FAIM (Fas apoptotic inhibitory molecule)
- symbol:
- FAIM
- locus group:
- protein-coding gene
- location:
- 3q22.3
- gene_family:
- alias symbol:
- FLJ10582|FAIM1
- alias name:
- None
- entrez id:
- 55179
- ensembl gene id:
- ENSG00000158234
- ucsc gene id:
- uc003esr.4
- refseq accession:
- NM_001033032
- hgnc_id:
- HGNC:18703
- approved reserved:
- 2002-05-29
FAIM（Fas Apoptotic Inhibitory Molecule）是一种抗凋亡蛋白，主要功能是抑制Fas受体介导的细胞凋亡途径。它通过干扰Fas信号通路的激活，阻止caspase-8的活化，从而保护细胞免受凋亡的影响。FAIM在多种组织中表达，尤其在神经系统中表达较高，可能参与神经细胞的存活调控。FAIM有两种主要亚型：FAIM-S（短型）和FAIM-L（长型），其中FAIM-L在神经元中富集，对神经保护作用更为显著。突变或表达异常可能导致细胞凋亡失调，与神经退行性疾病（如阿尔茨海默病）或自身免疫疾病相关。FAIM过表达可能增强细胞对凋亡的抵抗，但过度抑制凋亡可能促进肿瘤发生；而FAIM表达降低则可能增加细胞对凋亡的敏感性，导致组织损伤或神经退化。FAIM属于凋亡调控蛋白家族，该家族成员通常通过干扰死亡受体信号通路来调节细胞存活。目前对FAIM的研究仍在深入，其在疾病中的作用机制有待进一步阐明。
The protein encoded by this gene protects against death receptor-triggered apoptosis and regulates B-cell signaling and differentiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
Gene Ontology
Subcellular localization of FAIM (and its protein):
- plasma membrane
- cytoplasm
- extracellular
- golgi
- vesicle
- cytoskeleton
- endoplasmic reticulum
- nucleus
- endosome
- lysosome
- mitochondrion
Gene Ontology (GO) terms for FAIM:
| Interacting Gene | Interaction | Source/Score |
| Disease | Score | NofPmids | NofSnps | Source |
| Neoplasm Metastasis | 0.000271442 | 1 | 0 | BeFree |
| Nasopharyngeal carcinoma | 0.000271442 | 1 | 0 | BeFree |
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