ETS1 (ETS proto-oncogene 1, transcription factor)

基因基本信息

基因基本信息

symbol:
ETS1
locus group:
protein-coding gene
location:
11q24.3
gene_family:
Helix-turn-helix ETS type domain containing
alias symbol:
FLJ10768|ETS-1
alias name:
Avian erythroblastosis virus E26...
entrez id:
2113
ensembl gene id:
ENSG00000134954
ucsc gene id:
uc010sbs.2
refseq accession:
NM_005238
hgnc_id:
HGNC:3488
approved reserved:
1986-01-01

基因染色体位置

基因染色体位置

11q24.3

基因简述

基因简述

ETS1（E26 transformation-specific 1）是一种重要的转录因子，属于ETS基因家族。该家族的特点是拥有一个高度保守的约85个氨基酸的ETS结构域，能够识别并结合特定的DNA序列（通常含有GGA核心基序），从而调控下游靶基因的表达。ETS家族成员广泛参与细胞增殖、分化、凋亡、血管生成和免疫调节等生物学过程。ETS1在多种细胞类型中表达，包括淋巴细胞、内皮细胞和成纤维细胞，其功能涉及免疫系统发育、血管形成和炎症反应。ETS1通过调控细胞周期相关基因（如Cyclin D1）和凋亡相关基因（如Bcl-2）的表达来影响细胞命运。突变或异常表达可能导致功能失调，例如ETS1的某些突变会削弱其DNA结合能力，导致转录调控异常，与自身免疫性疾病（如系统性红斑狼疮）和某些癌症（如白血病、乳腺癌）的发生发展相关。当ETS1过表达时，可能促进细胞增殖、迁移和侵袭，增加肿瘤恶性程度；而降低表达可能导致免疫细胞功能缺陷或血管发育异常。ETS1与其他ETS家族成员（如ETS2、ERG）功能部分重叠，但各自也有独特的作用靶点和调控网络。该基因的异常表达还可能影响其他信号通路（如MAPK/ERK和PI3K/AKT）的活性，进一步放大其对细胞行为的调控效应。研究ETS1有助于理解相关疾病的分子机制，并为开发靶向治疗策略提供潜在方向。

中文English

该基因编码的ETS转录因子家族，其通过识别该核心共有DNA序列GGAA / T的靶基因的保守的ETS DNA结合结构域的存在所定义的成员。这些蛋白质的功能或作为转录激活因子或多种基因的阻抑，和涉及干细胞发育，细胞衰老和死亡，肿瘤发生。另外剪接转录变体编码不同的亚型已经为这??个基因描述。[由RefSeq的，2011年7月提供]

OMIM数据库中对ETS1基因的介绍     Wikipedia数据库中对ETS1基因的介绍

基因序列

基因序列

ETS1基因的碱基序列：[NCBI]
Loading Gene Browser...

编码蛋白质

编码蛋白质

蛋白质序列
1MKAAVDLKPT LTIIKTEKVD LELFPSPDME CADVPLLTPS
41SKEMMSQALK ATFSGFTKEQ QRLGIPKDPR QWTETHVRDW
81 VMWAVNEFS LKGVDFQKFC MNGAALCALG KDCFLELAPD
121FVGDILWEHL EILQKEDVKP YQVNGVNPAY PESRYTSDYF
161I SYGIEHAQ CVPPSEFSEP SFITESYQTL HPISSEELLS
201LKYENDYPSV ILRDPLQTDT LQNDYFAIKQ EVVTPDNMCM
241GR TSRGKLG GQDSFESIES YDSCDRLTQS WSSQSSFNSL
281QRVPSYDSFD SEDYPAALPN HKPKGTFKDY VRDRADLNKD
321KPV IPAAAL AGYTGSGPIQ LWQFLLELLT DKSCQSFISW
361TGDGWEFKLS DPDEVARRWG KRKNKPKMNY EKLSRGLRYY
401YDKN IIHKT AGKRYVYRFV CDLQSLLGYT PEELHAMLDV
441KPDADE
结构预测来自 AlphaFold DB（UniProt: P14921），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

基因突变

基因突变

ETS1基因的碱基突变：           仅显示部分snp
rs8705       rs879258       rs950605       rs1122832       rs1128334       rs1128355       rs1317489       rs1944850       rs1944854       rs2156696       rs2230004       rs2230005       rs2269458       rs3802826       rs3809006       rs3832740       rs3924289      

基因表达

基因表达

ETS1基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
CAGCAAAGACCTTGCTACC
59
GCACATTCCATATCTGAGACAC
59
GCAGAAAGAGGATGTGAAACC
60
AAGTAATCCGAGGTATAGCGG
59
CTTGCAGAATGACTACTTTGCT
59
CGAGTTTACCACGACTGGT
60
GCTACTTTGTGGATTCTGCTG
60
ATCTGTCCGTATTTCACACCA
60
CTTGCAGAATGACTACTTTGCT
59
CGAGTTTACCACGACTGGT
60
ATATCCCTGATATGGAATGTGC
58
TGAAACCACTGAAAGTAGCT
57
TGTCTCAGAATTACAAGGCCA
60
CCGTGTTGACAGTTCATGTC
60
GTAAGTGAGGTGCTGAGAG
57
TCATAAGTGTTGCTAGGTCC
57
GACAAGCCTGTCATTCCTG
59
ATAGCTGGATTGGTCCACTG
60
TTTCTGACCCAGATGAGGTG
60
AATAGTAGCGTAGGCCACG
59

转录因子

转录因子

转录因子
影响基因
影响类型
参考文献链接（PubMed）
ETS1
ABCB1
Activation
20392592
ETS1
ANGPT2
Activation
15003510
ETS1
ANPEP
Activation
14507917
ETS1
ATXN2
Unknown
22914732
ETS1
BAX
Repression
17213822
ETS1
BMP4
Activation
15695386
ETS1
EMSY
Unknown
24582497
ETS1
CA9
Repression
18381358
ETS1
CASP1
Activation
16103071
ETS1
CD6
Unknown
19446338

基因本体信息

ETS1基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

ETS1基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0000981
P14921 (UniProtKB)
IBA
GO:0000982
P14921 (UniProtKB)
IDA
GO:0001666
P14921 (UniProtKB)
IEA
GO:0003677
P14921 (UniProtKB)
ISS
GO:0003700
P14921 (UniProtKB)
IDA
GO:0003700
P14921 (UniProtKB)
IDA
GO:0003700
P14921 (UniProtKB)
IDA
GO:0003700
P14921 (UniProtKB)
IDA
GO:0005515
P14921 (UniProtKB)
IPI
GO:0005515
P14921 (UniProtKB)
IPI
GO:0005515
P14921 (UniProtKB)
IPI
GO:0005515
P14921 (UniProtKB)
IPI
GO:0005515
P14921 (UniProtKB)
IPI
GO:0005515
P14921 (UniProtKB)
IPI
GO:0005515
P14921 (UniProtKB)
IPI
GO:0005515
P14921 (UniProtKB)
IPI
GO:0005515
P14921 (UniProtKB)
IPI
GO:0005515
P14921 (UniProtKB)
IPI
GO:0005515
P14921 (UniProtKB)
IPI
GO:0005515
P14921 (UniProtKB)
IPI
GO:0005515
P14921 (UniProtKB)
IPI
GO:0005515
P14921 (UniProtKB)
IPI
GO:0005515
P14921 (UniProtKB)
IPI
GO:0005515
P14921 (UniProtKB)
IPI
GO:0005515
P14921 (UniProtKB)
IPI
GO:0005515
P14921 (UniProtKB)
IPI
GO:0005515
P14921 (UniProtKB)
IPI
GO:0005515
P14921 (UniProtKB)
IPI
GO:0005515
P14921 (UniProtKB)
IPI
GO:0005515
P14921 (UniProtKB)
IPI
GO:0005515
P14921 (UniProtKB)
IPI
GO:0005515
P14921 (UniProtKB)
IPI
GO:0005515
P14921 (UniProtKB)
IPI
GO:0005634
P14921 (UniProtKB)
IMP
GO:0005634
P14921 (UniProtKB)
IDA
GO:0005634
P14921 (UniProtKB)
IDA
GO:0005634
P14921 (UniProtKB)
IMP
GO:0005654
P14921 (UniProtKB)
IDA
GO:0005654
P14921 (UniProtKB)
TAS
GO:0005654
P14921 (UniProtKB)
TAS
GO:0005667
P14921 (UniProtKB)
IEA
GO:0005737
P14921 (UniProtKB)
IEA
GO:0006366
P14921 (UniProtKB)
IDA
GO:0006955
P14921 (UniProtKB)
TAS
GO:0007565
P14921 (UniProtKB)
IEA
GO:0008134
P14921 (UniProtKB)
NAS
GO:0008284
P14921 (UniProtKB)
IEA
GO:0008285
P14921 (UniProtKB)
TAS
GO:0009612
P14921 (UniProtKB)
IEA
GO:0010595
P14921 (UniProtKB)
IMP
GO:0010715
P14921 (UniProtKB)
IEA
GO:0021854
P14921 (UniProtKB)
IEA
GO:0021983
P14921 (UniProtKB)
IEA
GO:0030578
P14921 (UniProtKB)
IDA
GO:0030578
P14921 (UniProtKB)
IDA
GO:0032355
P14921 (UniProtKB)
IEA
GO:0034616
P14921 (UniProtKB)
IEA
GO:0035035
P14921 (UniProtKB)
IEA
GO:0042802
P14921 (UniProtKB)
IPI
GO:0042981
P14921 (UniProtKB)
IDA
GO:0043565
P14921 (UniProtKB)
IEA
GO:0043565
P14921 (UniProtKB)
IEA
GO:0044849
P14921 (UniProtKB)
IEA
GO:0045648
P14921 (UniProtKB)
IDA
GO:0045765
P14921 (UniProtKB)
IMP
GO:0045766
P14921 (UniProtKB)
IEA
GO:0045786
P14921 (UniProtKB)
IMP
GO:0045786
P14921 (UniProtKB)
IDA
GO:0045893
P14921 (UniProtKB)
IDA
GO:0045893
P14921 (UniProtKB)
IDA
GO:0045893
P14921 (UniProtKB)
IDA
GO:0045944
P14921 (UniProtKB)
IDA
GO:0046677
P14921 (UniProtKB)
IDA
GO:0048870
P14921 (UniProtKB)
IMP
GO:0050728
P14921 (UniProtKB)
IEA
GO:0050729
P14921 (UniProtKB)
IDA
GO:0051272
P14921 (UniProtKB)
IMP
GO:0060055
P14921 (UniProtKB)
IEA
GO:0061614
P14921 (UniProtKB)
IDA
GO:0070301
P14921 (UniProtKB)
IEA
GO:0070555
P14921 (UniProtKB)
IEA
GO:1904996
P14921 (UniProtKB)
IMP
GO:0005634
V9GYD6 (UniProtKB)
IEA
GO:0043565
V9GYD6 (UniProtKB)
IEA

基因相关microRNA

基因相关microRNA

可能调控 ETS1基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

String
BioGrid
IntAct
mentha
MINT
Reactome
加载中…
关联基因 作用方式 资源库来源/分值

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Lupus Erythematosus, Systemic 0.253539756 16 2 BeFree_CTD_human_GAD_GWASCAT
Celiac Disease 0.242367032 1 1 CTD_human_GAD_GWASCAT
Reperfusion Injury 0.12 1 0 CTD_human
Diabetes Mellitus, Experimental 0.08 1 0 RGD
Mouth Neoplasms 0.08 1 0 RGD
Mammary Neoplasms 0.019613335 9 0 BeFree_LHGDN
melanoma 0.010616028 10 0 BeFree_LHGDN
ovarian neoplasm 0.005991584 4 0 BeFree_LHGDN
Prostatic Neoplasms 0.005720142 3 0 BeFree_LHGDN
Breast Carcinoma 0.00434307 16 0 BeFree

基因相关文献

基因相关文献

Modulation of PKCα/ETS1 by klotho restores CYB5R4-dependent mitochondrial function in proximal tubular epithelial cells to attenuate the progression of diabetic kidney disease.
Gan C, Zhou X, Qiu L, Chen D, Shi Y, Yang Q, Jiang H, Xiao H, Chen W, Yang X, Chen Y, Wang M, Yang H, Jiang W, Li Q Cardiovasc Diabetol IF: 4.752 2026-03-28
Fusobacterium nucleatum drives colorectal cancer progression through the circPTBP3/miR-760/PUM1 axis.
Li C, Liu Q, Shen H, Zou T, Fu L, Chen Y Oncogene IF: 9.1 2026-05-00
Integrated ATAC-seq and mRNA-seq analyses on granulosa cells identify key regulators of follicle selection in chickens.
Li D, Qi C, Sun Y, Kang L, Wei Q, Jiang Y J Anim Sci Biotechnol IF: 7.9 2026-04-17
CX3CR1 identifies a potent effector CD8+ T cell subset associated with anti-PD-1 therapeutic efficacy in colorectal cancer.
Ma J, Wu Y, Chen R, Wang N, Liu Y, Chen L, Wu S, Zheng X Front Immunol IF: 7.0 None
Di-2-ethylhexylphthalate-induced miR155-5P promotes placental ferroptosis.
Gu X, Sun F, Li Y, Yang S, Li Y Int J Biol Macromol IF: 8.7 2026-05-00
Transcriptomic profiling of chlorogenic acid and taurine treatment in human skin cells provides insights into cellular senescence mechanisms.
Kim B, Shin JG, Hong IS, Ahn Y, Seo JY, Shin JY, Lee S, Jun SH, Jeong ET, Jo H, Park MS, Kim DS, Kang NG, Kim Y, Won HH Front Mol Biosci None
Ets1-dependent Mek-Erk signaling drives adipose tissue macrophage anti-inflammatory polarization to ameliorates insulin resistance.
Song J, Ni J, Xie K, Cao J, Guo W, Zhao L, Chang X, Lu Y, Sun P, Yu J, Qiu C, Yang S, Liu W, Han X, Li K Cell Rep IF: 6.9 2026-04-07
Gene expression and metadata based identification of key genes for lung cancer, COPD, and IPF using machine learning and statistical models.
Yasmin MF, Hosen MF, Basar MA, Rahman A, Hasan M, Al Farid F, Karim HA, Miah ASM PLoS One IF: 2.6 None

基因相关服务

基因相关服务

基因相关评论

基因相关评论

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