ERBB2 (erb-b2 receptor tyrosine kinase 2)

Gene Basic Information

Gene Basic Information

symbol
ERBB2
locus group
protein-coding gene
location
17q12
gene_family
Receptor Tyrosine Kinases|CD molecules|minor histocompatibility antigens
alias symbol
NEU|HER-2|CD340|HER2|c-ERB2|c-ERB-2|MLN-19|p185(erbB2)
alias name
neuro/glioblastoma derived oncogen…
entrez id
2064
ensembl gene id
ENSG00000141736
ucsc gene id
uc002hso.4
refseq accession
NM_004448
hgnc_id
HGNC:3430
approved reserved
2001-06-22

Chromosome Location

Chromosome Location

17q12

Gene Summary

Gene Summary

ChineseEnglish

ERBB2, also designated HER2 or NEU, encodes the human epidermal growth factor receptor 2, a critical transmembrane receptor tyrosine kinase that serves as a central coordinator of the ERBB signaling family, which includes ERBB1 (EGFR/HER1), ERBB3 (HER3), and ERBB4 (HER4). While ERBB2 lacks a known direct ligand-binding capability, it functions as a potent co-receptor that preferentially forms heterodimers with other ERBB family members, thereby triggering robust activation of downstream intracellular cascades such as the MAPK and PI3K-AKT pathways to drive essential cellular processes including proliferation, differentiation, and survival. Although expressed in various tissues, ERBB2 is frequently amplified or overexpressed in several malignancies, notably breast, gastric, and ovarian cancers, where it acts as a dominant oncogene; in approximately 20% of breast cancer cases, this overexpression correlates with aggressive tumor phenotypes, enhanced invasiveness, and poor clinical prognosis. The constitutive activation resulting from ERBB2 mutations or amplification leads to the upregulation of cell cycle regulators like Cyclin D1 and anti-apoptotic factors such as BCL-2, while also fostering resistance to chemotherapy and endocrine therapies through complex crosstalk with other signaling networks, including the estrogen receptor pathway. Consequently, while dysregulated ERBB2 expression is a major driver of tumorigenesis and metastasis, its physiological role in tissue homeostasis is equally vital, as evidenced by the cardiac toxicity observed when therapeutic agents such as trastuzumab and pertuzumab inhibit its activity, underscoring the delicate balance between its oncogenic potential and its necessity for normal physiological functions, particularly in maintaining cardiac integrity.

OMIM entry for ERBB2     Wikipedia entry for ERBB2

Gene Sequence

Gene Sequence

Nucleotide sequence of ERBB2:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MELAALCRWG LLLALLPPGA ASTQVCTGTD MKLRLPASPE
41THLDMLRHLY QGCQVVQGNL ELTYLPTNAS LSFLQDIQEV
81 QGYVLIAHN QVRQVPLQRL RIVRGTQLFE DNYALAVLDN
121GDPLNNTTPV TGASPGGLRE LQLRSLTEIL KGGVLIQRNP
161Q LCYQDTIL WKDIFHKNNQ LALTLIDTNR SRACHPCSPM
201CKGSRCWGES SEDCQSLTRT VCAGGCARCK GPLPTDCCHE
241QC AAGCTGP KHSDCLACLH FNHSGICELH CPALVTYNTD
281TFESMPNPEG RYTFGASCVT ACPYNYLSTD VGSCTLVCPL
321HNQ EVTAED GTQRCEKCSK PCARVCYGLG MEHLREVRAV
361TSANIQEFAG CKKIFGSLAF LPESFDGDPA SNTAPLQPEQ
401LQVF ETLEE ITGYLYISAW PDSLPDLSVF QNLQVIRGRI
441LHNGAYSLTL QGLGISWLGL RSLRELGSGL ALIHHNTHLC
481FVHTV PWDQ LFRNPHQALL HTANRPEDEC VGEGLACHQL
521CARGHCWGPG PTQCVNCSQF LRGQECVEEC RVLQGLPREY
561VNARHC LPC HPECQPQNGS VTCFGPEADQ CVACAHYKDP
601PFCVARCPSG VKPDLSYMPI WKFPDEEGAC QPCPINCTHS
641CVDLDDK GC PAEQRASPLT SIISAVVGIL LVVVLGVVFG
681ILIKRRQQKI RKYTMRRLLQ ETELVEPLTP SGAMPNQAQM
721RILKETEL R KVKVLGSGAF GTVYKGIWIP DGENVKIPVA
761IKVLRENTSP KANKEILDEA YVMAGVGSPY VSRLLGICLT
801STVQLVTQL MPYGCLLDHV RENRGRLGSQ DLLNWCMQIA
841KGMSYLEDVR LVHRDLAARN VLVKSPNHVK ITDFGLARLL
881DIDETEYHAD GGKVPIKWM ALESILRRRF THQSDVWSYG
921VTVWELMTFG AKPYDGIPAR EIPDLLEKGE RLPQPPICTI
961DVYMIMVKCW M IDSECRPR FRELVSEFSR MARDPQRFVV
1001IQNEDLGPAS PLDSTFYRSL LEDDDMGDLV DAEEYLVPQQ
1041GFFCPDPAPG AG GMVHHRH RSSSTRSGGG DLTLGLEPSE
1081EEAPRSPLAP SEGAGSDVFD GDLGMGAAKG LQSLPTHDPS
1121PLQRYSEDPT VPL PSETDG YVAPLTCSPQ PEYVNQPDVR
1161PQPPSPREGP LPAARPAGAT LERPKTLSPG KNGVVKDVFA
1201FGGAVENPEY LTPQ GGAAP QPHPPPAFSP AFDNLYYWDQ
1241DPPERGAPPS TFKGTPTAEN PEYLGLDVPV
Structure predicted by AlphaFold DB(UniProt: P04626). Color indicates pLDDT confidence (dark blue = high, yellow/orange = low).

Gene Variants

Gene Variants

SNP variants of ERBB2:           Showing partial SNPs
rs169244       rs272159       rs903506       rs1058808       rs1136201       rs1565923       rs1801201       rs1810132       rs2088126       rs2132141       rs2230698       rs2230700       rs2313170       rs2517951       rs2517954       rs2517955       rs2517956      

Gene Expression

Gene Expression

Tissue expression of ERBB2:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
GAAGTTTCCAGATGAGGAGG
58
TTGTCATCCAGGTCCACAC
60
TTCCTGCAGGATATCCAGG
59
GTTGTCCTCAAAGAGCTGG
59
GTGCTAGACAATGGAGACC
58
TCAAGATCTCTGTGAGGCT
58
CTACAGCGGTACAGTGAGG
60
GGTTCACATATTCAGGCTGG
59
AATCTTAGACGAAGCATACGTG
59
ATAAGCTGTGTCACCAGCT
59
GAAGATCCGGAAGTACACGA
59
CCTTCACCTTCCTCAGCTC
60
AATATCCAGGAGTTTGCTGG
58
GAGTGAGACTCCATCAAAGC
58
AATCTTAGACGAAGCATACGTG
59
ATAAGCTGTGTCACCAGCT
59
AGAATGGCTCAGTGACCTG
59
GGGTCCTTATAGTGGGCAC
60
AACCTGGAACTCACCTACC
59
CTGGATATCCTGTAAACAGAGG
58

Transcription Factors

Transcription Factors

Transcription Factors
Target Gene
Interaction Type
PubMed References
AR
ERBB2
Activation
21613411
AR
ERBB2
Unknown
21741601
ATF1
ERBB2
Unknown
10698518
ATF7
ERBB2
Unknown
10698518
CREB1
ERBB2
Unknown
10698518
DENND4A
ERBB2
Repression
23421821
ELF1
ERBB2
Unknown
7914192
ELK1
ERBB2
Unknown
7914192
EP300
ERBB2
Unknown
9045619
ETV4
ERBB2
Repression
10655108; 15235125; 16632435; 17168666

Gene Ontology

Subcellular localization of ERBB2 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for ERBB2:

GO ID
Protein
Source DB
GO:0004714
B4DTR1 (UniProtKB)
IEA
GO:0005524
B4DTR1 (UniProtKB)
IEA
GO:0005634
B4DTR1 (UniProtKB)
IDA
GO:0005737
B4DTR1 (UniProtKB)
IDA
GO:0005886
B4DTR1 (UniProtKB)
IDA
GO:0016021
B4DTR1 (UniProtKB)
IEA
GO:0018108
B4DTR1 (UniProtKB)
IEA
GO:0018108
B4DTR1 (UniProtKB)
IEA
GO:0004714
F5H1T4 (UniProtKB)
IEA
GO:0005524
F5H1T4 (UniProtKB)
IEA
GO:0007169
F5H1T4 (UniProtKB)
IEA
GO:0016020
F5H1T4 (UniProtKB)
IEA
GO:0018108
F5H1T4 (UniProtKB)
IEA
GO:0004713
J3KTI5 (UniProtKB)
IEA
GO:0005524
J3KTI5 (UniProtKB)
IEA
GO:0016021
J3KTI5 (UniProtKB)
IEA
GO:0018108
J3KTI5 (UniProtKB)
IEA
GO:0004714
J3QLU9 (UniProtKB)
IEA
GO:0004716
J3QLU9 (UniProtKB)
IEA
GO:0005524
J3QLU9 (UniProtKB)
IEA
GO:0007169
J3QLU9 (UniProtKB)
IEA
GO:0016021
J3QLU9 (UniProtKB)
IEA
GO:0018108
J3QLU9 (UniProtKB)
IEA
GO:0018108
J3QLU9 (UniProtKB)
IEA
GO:0023014
J3QLU9 (UniProtKB)
IEA
GO:0016021
J3QRJ7 (UniProtKB)
IEA
GO:0004714
J3QRX1 (UniProtKB)
IEA
GO:0005524
J3QRX1 (UniProtKB)
IEA
GO:0007169
J3QRX1 (UniProtKB)
IEA
GO:0016020
J3QRX1 (UniProtKB)
IEA
GO:0018108
J3QRX1 (UniProtKB)
IEA
GO:0000165
P04626 (UniProtKB)
TAS
GO:0001042
P04626 (UniProtKB)
IDA
GO:0001934
P04626 (UniProtKB)
ISS
GO:0004713
P04626 (UniProtKB)
IDA
GO:0004713
P04626 (UniProtKB)
IGI
GO:0004713
P04626 (UniProtKB)
TAS
GO:0004713
P04626 (UniProtKB)
TAS
GO:0004713
P04626 (UniProtKB)
TAS
GO:0004714
P04626 (UniProtKB)
IDA
GO:0004716
P04626 (UniProtKB)
IEA
GO:0004888
P04626 (UniProtKB)
IDA
GO:0005088
P04626 (UniProtKB)
TAS
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005515
P04626 (UniProtKB)
IPI
GO:0005524
P04626 (UniProtKB)
IEA
GO:0005634
P04626 (UniProtKB)
IDA
GO:0005634
P04626 (UniProtKB)
IDA
GO:0005634
P04626 (UniProtKB)
IDA
GO:0005737
P04626 (UniProtKB)
IDA
GO:0005886
P04626 (UniProtKB)
IDA
GO:0005886
P04626 (UniProtKB)
NAS
GO:0005886
P04626 (UniProtKB)
IDA
GO:0005886
P04626 (UniProtKB)
TAS
GO:0005886
P04626 (UniProtKB)
TAS
GO:0005886
P04626 (UniProtKB)
TAS
GO:0005886
P04626 (UniProtKB)
TAS
GO:0005886
P04626 (UniProtKB)
TAS
GO:0005886
P04626 (UniProtKB)
TAS
GO:0005886
P04626 (UniProtKB)
TAS
GO:0005886
P04626 (UniProtKB)
TAS
GO:0005886
P04626 (UniProtKB)
TAS
GO:0005886
P04626 (UniProtKB)
TAS
GO:0005886
P04626 (UniProtKB)
TAS
GO:0005886
P04626 (UniProtKB)
TAS
GO:0005886
P04626 (UniProtKB)
TAS
GO:0005886
P04626 (UniProtKB)
TAS
GO:0005886
P04626 (UniProtKB)
TAS
GO:0005886
P04626 (UniProtKB)
TAS
GO:0005886
P04626 (UniProtKB)
TAS
GO:0005886
P04626 (UniProtKB)
TAS
GO:0005886
P04626 (UniProtKB)
TAS
GO:0005886
P04626 (UniProtKB)
TAS
GO:0005886
P04626 (UniProtKB)
TAS
GO:0005886
P04626 (UniProtKB)
TAS
GO:0005886
P04626 (UniProtKB)
TAS
GO:0005886
P04626 (UniProtKB)
TAS
GO:0005886
P04626 (UniProtKB)
TAS
GO:0005886
P04626 (UniProtKB)
TAS
GO:0005886
P04626 (UniProtKB)
TAS
GO:0005886
P04626 (UniProtKB)
TAS
GO:0005886
P04626 (UniProtKB)
TAS
GO:0005886
P04626 (UniProtKB)
TAS
GO:0005886
P04626 (UniProtKB)
TAS
GO:0005886
P04626 (UniProtKB)
TAS
GO:0005886
P04626 (UniProtKB)
TAS
GO:0005886
P04626 (UniProtKB)
TAS
GO:0005886
P04626 (UniProtKB)
TAS
GO:0005886
P04626 (UniProtKB)
TAS
GO:0005886
P04626 (UniProtKB)
TAS
GO:0006351
P04626 (UniProtKB)
IEA
GO:0006468
P04626 (UniProtKB)
TAS
GO:0007165
P04626 (UniProtKB)
IDA
GO:0007166
P04626 (UniProtKB)
IDA
GO:0007167
P04626 (UniProtKB)
TAS
GO:0007169
P04626 (UniProtKB)
IDA
GO:0007169
P04626 (UniProtKB)
TAS
GO:0007422
P04626 (UniProtKB)
IEA
GO:0007507
P04626 (UniProtKB)
IEA
GO:0007528
P04626 (UniProtKB)
IEA
GO:0008022
P04626 (UniProtKB)
IPI
GO:0008022
P04626 (UniProtKB)
IPI
GO:0008045
P04626 (UniProtKB)
IEA
GO:0008283
P04626 (UniProtKB)
TAS
GO:0010008
P04626 (UniProtKB)
IDA
GO:0014065
P04626 (UniProtKB)
IDA
GO:0014066
P04626 (UniProtKB)
TAS
GO:0016021
P04626 (UniProtKB)
NAS
GO:0016323
P04626 (UniProtKB)
IDA
GO:0016324
P04626 (UniProtKB)
IEA
GO:0018108
P04626 (UniProtKB)
IEA
GO:0018108
P04626 (UniProtKB)
IEA
GO:0019903
P04626 (UniProtKB)
IPI
GO:0030307
P04626 (UniProtKB)
IMP
GO:0031410
P04626 (UniProtKB)
IEA
GO:0032886
P04626 (UniProtKB)
IDA
GO:0033088
P04626 (UniProtKB)
IEA
GO:0038128
P04626 (UniProtKB)
TAS
GO:0042060
P04626 (UniProtKB)
IDA
GO:0042552
P04626 (UniProtKB)
IEA
GO:0042802
P04626 (UniProtKB)
IPI
GO:0042802
P04626 (UniProtKB)
IPI
GO:0042802
P04626 (UniProtKB)
IPI
GO:0042802
P04626 (UniProtKB)
IPI
GO:0042802
P04626 (UniProtKB)
IPI
GO:0043125
P04626 (UniProtKB)
TAS
GO:0043209
P04626 (UniProtKB)
IEA
GO:0043235
P04626 (UniProtKB)
IDA
GO:0043235
P04626 (UniProtKB)
IDA
GO:0043235
P04626 (UniProtKB)
TAS
GO:0043406
P04626 (UniProtKB)
IDA
GO:0043547
P04626 (UniProtKB)
ISS
GO:0045727
P04626 (UniProtKB)
IMP
GO:0045765
P04626 (UniProtKB)
NAS
GO:0045785
P04626 (UniProtKB)
IDA
GO:0045943
P04626 (UniProtKB)
IMP
GO:0045945
P04626 (UniProtKB)
IDA
GO:0046777
P04626 (UniProtKB)
IDA
GO:0046854
P04626 (UniProtKB)
IEA
GO:0046934
P04626 (UniProtKB)
TAS
GO:0046982
P04626 (UniProtKB)
IDA
GO:0046982
P04626 (UniProtKB)
IPI
GO:0046983
P04626 (UniProtKB)
NAS
GO:0048015
P04626 (UniProtKB)
TAS
GO:0048471
P04626 (UniProtKB)
IEA
GO:0048709
P04626 (UniProtKB)
IEA
GO:0050679
P04626 (UniProtKB)
IDA
GO:0070372
P04626 (UniProtKB)
IMP
GO:0071363
P04626 (UniProtKB)
IDA
GO:0090314
P04626 (UniProtKB)
IDA
GO:2000145
P04626 (UniProtKB)
TAS
GO:0019838
P04626 (UniProtKB)
IDA

Related microRNA

Related microRNA

microRNAs potentially regulating ERBB2:     

Gene Interactions

Gene Interactions

String
BioGrid
IntAct
mentha
MINT
Reactome
Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Neoplasm Metastasis 0.331048018 371 0 BeFree_CTD_human_GAD_LHGDN_RGD
Mammary Neoplasms 0.289468128 538 0 BeFree_CTD_human_GAD_LHGDN
ovarian neoplasm 0.279458387 56 1 BeFree_CLINVAR_CTD_human_LHGDN
Stomach Neoplasms 0.263152011 16 1 BeFree_CLINVAR_CTD_human_LHGDN
Malignant neoplasm of breast 0.24 2853 22 BeFree_GAD_MGD
Adenocarcinoma 0.213796419 211 0 BeFree_CTD_human_LHGDN
Mammary Neoplasms, Experimental 0.2 3 0 CTD_human_RGD
Carcinogenesis 0.168859537 181 2 BeFree_CTD_human
Prostatic Neoplasms 0.153496597 25 0 BeFree_CTD_human_LHGDN
Lung Neoplasms 0.153496597 24 0 BeFree_CTD_human_LHGDN

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Rana D, Kaur B, Bhardwaj N, Goyal H, Sharma R, Saini U, Chouhan DK, Verma I, Sharma S, Kaur J Int J Biol Macromol IF: 8.7 2026-02-00
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Cayol F, Macharashvili I, Barochiner J, Dominguez MP, Menna E, Perez Mesa PJ, Pandolfi J, Carranza O, Sanchez R, Marchioni A, Gueron G, Pena L, Cerini M, Cutuli H, Rivello HG, Taetti G, Camacho AF JCO Glob Oncol 2026-08-00
Transcriptomic Analysis Reveals Novel Mechanisms Underlying Neutrophil Activation Induced by High Salt.
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