FLT1基因详情-基因数据库-基因云馆

FLT1 (fms related receptor tyrosine kinase 1)

symbol:: FLT1
locus group:: protein-coding gene
location:: 13q12.3
gene_family:: Receptor Tyrosine Kinases|I-set domain containing|Immunoglobulin-like domain containing
alias symbol:: VEGFR1
alias name:: vascular endothelial growth fact...
entrez id:: 2321
ensembl gene id:: ENSG00000102755
ucsc gene id:: uc001usb.4
refseq accession:: NM_002019
hgnc_id:: HGNC:3763
approved reserved:: 1986-01-01

13q12.3

FLT1（Fms相关酪氨酸激酶1）是一种编码血管内皮生长因子受体1（VEGFR-1）的基因，属于VEGFR家族。该家族还包括FLK1（VEGFR-2）和FLT4（VEGFR-3），它们共同参与调控血管生成和淋巴管生成。FLT1主要通过与血管内皮生长因子（VEGF-A、VEGF-B）和胎盘生长因子（PlGF）结合来发挥作用，但其激酶活性较弱，主要作为诱饵受体调节VEGF信号通路的可用性，从而影响血管形成和维持血管稳态。FLT1在胚胎发育、伤口愈合和女性生殖系统（如胎盘形成）中起关键作用。FLT1的突变或表达异常与多种疾病相关，例如子痫前期患者中可溶性FLT1（sFLT1）水平升高会抑制VEGF信号，导致血管功能障碍和高血压。此外，FLT1在肿瘤血管生成中也有重要作用，其过表达可能促进肿瘤生长和转移，而降低表达则可能抑制血管生成，但同时也可能影响正常血管功能。FLT1基因家族成员均含有免疫球蛋白样结构域和酪氨酸激酶结构域，通过调控细胞增殖、迁移和存活来影响血管及淋巴管系统的发育和功能。

中文English

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OMIM数据库中对FLT1基因的介绍 Wikipedia数据库中对FLT1基因的介绍

FLT1基因的碱基序列：[NCBI]

Loading Gene Browser...

蛋白质序列

1MVSYWDTGVL LCALLSCLLL TGSSSGSKLK DPELSLKGTQ
41HIMQAGQTLH LQCRGEAAHK WSLPEMVSKE SERLSITKSA
81
CGRNGKQFC STLTLNTAQA NHTGFYSCKY LAVPTSKKKE
121TESAIYIFIS DTGRPFVEMY SEIPEIIHMT EGRELVIPCR
161V
TSPNITVT LKKFPLDTLI PDGKRIIWDS RKGFIISNAT
201YKEIGLLTCE ATVNGHLYKT NYLTHRQTNT IIDVQISTPR
241PV
KLLRGHT LVLNCTATTP LNTRVQMTWS YPDEKNKRAS
281VRRRIDQSNS HANIFYSVLT IDKMQNKDKG LYTCRVRSGP
321SFK
SVNTSV HIYDKAFITV KHRKQQVLET VAGKRSYRLS
361MKVKAFPSPE VVWLKDGLPA TEKSARYLTR GYSLIIKDVT
401EEDA
GNYTI LLSIKQSNVF KNLTATLIVN VKPQIYEKAV
441SSFPDPALYP LGSRQILTCT AYGIPQPTIK WFWHPCNHNH
481SEARC
DFCS NNEESFILDA DSNMGNRIES ITQRMAIIEG
521KNKMASTLVV ADSRISGIYI CIASNKVGTV GRNISFYITD
561VPNGFH
VNL EKMPTEGEDL KLSCTVNKFL YRDVTWILLR
601TVNNRTMHYS ISKQKMAITK EHSITLNLTI MNVSLQDSGT
641YACRARN
VY TGEEILQKKE ITIRDQEAPY LLRNLSDHTV
681AISSSTTLDC HANGVPEPQI TWFKNNHKIQ QEPGIILGPG
721SSTLFIER
V TEEDEGVYHC KATNQKGSVE SSAYLTVQGT
761SDKSNLELIT LTCTCVAATL FWLLLTLFIR KMKRSSSEIK
801TDYLSIIMD
 PDEVPLDEQC ERLPYDASKW EFARERLKLG
841KSLGRGAFGK VVQASAFGIK KSPTCRTVAV KMLKEGATAS
881EYKALMTELK 
ILTHIGHHL NVVNLLGACT KQGGPLMVIV
921EYCKYGNLSN YLKSKRDLFF LNKDAALHME PKKEKMEPGL
961EQGKKPRLDS V
TSSESFAS SGFQEDKSLS DVEEEEDSDG
1001FYKEPITMED LISYSFQVAR GMEFLSSRKC IHRDLAARNI
1041LLSENNVVKI CD
FGLARDI YKNPDYVRKG DTRLPLKWMA
1081PESIFDKIYS TKSDVWSYGV LLWEIFSLGG SPYPGVQMDE
1121DFCSRLREGM RMR
APEYST PEIYQIMLDC WHRDPKERPR
1161FAELVEKLGD LLQANVQQDG KDYIPINAIL TGNSGFTYST
1201PAFSEDFFKE SISA
PKFNS GSSDDVRYVN AFKFMSLERI
1241KTFEELLPNA TSMFDDYQGD SSTLLASPML KRFTWTDSKP
1281KASLKIDLRV TSKSK
ESGL SDVSRPSFCH SSCGHVSEGK
1321RRFTYDHAEL ERKIACCSPP PDYNSVVLYS TPPI

结构预测来自 AlphaFold DB（UniProt: P17948），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

FLT1基因的碱基突变：仅显示部分snp

rs966 rs583105 rs585421 rs588907 rs589809 rs598945 rs600263 rs600640 rs602608 rs605929 rs610612 rs612536 rs612564 rs612627 rs614820 rs615529 rs616342

FLT1基因在不同组织中的表达： [UniProt]

正向引物序列

正向Tm值

反向引物序列

反向Tm值

评分

CTCAAGATTGACTTGAGAGTAACC

59

CTGGAATGGCAGAAACTGG

59

GGAAAGAATAAGCTTCCACCA

58

GAAGGAAATGGAAGTAGTTGGA

58

TCTACTTGTTGATTCTGACGG

58

GAAGACAGGAACTCCATGC

58

TTTCTCAACAAGGATGCAGC

59

TTGGTTTCTTGCCTTGTTCC

59

AGAATAAGATGGCTAGCACC

57

CCAACTTTATTGGAAGCTATGC

58

CTCAAGATTGACTTGAGAGTAACC

59

CTGGAATGGCAGAAACTGG

59

CTCAAGATTGACTTGAGAGTAACC

59

CTGGAATGGCAGAAACTGG

59

CATTCCGAAGCAAGGTGTG

60

TTCTGTTTCCCATGTTGCTG

59

GATGAAGGTGTCTATCACTGC

59

TCCGAGGTTCCTTGAACAG

59

TGTCATGCTAATGGTGTCC

58

TGATGTATACAGTTCAGGCTC

57

转录因子

影响基因

影响类型

参考文献链接（PubMed）

ATF1

FLT1

Unknown

7499271

CREB1

FLT1

Unknown

7499271

E2F1

FLT1

Unknown

20516113

EGR1

FLT1

Unknown

10828020

EPAS1

FLT1

Activation

15192019; 19616846

ESR1

FLT1

Unknown

17242190

ETS1

FLT1

Unknown

10554042

TP53

FLT1

Activation

16432214

TP53

FLT1

Unknown

1724219e

FLT1基因（以及对应的蛋白质）的细胞分布位置：

[UniProt] [GenomeNet]

质膜
细胞质
细胞外
高尔基体
囊泡
细胞骨架
内质网
细胞核
内体
溶酶体
线粒体

FLT1基因的本体（GO）信息：

GO库代码

对应的蛋白质

来源代码

GO:0004713

H9N1E7 (UniProtKB)

IEA

GO:0005524

H9N1E7 (UniProtKB)

IEA

GO:0018108

H9N1E7 (UniProtKB)

IEA

GO:0000186

P17948 (UniProtKB)

IEA

GO:0001525

P17948 (UniProtKB)

IEA

GO:0001666

P17948 (UniProtKB)

IEA

GO:0002548

P17948 (UniProtKB)

IDA

GO:0002548

P17948 (UniProtKB)

IDA

GO:0004714

P17948 (UniProtKB)

TAS

GO:0005021

P17948 (UniProtKB)

IMP

GO:0005021

P17948 (UniProtKB)

IDA

GO:0005021

P17948 (UniProtKB)

IDA

GO:0005515

P17948 (UniProtKB)

IPI

GO:0005515

P17948 (UniProtKB)

IPI

GO:0005515

P17948 (UniProtKB)

IPI

GO:0005515

P17948 (UniProtKB)

IPI

GO:0005515

P17948 (UniProtKB)

IPI

GO:0005515

P17948 (UniProtKB)

IPI

GO:0005515

P17948 (UniProtKB)

IPI

GO:0005515

P17948 (UniProtKB)

IPI

GO:0005515

P17948 (UniProtKB)

IPI

GO:0005515

P17948 (UniProtKB)

IPI

GO:0005515

P17948 (UniProtKB)

IPI

GO:0005515

P17948 (UniProtKB)

IPI

GO:0005515

P17948 (UniProtKB)

IPI

GO:0005515

P17948 (UniProtKB)

IPI

GO:0005515

P17948 (UniProtKB)

IPI

GO:0005515

P17948 (UniProtKB)

IPI

GO:0005515

P17948 (UniProtKB)

IPI

GO:0005515

P17948 (UniProtKB)

IPI

GO:0005515

P17948 (UniProtKB)

IPI

GO:0005524

P17948 (UniProtKB)

IEA

GO:0005615

P17948 (UniProtKB)

TAS

GO:0005768

P17948 (UniProtKB)

IEA

GO:0005886

P17948 (UniProtKB)

TAS

GO:0005886

P17948 (UniProtKB)

TAS

GO:0005887

P17948 (UniProtKB)

IDA

GO:0005925

P17948 (UniProtKB)

IDA

GO:0006940

P17948 (UniProtKB)

IEA

GO:0007169

P17948 (UniProtKB)

TAS

GO:0008284

P17948 (UniProtKB)

TAS

GO:0010863

P17948 (UniProtKB)

IMP

GO:0014068

P17948 (UniProtKB)

IMP

GO:0016477

P17948 (UniProtKB)

IMP

GO:0018108

P17948 (UniProtKB)

IDA

GO:0018108

P17948 (UniProtKB)

IDA

GO:0019838

P17948 (UniProtKB)

IPI

GO:0019838

P17948 (UniProtKB)

IPI

GO:0019838

P17948 (UniProtKB)

IPI

GO:0019838

P17948 (UniProtKB)

IPI

GO:0019838

P17948 (UniProtKB)

IPI

GO:0019838

P17948 (UniProtKB)

IPI

GO:0030154

P17948 (UniProtKB)

IEA

GO:0030335

P17948 (UniProtKB)

IDA

GO:0030522

P17948 (UniProtKB)

IEA

GO:0030949

P17948 (UniProtKB)

IDA

GO:0035924

P17948 (UniProtKB)

IDA

GO:0036323

P17948 (UniProtKB)

IDA

GO:0036326

P17948 (UniProtKB)

IDA

GO:0036327

P17948 (UniProtKB)

IDA

GO:0036332

P17948 (UniProtKB)

IDA

GO:0038084

P17948 (UniProtKB)

IEA

GO:0043235

P17948 (UniProtKB)

IDA

GO:0043406

P17948 (UniProtKB)

IDA

GO:0043410

P17948 (UniProtKB)

IDA

GO:0043552

P17948 (UniProtKB)

IMP

GO:0045766

P17948 (UniProtKB)

IMP

GO:0046777

P17948 (UniProtKB)

IDA

GO:0046777

P17948 (UniProtKB)

IDA

GO:0048010

P17948 (UniProtKB)

IMP

GO:0048010

P17948 (UniProtKB)

IDA

GO:0048010

P17948 (UniProtKB)

TAS

GO:0048010

P17948 (UniProtKB)

TAS

GO:0048514

P17948 (UniProtKB)

ISS

GO:0048598

P17948 (UniProtKB)

ISS

GO:0048661

P17948 (UniProtKB)

IEA

可能调控 FLT1基因的相关microRNA：

hsa-miR-155 hsa-mir-221/222cluster hsa-miR-100 hsa-miR-200b hsa-miR-200c

String

BioGrid

IntAct

mentha

MINT

Reactome

加载中…

关联基因	作用方式	资源库来源/分值

KEGG
Reactomepathway

名称
4014 Ras signaling pathway [PATH:hsa04014]
4015 Rap1 signaling pathway [PATH:hsa04015]
4066 HIF-1 signaling pathway [PATH:hsa04066]
4151 PI3K-Akt signaling pathway [PATH:hsa04151]
4060 Cytokine-cytokine receptor interaction [PATH:hsa04060]
4144 Endocytosis [PATH:hsa04144]
4510 Focal adhesion [PATH:hsa04510]
5202 Transcriptional misregulation in cancers [PATH:hsa05202]
5323 Rheumatoid arthritis [PATH:hsa05323]

名称
Neurophilin interactions with VEGF and VEGFR
Signal Transduction
Signaling by VEGF
VEGF binds to VEGFR leading to receptor dimerization
VEGF ligand-receptor interactions

疾病名称

关系值

NofPmids

NofSnps

来源

疾病名称	关系值	NofPmids	NofSnps	来源
Mammary Neoplasms	0.20408156	8	0	BeFree_CTD_human_LHGDN_RGD
Liver Cirrhosis	0.200271442	2	0	BeFree_CTD_human_RGD
Cerebral Hemorrhage	0.2	1	0	CTD_human_RGD
Pre-Eclampsia	0.168323668	19	0	CTD_human_GAD_LHGDN
melanoma	0.130530151	12	0	BeFree_CTD_human_GAD_LHGDN
Neoplasm Metastasis	0.12842463	23	0	BeFree_CTD_human_LHGDN
Renal Cell Carcinoma	0.12408156	7	0	BeFree_CTD_human_LHGDN
Skin Neoplasms	0.122367032	1	0	CTD_human_GAD
Drug-Induced Liver Injury	0.12	1	0	CTD_human
Disease Progression	0.12	1	0	CTD_human

Proteomic Analysis of Endothelial Activation Induced by Adult Angiostrongylus vasorum Homogenate: Insights into Vascular Remodeling and Hemostatic Imbalance.

Collado-Cuadrado M, Rodríguez-Escolar I, Balmori-de la Puente A, Montero-Calle A, Vázquez-Ávila S, Macchioni F, Barderas R, Sotillo J, Pericacho M, Morchón R Animals (Basel) IF: 3.2 2026-03-15

Preeclampsia Genomic Susceptibility Factors in Populations of African Ancestry: A Systematic Review and Meta-Analysis.

Katsukunya JN, Davidson B, Mnika K, Soko ND, Osman A, Matjila M, Jones E, Dandara C Int J Mol Sci IF: 3.226 2026-03-12

Identifying active compounds and revealing integrated mechanism of phytomedicines via AI-driven chemical-biological information fusion: a case study of Weifuchun.

Luo Z, Xu Y, Wang Y, Cheng N J Ethnopharmacol IF: 6.8 2026-07-15

Novel Insights into the Pathogenic Role of CSF1R in Endometriosis.

Ye L, Sun J, Lu C, Chen C, Chen Q, Zhu H, Ding P, Wu X, Huang Y, Zhang L Reprod Sci IF: 2.8 2026-06-00

CMV titer associations with cognition and the plasma proteome implicate FLT1 and neurovascular mechanisms as potential moderators.

Duggan MR, Jacobsen E, Yang S, Zeng X, Kandala S, Joynes CM, Karikari TK, Nimgaonkar VL, Kamboh MI, Snitz BE, Ferrucci L, Yolken R, Ganguli M, Walker KA J Neuroinflammation IF: 5.102 2026-04-16

Multi-Omics and Machine Learning-Uncovered FLT1-Mediated Epithelial-Endothelial Crosstalk in Cellular Senescence Driving Clear Cell Renal Cell Carcinoma Malignancy.

Sun M, Mao H, Luo Y, Yang M, He Z, Li S, Liu Z, Peng L, Zhang Q, Zhang J, Zhang Y FASEB J IF: 4.3 2026-04-30

Efficient Downregulation of Flt-1 Mediated by Splice Switching ASO in Murine Endothelial Cells.

Blitek M, Le Coz O, Ogor V, Fakih HH, Khvorova A, Goyenvalle A Nucleic Acid Ther IF: 4.5 2026-06-00

LINC00607 facilitates endothelial VEGF-A receptor FLT1 splicing.

Lam F, Warwick T, Oo JA, Krüger AY, Kreis NN, Diagel A, Izquierdo Ponce J, Tirunagari P, Bayer ME, Nonn O, Dechend R, Walther T, Boon RA, Baker AH, Günther S, Wittig I, Chen Z, Müller-McNicoll M, Louwen F, Brandes RP, Leisegang MS Mol Ther IF: 11.4 2026-07-01

Composite proteomic and metabolomic plasma biomarkers for detection of colorectal, lung and ovarian cancers.

Ögren JÅ, Ekström J, Rameika N, Torell E, Larsson C, Stoimenov I, Micke P, Gyllensten U, Hellström M, Glimelius B, Stålberg K, Sjöblom T Mol Cancer IF: 6.204 2026-04-07

Epigenetic dichotomy in florid vs. gliotic proliferative diabetic retinopathy: hypomethylation of EGLN1 and MMP9 drives divergent pathogenic pathways in angiogenesis and fibrosis.

Ren X, Cui L, Yao Y, Qiu Y, Yu C, Guo J Front Endocrinol (Lausanne) IF: 5.7 None

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FLT1 (fms related receptor tyrosine kinase 1)

基因基本信息

基因基本信息

基因染色体位置

基因染色体位置

基因简述

基因简述

基因序列

基因序列

编码蛋白质

编码蛋白质

基因突变

基因突变

基因表达

基因表达

基因引物

基因引物

转录因子

转录因子

基因本体信息

基因相关microRNA

基因相关microRNA

基因相互作用关系

基因相互作用关系

基因通路

基因通路

基因相关疾病

基因相关疾病

基因相关文献

基因相关文献

基因相关服务

基因相关服务

基因相关评论

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