FAIM2 (Fas apoptotic inhibitory molecule 2)

基因基本信息

基因基本信息

symbol:
FAIM2
locus group:
protein-coding gene
location:
12q13.12
gene_family:
alias symbol:
KIAA0950|LFG|NMP35|LIFEGUARD|TMBIM2|LFG2
alias name:
transmembrane BAX inhibitor moti...
entrez id:
23017
ensembl gene id:
ENSG00000135472
ucsc gene id:
uc001rvj.3
refseq accession:
NM_012306
hgnc_id:
HGNC:17067
approved reserved:
2002-10-08

基因染色体位置

基因染色体位置

12q13.12

基因简述

基因简述

FAIM2（Fas Apoptotic Inhibitory Molecule 2）是一种抗凋亡蛋白，属于FAIM基因家族，该家族还包括FAIM1。FAIM家族成员的主要共性是能够抑制Fas（一种死亡受体）介导的细胞凋亡（程序性细胞死亡），从而保护细胞免于过早死亡。FAIM2主要在神经系统中高表达，尤其在发育中的神经元和成熟神经元中，其表达产物通过干扰Fas信号通路中的关键步骤（如阻止Fas与FADD的相互作用）来阻断凋亡信号的传递。FAIM2的突变可能导致其抗凋亡功能丧失，增加神经元对凋亡刺激的敏感性，这与神经退行性疾病（如阿尔茨海默病）的发生可能相关。过表达FAIM2会增强细胞对凋亡的抵抗，可能用于治疗神经损伤或退行性疾病，但过度抑制凋亡也可能导致癌细胞存活。相反，FAIM2表达降低会使神经元更易凋亡，可能加速神经退行性病变。FAIM2还参与调节B细胞存活和免疫反应，其异常表达可能与自身免疫疾病有关。FAIM家族蛋白均含有保守的死亡效应结构域（DED-like domain），但FAIM2比FAIM1具有更强的抗凋亡活性，尤其在神经系统中作用更为突出。目前对FAIM2的研究仍在深入，其在神经保护、免疫调节和癌症中的潜在作用值得进一步探索。

中文English

无

OMIM数据库中对FAIM2基因的介绍     Wikipedia数据库中对FAIM2基因的介绍

基因序列

基因序列

FAIM2基因的碱基序列：[NCBI]
Loading Gene Browser...

编码蛋白质

编码蛋白质

蛋白质序列
1MTQGKLSVAN KAPGTEGQQQ VHGEKKEAPA VPSAPPSYEE
41ATSGEGMKAG AFPPAPTAVP LHPSWAYVDP SSSSSYDNGF
81 PTGDHELFT TFSWDDQKVR RVFVRKVYTI LLIQLLVTLA
121VVALFTFCDP VKDYVQANPG WYWASYAVFF ATYLTLACCS
161G PRRHFPWN LILLTVFTLS MAYLTGMLSS YYNTTSVLLC
201LGITALVCLS VTVFSFQTKF DFTSCQGVLF VLLMTLFFSG
241LI LAILLPF QYVPWLHAVY AALGAGVFTL FLALDTQLLM
281GNRRHSLSPE EYIFGALNIY LDIIYIFTFF LQLFGTNRE
结构预测来自 AlphaFold DB（UniProt: Q9BWQ8），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

基因突变

基因突变

FAIM2基因的碱基突变：           仅显示部分snp
rs188459       rs188460       rs297909       rs297910       rs297911       rs297912       rs297915       rs297916       rs297917       rs297918       rs297919       rs297920       rs297921       rs297922       rs297923       rs297924       rs297925      

基因表达

基因表达

FAIM2基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
ACTGGAGGGTCAATGAAGG
59
AGGATGGTGTAGACCTTTCTG
59
GTACTGGGCATCCTATGCT
59
GGAGAATCAGGTTCCAGGG
59
CCTGGAACCTGATTCTCCTG
60
GAGGTGAAGTCGAACTGGA
59
TCTTCGTGCTTCTCATGAC
58
CAAGTGCCAGGAAATATTGG
57
GTGTATTTACATTGTTCCTGGC
58
ATATACTCCTCAGGGCTCAG
58
GTGTATTTACATTGTTCCTGGC
58
ATATACTCCTCAGGGCTCAG
58
CACCATCCTGCTGATTCAG
58
GAACACAGCATAGGATGCC
58
TCAGAAAGGTCTACACCATCC
59
ACATAGTCCTTGACAGGGTC
59
GGAACCTGATTCTCCTGACC
60
AGGTGGTGTTGTAGTAGCTG
60
GTATTTACATTGTTCCTGGCAC
58
AATATACTCCTCAGGGCTCAG
59

转录因子

转录因子

      尚未收录相关数据

基因本体信息

FAIM2基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

FAIM2基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0016021
A0A0A0MTP9 (UniProtKB)
IEA
GO:0016021
F8VV65 (UniProtKB)
IEA
GO:0016021
F8VZI9 (UniProtKB)
IEA
GO:0016021
F8W1L3 (UniProtKB)
IEA
GO:0016021
H0YIR3 (UniProtKB)
IEA
GO:0002931
Q9BWQ8 (UniProtKB)
IEA
GO:0006915
Q9BWQ8 (UniProtKB)
IEA
GO:0016021
Q9BWQ8 (UniProtKB)
IEA
GO:0021549
Q9BWQ8 (UniProtKB)
ISS
GO:0021680
Q9BWQ8 (UniProtKB)
ISS
GO:0021681
Q9BWQ8 (UniProtKB)
ISS
GO:0021702
Q9BWQ8 (UniProtKB)
ISS
GO:0030054
Q9BWQ8 (UniProtKB)
IEA
GO:0043066
Q9BWQ8 (UniProtKB)
NAS
GO:0043523
Q9BWQ8 (UniProtKB)
IMP
GO:0043524
Q9BWQ8 (UniProtKB)
IEA
GO:0045121
Q9BWQ8 (UniProtKB)
IDA
GO:0045211
Q9BWQ8 (UniProtKB)
IEA
GO:2001234
Q9BWQ8 (UniProtKB)
IEA

基因相关microRNA

基因相关microRNA

可能调控 FAIM2基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

String
BioGrid
mentha
MINT
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关联基因 作用方式 资源库来源/分值

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Obesity 0.014006695 12 12 BeFree_GAD
Diabetes Mellitus, Non-Insulin-Dependent 0.002367032 1 0 GAD
Myocardial Infarction 0.000271442 1 0 BeFree
Hypertensive disease 0.000271442 1 4 BeFree
Neuroblastoma 0.000271442 1 0 BeFree
Secondary malignant neoplasm of lung 0.000271442 1 0 BeFree
Central neuroblastoma 0.000271442 1 0 BeFree
Neoplasm Metastasis 0.000271442 1 0 BeFree
Dyslipidemias 0.000271442 1 0 BeFree

基因相关文献

基因相关文献

Influence of lifestyle on the FAIM2 promoter methylation between obese and lean children: a cohort study.
Wu Lijun, Zhao Xiaoyuan, Shen Yue, Huang Guimin, Zhang Meixian, Yan Yinkun, Hou Dongqing, Meng Linghui, Liu Junting, Cheng Hong, Mi Jie BMJ Open IF: 2.5 2016-01-05
Promoter methylation of fas apoptotic inhibitory molecule 2 gene is associated with obesity and dyslipidaemia in Chinese children.
Wu Lijun, Zhao Xiaoyuan, Shen Yue, Zhang Mei-Xian, Yan Yinkun, Hou Dongqing, Meng Linghui, Liu Junting, Cheng Hong, Mi Jie Diab Vasc Dis Res IF: 3.1 2016-01-07
Gene Expression Profiles of Main Olfactory Epithelium in Adenylyl Cyclase 3 Knockout Mice.
Wang Zhenshan, Zhou Yanfen, Luo Yingtao, Zhang Jing, Zhai Yunpeng, Yang Dong, Zhang Zhe, Li Yongchao, Storm Daniel R, Ma Runlin Z Int J Mol Sci IF: 3.226 2016-09-09
Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index.
Felix Janine F, Bradfield Jonathan P, Monnereau Claire, van der Valk Ralf J P, Stergiakouli Evie, Chesi Alessandra, Gaillard Romy, Feenstra Bjarke, Thiering Elisabeth, Kreiner-Møller Eskil, Mahajan Anubha, Pitkänen Niina, Joro Raimo, Cavadino Alana, Huikari Ville, Franks Steve, Groen-Blokhuis Maria M, Cousminer Diana L, Marsh Julie A, Lehtimäki Terho, Curtin John A, Vioque Jesus, Ahluwalia Tarunveer S, Myhre Ronny, Price Thomas S, Vilor-Tejedor Natalia, Yengo Loïc, Grarup Niels, Ntalla Ioanna, Ang Wei, Atalay Mustafa, Bisgaard Hans, Blakemore Alexandra I, Bonnefond Amelie, Carstensen Lisbeth, , , Eriksson Johan, Flexeder Claudia, Franke Lude, Geller Frank, Geserick Mandy, Hartikainen Anna-Liisa, Haworth Claire M A, Hirschhorn Joel N, Hofman Albert, Holm Jens-Christian, Horikoshi Momoko, Hottenga Jouke Jan, Huang Jinyan, Kadarmideen Haja N, Kähönen Mika, Kiess Wieland, Lakka Hanna-Maaria, Lakka Timo A, Lewin Alexandra M, Liang Liming, Lyytikäinen Leo-Pekka, Ma Baoshan, Magnus Per, McCormack Shana E, McMahon George, Mentch Frank D, Middeldorp Christel M, Murray Clare S, Pahkala Katja, Pers Tune H, Pfäffle Roland, Postma Dirkje S, Power Christine, Simpson Angela, Sengpiel Verena, Tiesler Carla M T, Torrent Maties, Uitterlinden André G, van Meurs Joyce B, Vinding Rebecca, Waage Johannes, Wardle Jane, Zeggini Eleftheria, Zemel Babette S, Dedoussis George V, Pedersen Oluf, Froguel Philippe, Sunyer Jordi, Plomin Robert, Jacobsson Bo, Hansen Torben, Gonzalez Juan R, Custovic Adnan, Raitakari Olli T, Pennell Craig E, Widén Elisabeth, Boomsma Dorret I, Koppelman Gerard H, Sebert Sylvain, Järvelin Marjo-Riitta, Hyppönen Elina, McCarthy Mark I, Lindi Virpi, Harri Niinikoski, Körner Antje, Bønnelykke Klaus, Heinrich Joachim, Melbye Mads, Rivadeneira Fernando, Hakonarson Hakon, Ring Susan M, Smith George Davey, Sørensen Thorkild I A, Timpson Nicholas J, Grant Struan F A, Jaddoe Vincent W V, , Hum Mol Genet IF: 3.1 2016-10-17
[Risk of obesity-related gene polymorphism on the incidence and durative of childhood obesity].
Zhao Xiao-yuan, Zhang Mei-xian, Cheng Hong, Yan Yin-kun, Wu Li-jun, Shen Yue, Mi Jie Zhonghua Liu Xing Bing Xue Za Zhi 2015-04-21
Associations of genetic variants in/near body mass index-associated genes with type 2 diabetes: a systematic meta-analysis.
Xi Bo, Takeuchi Fumihiko, Meirhaeghe Aline, Kato Norihiro, Chambers John C, Morris Andrew P, Cho Yoon Shin, Zhang Weihua, Mohlke Karen L, Kooner Jaspal S, Shu Xiao Ou, Pan Hongwei, Tai E Shyong, Pan Haiyan, Wu Jer-Yuarn, Zhou Donghao, Chandak Giriraj R, , , Clin Endocrinol (Oxf) IF: 2.8 2015-08-03
KRT13, FAIM2 and CYP2W1 mRNA expression in oral squamous cell carcinoma patients with risk habits.
Hartanto Firstine Kelsi, Karen-Ng Lee Peng, Vincent-Chong Vui King, Ismail Siti Mazlipah, Mustafa Wan Mahadzir Wan, Abraham Mannil Thomas, Tay Keng Kiong, Zain Rosnah Binti Asian Pac J Cancer Prev IF: 0.000 2015-12-08
[Impact of obesity-related gene polymorphism on risk of obesity and metabolic disorder in childhood].
Zhang Meixian, Zhao Xiaoyuan, Xi Bo, Shen Yue, Wu Lijun, Cheng Hong, Hou Dongqing, Mi Jie Zhonghua Yu Fang Yi Xue Za Zhi 2015-09-08
Characterizing gene-gene interactions in a statistical epistasis network of twelve candidate genes for obesity.
De Rishika, Hu Ting, Moore Jason H, Gilbert-Diamond Diane BioData Min IF: 7.9 2015-12-30
MYCN repression of Lifeguard/FAIM2 enhances neuroblastoma aggressiveness.
Planells-Ferrer L, Urresti J, Soriano A, Reix S, Murphy D M, Ferreres J C, Borràs F, Gallego S, Stallings R L, Moubarak R S, Segura M F, Comella J X Cell Death Dis IF: 12.2 2015-09-08

基因相关服务

基因相关服务

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