FCMR (Fc mu receptor)
- symbol:
- FCMR
- locus group:
- protein-coding gene
- location:
- 1q32.1
- gene_family:
- Immunoglobulin-like domain containing
- alias symbol:
- TOSO|FcmuR
- alias name:
- IgM Fc receptor|Fc mu R
- entrez id:
- 9214
- ensembl gene id:
- ENSG00000162894
- ucsc gene id:
- None
- refseq accession:
- NM_005449
- hgnc_id:
- HGNC:14315
- approved reserved:
- 2005-04-04
FCMR（也称为FcμR或TOSO）是编码Fcμ受体的基因，属于免疫球蛋白超家族（Immunoglobulin superfamily），主要表达于B细胞和T细胞表面。其编码的FcμR蛋白是一种特异性结合IgM抗体的受体，参与B细胞活化、免疫调节和抗体反馈抑制。FcμR通过结合IgM的恒定区（Fc region）调控B细胞受体（BCR）信号通路，影响体液免疫应答。该基因突变可能导致免疫失调，如自身免疫疾病（如系统性红斑狼疮）或免疫缺陷。FCMR过表达可能增强B细胞活化和抗体产生，但可能引发过度免疫反应；而降低表达可能导致对病原体的清除能力下降或免疫耐受异常。FCMR属于Fc受体基因家族（Fc receptor family），该家族成员均能结合免疫球蛋白（如IgG、IgA、IgM等）的Fc片段，参与免疫复合物清除、细胞吞噬和炎症调节。研究表明，FCMR在慢性淋巴细胞白血病（CLL）中常过表达，可能促进肿瘤细胞存活。其功能还涉及凋亡抑制，因FCMR能激活抗凋亡信号通路（如NF-κB）。专业术语解释：IgM（免疫球蛋白M，最早产生的抗体类型）、BCR（B细胞受体，负责识别抗原）、NF-κB（核因子κB，调控炎症和细胞存活的转录因子）。目前中文术语"FcμR"或"TOSO"均用于指代该基因/蛋白，尚无统一译名。
Fc receptors specifically bind to the Fc region of immunoglobulins (Igs) to mediate the unique functions of each Ig class. FAIM3 encodes an Fc receptor for IgM (see MIM 147020) (Kubagawa et al., 2009 [PubMed 19858324]; Shima et al., 2010 [PubMed 20042454]).[supplied by OMIM, Jul 2010]
Gene Ontology
Subcellular localization of FCMR (and its protein):
- plasma membrane
- cytoplasm
- extracellular
- golgi
- vesicle
- cytoskeleton
- endoplasmic reticulum
- nucleus
- endosome
- lysosome
- mitochondrion
Gene Ontology (GO) terms for FCMR:
| Interacting Gene | Interaction | Source/Score |
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