FYN (FYN proto-oncogene, Src family tyrosine kinase)

Gene Basic Information

Gene Basic Information

symbol
FYN
locus group
protein-coding gene
location
6q21
gene_family
SH2 domain containing
alias symbol
SYN|SLK|MGC45350
alias name
None
entrez id
2534
ensembl gene id
ENSG00000010810
ucsc gene id
uc003pvk.3
refseq accession
NM_001370529
hgnc_id
HGNC:4037
approved reserved
1988-08-19

Chromosome Location

Chromosome Location

6q21

Gene Summary

Gene Summary

ChineseEnglish

This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist. [provided by RefSeq, Jul 2008]

OMIM entry for FYN     Wikipedia entry for FYN

Gene Sequence

Gene Sequence

Nucleotide sequence of FYN:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MGCVQCKDKE ATKLTEERDG SLNQSSGYRY GTDPTPQHYP
41SFGVTSIPNY NNFHAAGGQG LTVFGGVNSS SHTGTLRTRG
81 GTGVTLFVA LYDYEARTED DLSFHKGEKF QILNSSEGDW
121WEARSLTTGE TGYIPSNYVA PVDSIQAEEW YFGKLGRKDA
161E RQLLSFGN PRGTFLIRES ETTKGAYSLS IRDWDDMKGD
201HVKHYKIRKL DNGGYYITTR AQFETLQQLV QHYSERAAGL
241CC RLVVPCH KGMPRLTDLS VKTKDVWEIP RESLQLIKRL
281GNGQFGEVWM GTWNGNTKVA IKTLKPGTMS PESFLEEAQI
321MKK LKHDKL VQLYAVVSEE PIYIVTEYMN KGSLLDFLKD
361GEGRALKLPN LVDMAAQVAA GMAYIERMNY IHRDLRSANI
401LVGN GLICK IADFGLARLI EDNEYTARQG AKFPIKWTAP
441EAALYGRFTI KSDVWSFGIL LTELVTKGRV PYPGMNNREV
481LEQVE RGYR MPCPQDCPIS LHELMIHCWK KDPEERPTFE
521YLQSFLEDYF TATEPQYQPG ENL
Structure predicted by AlphaFold DB(UniProt: P06241). Color indicates pLDDT confidence (dark blue = high, yellow/orange = low).

Gene Variants

Gene Variants

SNP variants of FYN:           Showing partial SNPs
rs12910       rs697640       rs697641       rs697642       rs706861       rs706862       rs706863       rs706864       rs706865       rs706866       rs706867       rs706868       rs706869       rs706870       rs706871       rs706872       rs706873      

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
CTCTTCATCACAGGGAAGGA
59
AGCCACATAATTGCTGGGA
59
AAGGACTCACCGTCTTTGG
60
AAGAGTGTCACTCCTGTTCC
59
TGGATACTACATTACCACCCG
59
AAACCATCAGCTTTCTCTGAG
58
TATTGAACAGCTCGGAAGG
57
CATAATTGCTGGGAATGTAACC
57
TGGATACTACATTACCACCCG
59
AAACCATCAGCTTTCTCTGAG
58
AAGGACTCACCGTCTTTGG
60
AAGAGTGTCACTCCTGTTCC
59
TATTGAACAGCTCGGAAGG
57
CATAATTGCTGGGAATGTAACC
58
CGACAGCTATTGTCCTTTGG
59
AAAGTGAATAGGCACCTTTGG
59
TATCCAGGCAGAAGAGTGG
59
TCTTGGGTTTCCAAAGGAC
58
AAGGACTCACCGTCTTTGG
59
AAGAGTGTCACTCCTGTTCC
59

Gene Ontology

Subcellular localization of FYN (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for FYN:

GO ID
Protein
Source DB
GO:0000165
P06241 (UniProtKB)
TAS
GO:0001664
P06241 (UniProtKB)
IEA
GO:0001764
P06241 (UniProtKB)
IEA
GO:0001948
P06241 (UniProtKB)
IPI
GO:0002223
P06241 (UniProtKB)
TAS
GO:0002250
P06241 (UniProtKB)
IEA
GO:0004713
P06241 (UniProtKB)
EXP
GO:0004713
P06241 (UniProtKB)
EXP
GO:0004713
P06241 (UniProtKB)
EXP
GO:0004713
P06241 (UniProtKB)
EXP
GO:0004713
P06241 (UniProtKB)
EXP
GO:0004713
P06241 (UniProtKB)
EXP
GO:0004713
P06241 (UniProtKB)
IMP
GO:0004713
P06241 (UniProtKB)
EXP
GO:0004713
P06241 (UniProtKB)
EXP
GO:0004713
P06241 (UniProtKB)
EXP
GO:0004713
P06241 (UniProtKB)
TAS
GO:0004713
P06241 (UniProtKB)
TAS
GO:0004713
P06241 (UniProtKB)
TAS
GO:0004713
P06241 (UniProtKB)
TAS
GO:0004713
P06241 (UniProtKB)
TAS
GO:0004713
P06241 (UniProtKB)
TAS
GO:0004713
P06241 (UniProtKB)
TAS
GO:0004713
P06241 (UniProtKB)
TAS
GO:0004713
P06241 (UniProtKB)
TAS
GO:0004715
P06241 (UniProtKB)
IBA
GO:0004715
P06241 (UniProtKB)
NAS
GO:0005088
P06241 (UniProtKB)
TAS
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005524
P06241 (UniProtKB)
IEA
GO:0005634
P06241 (UniProtKB)
IEA
GO:0005739
P06241 (UniProtKB)
IEA
GO:0005768
P06241 (UniProtKB)
IDA
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005884
P06241 (UniProtKB)
IEA
GO:0005886
P06241 (UniProtKB)
IDA
GO:0005886
P06241 (UniProtKB)
IDA
GO:0006468
P06241 (UniProtKB)
NAS
GO:0006816
P06241 (UniProtKB)
NAS
GO:0007169
P06241 (UniProtKB)
IBA
GO:0007411
P06241 (UniProtKB)
TAS
GO:0007417
P06241 (UniProtKB)
IBA
GO:0007596
P06241 (UniProtKB)
TAS
GO:0007612
P06241 (UniProtKB)
TAS
GO:0007631
P06241 (UniProtKB)
TAS
GO:0008360
P06241 (UniProtKB)
IEA
GO:0010629
P06241 (UniProtKB)
IEA
GO:0010976
P06241 (UniProtKB)
IEA
GO:0014066
P06241 (UniProtKB)
TAS
GO:0014068
P06241 (UniProtKB)
IEA
GO:0014069
P06241 (UniProtKB)
IEA
GO:0015631
P06241 (UniProtKB)
IEA
GO:0016032
P06241 (UniProtKB)
IEA
GO:0016477
P06241 (UniProtKB)
IBA
GO:0018108
P06241 (UniProtKB)
IMP
GO:0030154
P06241 (UniProtKB)
IBA
GO:0030168
P06241 (UniProtKB)
TAS
GO:0030900
P06241 (UniProtKB)
IEA
GO:0031234
P06241 (UniProtKB)
IBA
GO:0031295
P06241 (UniProtKB)
TAS
GO:0031295
P06241 (UniProtKB)
TAS
GO:0031397
P06241 (UniProtKB)
IEA
GO:0035556
P06241 (UniProtKB)
TAS
GO:0036120
P06241 (UniProtKB)
IEA
GO:0038083
P06241 (UniProtKB)
IBA
GO:0038096
P06241 (UniProtKB)
TAS
GO:0042110
P06241 (UniProtKB)
IBA
GO:0042127
P06241 (UniProtKB)
IBA
GO:0042177
P06241 (UniProtKB)
IEA
GO:0042493
P06241 (UniProtKB)
IEA
GO:0042523
P06241 (UniProtKB)
IEA
GO:0042608
P06241 (UniProtKB)
IEA
GO:0042609
P06241 (UniProtKB)
IEA
GO:0042610
P06241 (UniProtKB)
IEA
GO:0042981
P06241 (UniProtKB)
IBA
GO:0043123
P06241 (UniProtKB)
IEA
GO:0043524
P06241 (UniProtKB)
IEA
GO:0043547
P06241 (UniProtKB)
IEA
GO:0043548
P06241 (UniProtKB)
IEA
GO:0044325
P06241 (UniProtKB)
IEA
GO:0045087
P06241 (UniProtKB)
IBA
GO:0045471
P06241 (UniProtKB)
IEA
GO:0046854
P06241 (UniProtKB)
IEA
GO:0046872
P06241 (UniProtKB)
IEA
GO:0046875
P06241 (UniProtKB)
IPI
GO:0046934
P06241 (UniProtKB)
TAS
GO:0048010
P06241 (UniProtKB)
TAS
GO:0048013
P06241 (UniProtKB)
TAS
GO:0048015
P06241 (UniProtKB)
TAS
GO:0048813
P06241 (UniProtKB)
IEA
GO:0050690
P06241 (UniProtKB)
TAS
GO:0050798
P06241 (UniProtKB)
IEA
GO:0050852
P06241 (UniProtKB)
IDA
GO:0050900
P06241 (UniProtKB)
TAS
GO:0050966
P06241 (UniProtKB)
IEA
GO:0051428
P06241 (UniProtKB)
IEA
GO:0070851
P06241 (UniProtKB)
IPI
GO:0071375
P06241 (UniProtKB)
IEA
GO:0071560
P06241 (UniProtKB)
IEA
GO:1900182
P06241 (UniProtKB)
IEA
GO:2001240
P06241 (UniProtKB)
IEA
GO:0045121
P06241 (UniProtKB)
IDA

Related microRNA

Related microRNA

microRNAs potentially regulating FYN:     

Gene Interactions

Gene Interactions

String
BioGrid
IntAct
mentha
MINT
Reactome
Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Peripheral T-Cell Lymphoma 0.120271442 1 0 BeFree_CTD_human
Stomach Neoplasms 0.12 1 0 CTD_human
Catalepsy 0.12 1 0 CTD_human
Adult T-Cell Lymphoma/Leukemia 0.12 1 0 CTD_human
Sepsis 0.08 1 0 RGD
Epilepsy, Temporal Lobe 0.08 1 0 RGD
Alzheimer's Disease 0.010454206 5 0 BeFree_GAD_LHGDN
Asthma 0.005634266 2 5 BeFree_GAD_LHGDN
Schizophrenia 0.00554839 5 0 BeFree_GAD
Bipolar Disorder 0.005276948 2 0 BeFree_GAD

Related Publications

Related Publications

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Multi-tissue multi-omics integration reveals tissue-specific pathways, gene networks and drug candidates for type 1 diabetes.
Blencowe M, Saleem Z, Liu R, Wang M, Tseng IH, Wier J, Mutter S, Vaida F, Guo Y, Sandholm N, Ackeifi C, Kaufman DL, Yang X Diabetologia IF: 10.4 2026-07-00
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