DCC (DCC netrin 1 receptor)

基因基本信息

基因基本信息

symbol:
DCC
locus group:
protein-coding gene
location:
18q21.2
gene_family:
Fibronectin type III domain containing|I-set domain containing|Immunoglobulin-like domain containing
alias symbol:
IGDCC1|NTN1R1
alias name:
immunoglobulin superfamily, DCC ...
entrez id:
1630
ensembl gene id:
ENSG00000187323
ucsc gene id:
uc002lfe.3
refseq accession:
NM_005215
hgnc_id:
HGNC:2701
approved reserved:
1990-05-25

基因染色体位置

基因染色体位置

18q21.2

基因简述

基因简述

DCC（Deleted in Colorectal Cancer）基因位于人类18号染色体上，编码一种跨膜蛋白受体，属于神经生长因子受体（NGF receptor）家族中的一员，与netrin-1受体家族相关。DCC蛋白在神经系统中发挥重要作用，参与轴突导向和神经元迁移，帮助引导神经纤维向正确方向生长。此外，它在结肠和其他组织中也有表达，被认为具有抑癌作用。DCC蛋白通过与配体netrin-1结合激活下游信号通路，调控细胞黏附、迁移和凋亡。DCC基因突变或表达缺失与多种癌症密切相关，尤其是结直肠癌，其名称正是源于在结直肠癌中常发现该基因的缺失。突变可能导致DCC功能丧失，破坏细胞正常凋亡过程，促进肿瘤发生。DCC表达降低还与胃癌、胰腺癌等恶性肿瘤进展相关。过表达DCC可抑制肿瘤细胞增殖并诱导凋亡，而低表达则可能削弱其抑癌作用，导致细胞异常增殖和转移。在神经系统发育中，DCC表达异常可能影响神经回路形成，与某些神经发育障碍有关。DCC属于免疫球蛋白超家族（IgSF），该家族成员通常含有免疫球蛋白样结构域，参与细胞间识别和信号传导。DCC与同家族成员如neogenin共享部分功能，如介导细胞-细胞相互作用。DCC基因的甲基化沉默是癌症中其表达缺失的常见机制。此外，DCC单核苷酸多态性（SNP）可能与精神分裂症等神经精神疾病易感性相关。在动物模型中，DCC敲除会导致轴突导向缺陷和神经发育异常，进一步证实其在神经系统中的关键作用。

中文English

该基因编码一个导蛋白受体。跨膜蛋白是细胞粘附分子的免疫球蛋白超家族中的一员，并介导的神经元生长锥轴突导向朝向的netrin 1配体的来源。胞质尾相互作用用酪氨酸激酶Src和粘着斑激酶（FAK，也称为PTK2）介导轴突吸引力。该PROTEIN部分定位于脂筏，并且在不存在配体诱导凋亡。蛋白质的功能作为一个肿瘤抑制，并且经常发生突变或大肠癌和食管癌下调。 [由RefSeq的，2009年10月提供]

OMIM数据库中对DCC基因的介绍     Wikipedia数据库中对DCC基因的介绍

基因序列

基因序列

DCC基因的碱基序列：[NCBI]
Loading Gene Browser...

编码蛋白质

编码蛋白质

蛋白质序列
1MENSLRCVWV PKLAFVLFGA SLFSAHLQVT GFQIKAFTAL
41RFLSEPSDAV TMRGGNVLLD CSAESDRGVP VIKWKKDGIH
81 LALGMDERK QQLSNGSLLI QNILHSRHHK PDEGLYQCEA
121SLGDSGSIIS RTAKVAVAGP LRFLSQTESV TAFMGDTVLL
161K CEVIGEPM PTIHWQKNQQ DLTPIPGDSR VVVLPSGALQ
201ISRLQPGDIG IYRCSARNPA SSRTGNEAEV RILSDPGLHR
241QL YFLQRPS NVVAIEGKDA VLECCVSGYP PPSFTWLRGE
281EVIQLRSKKY SLLGGSNLLI SNVTDDDSGM YTCVVTYKNE
321NIS ASAELT VLVPPWFLNH PSNLYAYESM DIEFECTVSG
361KPVPTVNWMK NGDVVIPSDY FQIVGGSNLR ILGVVKSDEG
401FYQC VAENE AGNAQTSAQL IVPKPAIPSS SVLPSAPRDV
441VPVLVSSRFV RLSWRPPAEA KGNIQTFTVF FSREGDNRER
481ALNTT QPGS LQLTVGNLKP EAMYTFRVVA YNEWGPGESS
521QPIKVATQPE LQVPGPVENL QAVSTSPTSI LITWEPPAYA
561NGPVQG YRL FCTEVSTGKE QNIEVDGLSY KLEGLKKFTE
601YSLRFLAYNR YGPGVSTDDI TVVTLSDVPS APPQNVSLEV
641VNSRSIK VS WLPPPSGTQN GFITGYKIRH RKTTRRGEME
681TLEPNNLWYL FTGLEKGSQY SFQVSAMTVN GTGPPSNWYT
721AETPENDL D ESQVPDQPSS LHVRPQTNCI IMSWTPPLNP
761NIVVRGYIIG YGVGSPYAET VRVDSKQRYY SIERLESSSH
801YVISLKAFN NAGEGVPLYE SATTRSITDP TDPVDYYPLL
841DDFPTSVPDL STPMLPPVGV QAVALTHDAV RVSWADNSVP
881KNQKTSEVRL YTVRWRTSF SASAKYKSED TTSLSYTATG
921LKPNTMYEFS VMVTKNRRSS TWSMTAHATT YEAAPTSAPK
961DLTVITREGK P RAVIVSWQ PPLEANGKIT AYILFYTLDK
1001NIPIDDWIME TISGDRLTHQ IMDLNLDTMY YFRIQARNSK
1041GVGPLSDPIL FR TLKVEHP DKMANDQGRH GDGGYWPVDT
1081NLIDRSTLNE PPIGQMHPPH GSVTPQKNSN LLVIIVVTVG
1121VITVLVVVIV AVI CTRRSS AQQRKKRATH SAGKRKGSQK
1161DLRPPDLWIH HEEMEMKNIE KPSGTDPAGR DSPIQSCQDL
1201TPVSHSQSET QLGS KSTSH SGQDTEEAGS SMSTLERSLA
1241ARRAPRAKLM IPMDAQSNNP AVVSAIPVPT LESAQYPGIL
1281PSPTCGYPHP QFTLR PVPF PTLSVDRGFG AGRSQSVSEG
1321PTTQQPPMLP PSQPEHSSSE EAPSRTIPTA CVRPTHPLRS
1361FANPLLPPPM SAIEPK VPY TPLLSQPGPT LPKTHVKTAS
1401LGLAGKARSP LLPVSVPTAP EVSEESHKPT EDSANVYEQD
1441DLSEQMASLE GLMKQLN AI TGSAF
结构预测来自 AlphaFold DB（UniProt: P43146），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

基因突变

基因突变

DCC基因的碱基突变：           仅显示部分snp
rs714       rs2256       rs16920       rs168332       rs186984       rs238422       rs347534       rs347535       rs347536       rs347537       rs347538       rs347539       rs347540       rs347541       rs347542       rs347543       rs347544      

基因表达

基因表达

DCC基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
ATGTGAGGCATCTTTAGGAG
57
CTAGACTAAGTAGGACCTGCT
58
GGGACTTTACCAATGTGAGG
58
TTTCATTGCCCTGCTACTG
58
GACTTTACCAATGTGAGGCA
58
ATATTTGCTCCTGCTACTGC
58
AGTCTCTGGAAAGCCTGTG
59
TGCTTCCTCCCACTATCTG
58
CTCCTGAAGCTTGAAGTTCC
59
CCAGAGACTGTACATTCAAACTC
59
CCTGGGCAACATATAGACCA
59
TGAGTAGCACTGTGTCTCC
59
AGTCTCTGGAAAGCCTGTG
59
TGCTTCCTCCCACTATCTG
59
TCAGCCAATGTGTATGAACAG
59
GTGATGGCATTAAGCTGCT
59
CTTTGCTTCCTGTGTCTGTG
60
CTCCATCTCCACATTGGCT
60
TCAGCCAATGTGTATGAACAG
59
GTGATGGCATTAAGCTGCT
59

转录因子

转录因子

转录因子
影响基因
影响类型
参考文献链接（PubMed）
SOX9
DCC
Activation
19745029

基因本体信息

DCC基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

DCC基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0005042
E7EQM8 (UniProtKB)
IEA
GO:0006915
E7EQM8 (UniProtKB)
IEA
GO:0007411
E7EQM8 (UniProtKB)
IEA
GO:0016021
E7EQM8 (UniProtKB)
IEA
GO:0038007
E7EQM8 (UniProtKB)
IEA
GO:0005042
H0Y2Q5 (UniProtKB)
IEA
GO:0006915
H0Y2Q5 (UniProtKB)
IEA
GO:0007411
H0Y2Q5 (UniProtKB)
IEA
GO:0038007
H0Y2Q5 (UniProtKB)
IEA
GO:0005042
J3QKL2 (UniProtKB)
IEA
GO:0006915
J3QKL2 (UniProtKB)
IEA
GO:0007411
J3QKL2 (UniProtKB)
IEA
GO:0038007
J3QKL2 (UniProtKB)
IEA
GO:0005042
J3QLB0 (UniProtKB)
IEA
GO:0006915
J3QLB0 (UniProtKB)
IEA
GO:0007411
J3QLB0 (UniProtKB)
IEA
GO:0038007
J3QLB0 (UniProtKB)
IEA
GO:0005042
J3QLT8 (UniProtKB)
IEA
GO:0006915
J3QLT8 (UniProtKB)
IEA
GO:0007411
J3QLT8 (UniProtKB)
IEA
GO:0038007
J3QLT8 (UniProtKB)
IEA
GO:0005042
J3QQJ6 (UniProtKB)
IEA
GO:0006915
J3QQJ6 (UniProtKB)
IEA
GO:0007411
J3QQJ6 (UniProtKB)
IEA
GO:0038007
J3QQJ6 (UniProtKB)
IEA
GO:0005042
J3QRL3 (UniProtKB)
IEA
GO:0006915
J3QRL3 (UniProtKB)
IEA
GO:0007411
J3QRL3 (UniProtKB)
IEA
GO:0038007
J3QRL3 (UniProtKB)
IEA
GO:0005042
J3QRM6 (UniProtKB)
IEA
GO:0006915
J3QRM6 (UniProtKB)
IEA
GO:0007411
J3QRM6 (UniProtKB)
IEA
GO:0038007
J3QRM6 (UniProtKB)
IEA
GO:0005042
J3QS93 (UniProtKB)
IEA
GO:0006915
J3QS93 (UniProtKB)
IEA
GO:0007411
J3QS93 (UniProtKB)
IEA
GO:0016021
J3QS93 (UniProtKB)
IEA
GO:0038007
J3QS93 (UniProtKB)
IEA
GO:0001764
P43146 (UniProtKB)
IEA
GO:0004888
P43146 (UniProtKB)
TAS
GO:0005042
P43146 (UniProtKB)
IEA
GO:0005515
P43146 (UniProtKB)
IPI
GO:0005515
P43146 (UniProtKB)
IPI
GO:0005515
P43146 (UniProtKB)
IPI
GO:0005515
P43146 (UniProtKB)
IPI
GO:0005515
P43146 (UniProtKB)
IPI
GO:0005515
P43146 (UniProtKB)
IPI
GO:0005515
P43146 (UniProtKB)
IPI
GO:0005515
P43146 (UniProtKB)
IPI
GO:0005515
P43146 (UniProtKB)
IPI
GO:0005829
P43146 (UniProtKB)
TAS
GO:0005886
P43146 (UniProtKB)
TAS
GO:0005886
P43146 (UniProtKB)
TAS
GO:0005886
P43146 (UniProtKB)
TAS
GO:0005886
P43146 (UniProtKB)
TAS
GO:0005886
P43146 (UniProtKB)
TAS
GO:0005886
P43146 (UniProtKB)
TAS
GO:0005886
P43146 (UniProtKB)
TAS
GO:0005886
P43146 (UniProtKB)
TAS
GO:0005886
P43146 (UniProtKB)
TAS
GO:0005886
P43146 (UniProtKB)
TAS
GO:0005886
P43146 (UniProtKB)
TAS
GO:0005886
P43146 (UniProtKB)
TAS
GO:0005886
P43146 (UniProtKB)
TAS
GO:0005886
P43146 (UniProtKB)
TAS
GO:0005886
P43146 (UniProtKB)
TAS
GO:0005886
P43146 (UniProtKB)
TAS
GO:0005886
P43146 (UniProtKB)
TAS
GO:0006915
P43146 (UniProtKB)
TAS
GO:0007409
P43146 (UniProtKB)
TAS
GO:0007411
P43146 (UniProtKB)
TAS
GO:0010977
P43146 (UniProtKB)
TAS
GO:0016021
P43146 (UniProtKB)
IEA
GO:0021965
P43146 (UniProtKB)
IEA
GO:0030424
P43146 (UniProtKB)
IEA
GO:0033563
P43146 (UniProtKB)
IEA
GO:0033564
P43146 (UniProtKB)
IEA
GO:0038007
P43146 (UniProtKB)
IEA
GO:0048671
P43146 (UniProtKB)
TAS
GO:0097192
P43146 (UniProtKB)
TAS
GO:1901214
P43146 (UniProtKB)
IMP
GO:2000171
P43146 (UniProtKB)
TAS

基因相关microRNA

基因相关microRNA

可能调控 DCC基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

String
BioGrid
IntAct
mentha
MINT
Reactome
加载中…
关联基因 作用方式 资源库来源/分值

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
MIRROR MOVEMENTS 1 0.24 0 7 CLINVAR_CTD_human
Colorectal Neoplasms 0.12953026 9 2 BeFree_CTD_human_LHGDN
Colon Carcinoma 0.122442977 9 1 BeFree_CLINVAR
Malignant neoplasm of gallbladder 0.120542884 3 1 BeFree_GWASCAT
Obesity 0.12 1 1 GWASCAT
Eosinophilic esophagitis 0.12 1 1 GWASCAT
melanoma 0.12 1 0 CTD_human
Reperfusion Injury 0.08 1 0 RGD
Neuritis, Autoimmune, Experimental 0.08 1 0 RGD
Colorectal Cancer 0.014039032 44 2 BeFree_GAD

基因相关文献

基因相关文献

Soft robotic cardiac sleeves: materials, actuation mechanisms and translational pathways.
Foroughi J, Aloko S, Spinks G, Wu L, Wu S, Hayward C, Wang CH, Ruhparwar A Mater Horiz IF: 11.4 2026-06-12
Gait Alterations Due to DCC Gene Variants in Individuals with Congenital Mirror Movements.
Law NY, Desrosiers S, Sivanesan S, Tonkov H, Charron F, Bretzner F, Srour M, Barthélemy D Mov Disord Clin Pract IF: 3.4 2026-04-10
Differential chromatin looping regulated by two GA-binding transcription factors creates an X-specific chromatin environment for dosage compensation.
Aguilera J, Cortez K, Alonzo LCS, Aldana M, Aragon A, Gray C, Woodman-Sousa M, Grive KJ, Ray M, Larschan E bioRxiv 2026-03-14
Di-Chimeric Cell Therapy Derived From Hematopoietic and Mesenchymal Stem Cells Promotes Immune Tolerance and Extends Vascularized Composite Allograft Survival.
Siemionow M, Uygur SH, Stawarz K, Chambily L, Budzynska K, Radecka W Arch Immunol Ther Exp (Warsz) IF: 3.2 2026-01-01
Effectiveness of a pharmacist diabetes coaching program: A propensity-matched retrospective analysis.
Amante D, Malkani S, Haas R, Wang B, Barry C, McElnea B, Piz L, Pugliese G, Sharma H, Soni A PLoS One IF: 2.6 None

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基因相关服务

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