:0005622
H0Y7L2 (UniProtKB)
IEA
GO:0007264
H0Y7L2 (UniProtKB)
IEA
GO:0043547
H0Y7L2 (UniProtKB)
IEA
GO:0000226
Q96N67 (UniProtKB)
IMP
GO:0005085
Q96N67 (UniProtKB)
IEA
GO:0005925
Q96N67 (UniProtKB)
IDA
GO:0007264
Q96N67 (UniProtKB)
IEA
GO:0007409
Q96N67 (UniProtKB)
IMP
GO:0022027
Q96N67 (UniProtKB)
ISS
GO:0030424
Q96N67 (UniProtKB)
TAS
GO:0030426
Q96N67 (UniProtKB)
TAS
GO:0031175
Q96N67 (UniProtKB)
IMP
GO:0033138
Q96N67 (UniProtKB)
IMP
GO:0043005
Q96N67 (UniProtKB)
TAS
GO:0045178
Q96N67 (UniProtKB)
TAS
GO:0045200
Q96N67 (UniProtKB)
IMP
GO:0048365
Q96N67 (UniProtKB)
IDA
GO:0050767
Q96N67 (UniProtKB)
ISS
GO:0090630
Q96N67 (UniProtKB)
IDA
GO:1904754
Q96N67 (UniProtKB)
IMP
GO:0008180
Q96N67 (UniProtKB)
IDA

基因相关microRNA

基因相关microRNA

可能调控 DOCK7基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

String
BioGrid
IntAct
mentha
MINT
加载中…
关联基因 作用方式 资源库来源/分值

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 23 0.12 0 0 ORPHANET
Platelet Storage Pool Deficiency 0.08 0 0 MGD
Tobacco Use Disorder 0.002367032 1 0 GAD
Glioblastoma 0.000271442 1 0 BeFree
Blindness, Cortical 0.000271442 1 0 BeFree
Epileptic encephalopathy 0.000271442 1 0 BeFree
Non-Neoplastic Disorder 0.000271442 1 0 BeFree

基因相关文献

基因相关文献

The E3 Ubiquitin Ligase UBE3B Regulates Synaptic Development and Cortical Network Activity.
Vashisth S, Shedd A, Aiken A, Cheon S, Bandopadhay J, Kaur K, Huber KM, Chahrour MH Autism Res IF: 3.9 2026-05-00
A role for Keratin 17 in Rac1-mediated DNA damage response in keratinocytes.
Pineda C, Cohen E, Su B, Yeom J, Kim J, Lee CH, Coulombe PA Mol Biol Cell IF: 3.0 2026-05-01
Global Phosphoproteome Analysis Identifies CLK4 Co-Regulatory Pathways Driving Tumor-Specific Dysregulation.
Pai A, Dcunha L, Gopalakrishnan AP, Ummar S, Rajeev AC, Raju R OMICS IF: 2.0 2026-10-00
Deletion of Dock7 Exons 3 and 4 Results in Reduced Trabecular Microarchitecture and a Decrease in Mineralization.
Lizotte T, Lajoie C, Porter S, Lang S, Vesper FA, Brooks DJ, Gartner C, Alexander MS, Vary C, Bouxsein ML, Becker KA bioRxiv 2026-01-02
Genome Wide Association Analysis Reveals New Production Trait Genes in a Male Duroc Population.
Wang Kejun, Liu Dewu, Hernandez-Sanchez Jules, Chen Jie, Liu Chengkun, Wu Zhenfang, Fang Meiying, Li Ning PLoS One IF: 2.6 2016-06-14
Importance of defining experimental conditions in a mouse excisional wound model.
Park Shin Ae, Covert Jill, Teixeira Leandro, Motta Monica J, DeRemer Sara L, Abbott Nicholas L, Dubielzig Richard, Schurr Michael, Isseroff Roslyn Rivkah, McAnulty Jonathan F, Murphy Christopher J Wound Repair Regen IF: 4.3 2016-05-10
Genetic Variants Associated with Lipid Profiles in Chinese Patients with Type 2 Diabetes.
Kong Xiaomu, Zhao Qi, Xing Xiaoyan, Zhang Bo, Zhang Xuelian, Hong Jing, Yang Wenying PLoS One IF: 2.6 2016-05-23
Endothelial RhoGEFs: A systematic analysis of their expression profiles in VEGF-stimulated and tumor endothelial cells.
Hernández-García Ricardo, Iruela-Arispe M Luisa, Reyes-Cruz Guadalupe, Vázquez-Prado José Vascul Pharmacol IF: 3.7 2016-09-08
Interaction of myosin VI and its binding partner DOCK7 plays an important role in NGF-stimulated protrusion formation in PC12 cells.
Sobczak Magdalena, Chumak Vira, Pomorski Paweł, Wojtera Emilia, Majewski Łukasz, Nowak Jolanta, Yamauchi Junji, Rędowicz Maria Jolanta Biochim Biophys Acta 2016-09-08

基因相关服务

基因相关服务

基因相关评论

基因相关评论

评论加载中...

登录后即可发表评论 登录 注册

联系地址

山东省济南市章丘区文博路2号

齐鲁师范学院 genelibs生信实验室

山东省济南市高新区舜华路750号

大学科技园北区F座4单元2楼

电话： 0531-88819269

微信公众号

关注微信订阅号，实时查看信息，关注医学生物学动态。


商务邮箱

E-mail: [email protected]

版权所有 © 2025.Genelibs 济南弘晖生物技术有限公司 鲁ICP备20007159号-2