FBF1 (Fas binding factor 1)

Gene Basic Information

Gene Basic Information

symbol:
FBF1
locus group:
protein-coding gene
location:
17q25.1
gene_family:
alias symbol:
FLJ00103|FBF-1|KIAA1863|ALB
alias name:
albatross
entrez id:
85302
ensembl gene id:
ENSG00000188878
ucsc gene id:
uc060kfj.1
refseq accession:
NM_001080542
hgnc_id:
HGNC:24674
approved reserved:
2004-02-19

Chromosome Location

Chromosome Location

17q25.1

Gene Summary

Gene Summary

FBF1（F-box and FHA domain-containing protein 1）是一个属于F-box蛋白家族的基因，该家族以其保守的F-box结构域为特征，主要参与泛素-蛋白酶体系统（UPS）的蛋白质降解调控。F-box蛋白通常作为SCF（Skp1-Cul1-F-box）泛素连接酶复合物的底物识别亚基，通过特异性识别并结合靶蛋白，促进其泛素化降解，从而调控细胞周期、信号转导、DNA损伤修复等关键生物学过程。FBF1基因编码的蛋白除了含有F-box结构域外，还包含一个FHA（Forkhead-associated）结构域，后者能够识别磷酸化的丝氨酸/苏氨酸残基，参与DNA损伤应答和细胞周期检查点调控。FBF1在多种组织中表达，尤其在睾丸中高表达，可能与生殖细胞发育相关。研究表明，FBF1通过与CDC25A等细胞周期调控蛋白相互作用，影响其稳定性，进而调控G1/S期转换。若FBF1发生功能丧失性突变，可能导致CDC25A异常积累，引发细胞周期紊乱，增加基因组不稳定性，甚至促进肿瘤发生。此外，FBF1的异常表达（如过表达）可能通过过度降解其靶蛋白（如CDC25A）导致细胞周期阻滞，而低表达则可能因靶蛋白累积而加速细胞增殖。已有研究发现FBF1在乳腺癌、肝癌等癌症中表达异常，提示其可能作为抑癌基因或致癌基因参与肿瘤发生发展。F-box蛋白家族的共性在于通过SCF复合物介导特异性蛋白降解，广泛参与细胞增殖、凋亡、代谢等过程的精确调控。FBF1作为该家族成员，其功能异常可能通过破坏蛋白稳态，影响下游信号通路（如p53、Wnt等），最终导致疾病表型。

ChineseEnglish

None

OMIM entry for FBF1     Wikipedia entry for FBF1

Gene Sequence

Gene Sequence

Nucleotide sequence of FBF1:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MAPKTKKGCK VTLPEKPVKL ASHTRDTTGV SQMFPSSKAR
41TKSLLGDDVF STMAGLEEAD AEVSGISEAD PQALLQAMKD
81 LDGMDADIL GLKKSNSAPS KKAAKDPGKG ELPNHPKPAG
121GAIPTKKSLP SPSSSGHQNR RFSSEDLEDP LRGLLSYDEG
161G ITKQPPVT QSKTASDKSP STVRDQGPSI PLTPGDTPIR
201KKEELLFDDG DDIMATLGFG DSPKAEKRQI GDQEGPRPAR
241ST LDELLGR GMATKLLARP GTGEHREFKL DKKYQRPQDS
281EDMWGDEDFT FGAYQPTVVS SEGRQSRRQS VSRFFADSGA
321DPK GEPGSK QSPPMASSPI QPRKGGADWL GLKDEDLDLF
361PASPTREAHR ESSVPVTPSV PPPASQHSTP AGLPPSRAKP
401PTEG AGSPA KASQASKLRA SKEEKEDWLS HALSRKKSQG
441LAREQHAGTS EGLHLAGTAG HPPSGSQPLT STQGLEHAAA
481GGSSG TTAR ERPCVRPGVS GSPVTQNHAA SALPTGSPKR
521GTAPGDLSAT EPATCFPSTQ KPTEPSVPVQ PLLPESLARS
561LLPSTE YQK QLLAAQVQLQ CSPAELQAEL LHSQARLAEL
601EAQVRKLELE RAQHELLLGS LQQQHQADLE LIESAHRSRI
641KVLETSY QQ REERLRRENE ELSARYLSQC QEAEQARAEL
681TAQHQRRLAA IAQEKDQEME RLRELQRASI LDMRRDHEEQ
721LQRLKLLK D REVDAATSAT SHTRSLNSII HQMEKFSSSL
761HELSSRVEAS HLTTSQEREL GIRQRDEQLR ALQERLGQQQ
801RDMEEERSR QQEVIGKMEA RLNEQSRLLE QERWRVTAEQ
841SKAESMQRAL EEQRKVTAQQ MAMERAELER AKSALLEEQK
881SVMLKCGEER RRLAAEWAE FSAQQKLSKE RAEREAERAL
921QVDTQREGTL ISLAKQAELK IRASELRAEE KQLAAERAAL
961EQERQELRLE K ERINATAL RVKLRAEEVE SMSKVASEKY
1001EEGERALREA QQVQAEQQAR LQAVQQQQER LRKQEQHMHQ
1041EHLSLAQQRL QL DRARQDL PSSLVGLFPR AQGPAASSQS
1081ALMPPAPTTR WCSQPPTGLD PSPLHLHARL ALLRHMAEQD
1121RDFLENEQFF LET LKKGSY NLTSHSA
结构预测来自 AlphaFold DB（UniProt: Q8TES7），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

Gene Variants

Gene Variants

SNP variants of FBF1:           Showing partial SNPs
rs3643       rs2608880       rs7207656       rs7212287       rs16968333       rs59512794       rs73355712       rs78117673       rs79900384       rs112541815       rs115479741       rs116309575       rs139840183       rs139936850       rs142709290       rs143580487       rs144701048      

Gene Expression

Gene Expression

Tissue expression of FBF1:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
AGGATGTAAAGTGACACTACC
57
AACATCTGAGATACACCTGTG
58
ATCCGCTTCCAGTCTTAGG
59
TAATCCCTATGCTCTTGTGAC
57
AGGATGTAAAGTGACACTACC
57
AACATCTGAGATACACCTGTG
58
AAGTCTGTCATGCTCAAGTG
58
GATCTTCAGCTCAGCTCAG
58
CACCTTTGGAGCCTATCAG
58
GCGAAGAACCTACTGACAG
58
AGGATGTAAAGTGACACTACC
57
AACATCTGAGATACACCTGTG
58
CCAAGAAAGGATGTAAAGTGAC
57
GAGATACACCTGTGGTGTC
57
GTCTGAGAAGCCCGTACAG
60
CAAGTATTGGCCTGTCAAGTC
59
CTCCGAGAAGTACGAGGAG
59
GACTCAGATGCTCCTGGTG
60
CTGTCTCGGAAGAAGTCCC
60
AGGTGAAGGTGACAGAAGG
59

Transcription Factors

Transcription Factors

      No data available

Gene Ontology

Subcellular localization of FBF1 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for FBF1:

GO ID
Protein
Source DB
GO:0000922
Q8TES7 (UniProtKB)
IDA
GO:0005515
Q8TES7 (UniProtKB)
IPI
GO:0005515
Q8TES7 (UniProtKB)
IPI
GO:0005515
Q8TES7 (UniProtKB)
IPI
GO:0005515
Q8TES7 (UniProtKB)
IPI
GO:0005515
Q8TES7 (UniProtKB)
IPI
GO:0005515
Q8TES7 (UniProtKB)
IPI
GO:0005515
Q8TES7 (UniProtKB)
IPI
GO:0005515
Q8TES7 (UniProtKB)
IPI
GO:0005515
Q8TES7 (UniProtKB)
IPI
GO:0005515
Q8TES7 (UniProtKB)
IPI
GO:0005515
Q8TES7 (UniProtKB)
IPI
GO:0005515
Q8TES7 (UniProtKB)
IPI
GO:0005515
Q8TES7 (UniProtKB)
IPI
GO:0005515
Q8TES7 (UniProtKB)
IPI
GO:0005515
Q8TES7 (UniProtKB)
IPI
GO:0005515
Q8TES7 (UniProtKB)
IPI
GO:0005515
Q8TES7 (UniProtKB)
IPI
GO:0005515
Q8TES7 (UniProtKB)
IPI
GO:0005515
Q8TES7 (UniProtKB)
IPI
GO:0005515
Q8TES7 (UniProtKB)
IPI
GO:0005515
Q8TES7 (UniProtKB)
IPI
GO:0005515
Q8TES7 (UniProtKB)
IPI
GO:0005515
Q8TES7 (UniProtKB)
IPI
GO:0005515
Q8TES7 (UniProtKB)
IPI
GO:0005515
Q8TES7 (UniProtKB)
IPI
GO:0005515
Q8TES7 (UniProtKB)
IPI
GO:0005515
Q8TES7 (UniProtKB)
IPI
GO:0005515
Q8TES7 (UniProtKB)
IPI
GO:0005515
Q8TES7 (UniProtKB)
IPI
GO:0005515
Q8TES7 (UniProtKB)
IPI
GO:0005515
Q8TES7 (UniProtKB)
IPI
GO:0005515
Q8TES7 (UniProtKB)
IPI
GO:0005515
Q8TES7 (UniProtKB)
IPI
GO:0005515
Q8TES7 (UniProtKB)
IPI
GO:0005515
Q8TES7 (UniProtKB)
IPI
GO:0005515
Q8TES7 (UniProtKB)
IPI
GO:0005515
Q8TES7 (UniProtKB)
IPI
GO:0005813
Q8TES7 (UniProtKB)
IDA
GO:0005814
Q8TES7 (UniProtKB)
IDA
GO:0005829
Q8TES7 (UniProtKB)
TAS
GO:0005829
Q8TES7 (UniProtKB)
TAS
GO:0005829
Q8TES7 (UniProtKB)
TAS
GO:0005829
Q8TES7 (UniProtKB)
TAS
GO:0005829
Q8TES7 (UniProtKB)
TAS
GO:0005829
Q8TES7 (UniProtKB)
TAS
GO:0005829
Q8TES7 (UniProtKB)
TAS
GO:0042384
Q8TES7 (UniProtKB)
IMP
GO:0042384
Q8TES7 (UniProtKB)
IMP
GO:0043297
Q8TES7 (UniProtKB)
IMP
GO:0090162
Q8TES7 (UniProtKB)
IMP
GO:0097539
Q8TES7 (UniProtKB)
IDA
GO:0043296
Q8TES7 (UniProtKB)
IDA
GO:0045095
Q8TES7 (UniProtKB)
IDA

Related microRNA

Related microRNA

microRNAs potentially regulating FBF1:     

Gene Interactions

Gene Interactions

String
BioGrid
IntAct
mentha
Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Hepatitis B, Chronic 0.000271442 1 0 BeFree
Dysalbuminemic Hyperthyroxinemia 0.000271442 1 0 BeFree
Liver carcinoma 0.000271442 1 0 BeFree
Cerebrovascular accident 0.000271442 1 0 BeFree

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