G6PD (glucose-6-phosphate dehydrogenase)

Gene Basic Information

Gene Basic Information

symbol
G6PD
locus group
protein-coding gene
location
Xq28
gene_family
-
alias symbol
G6PD1
alias name
None
entrez id
2539
ensembl gene id
ENSG00000160211
ucsc gene id
uc004flx.3
refseq accession
NM_000402
hgnc_id
HGNC:4057
approved reserved
2001-06-22

Chromosome Location

Chromosome Location

Xq28

Gene Summary

Gene Summary

ChineseEnglish

This gene encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

OMIM entry for G6PD     Wikipedia entry for G6PD

Gene Sequence

Gene Sequence

Nucleotide sequence of G6PD:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MAEQVALSRT QVCGILREEL FQGDAFHQSD THIFIIMGAS
41GDLAKKKIYP TIWWLFRDGL LPENTFIVGY ARSRLTVADI
81 RKQSEPFFK ATPEEKLKLE DFFARNSYVA GQYDDAASYQ
121RLNSHMNALH LGSQANRLFY LALPPTVYEA VTKNIHESCM
161S QIGWNRII VEKPFGRDLQ SSDRLSNHIS SLFREDQIYR
201IDHYLGKEMV QNLMVLRFAN RIFGPIWNRD NIACVILTFK
241EP FGTEGRG GYFDEFGIIR DVMQNHLLQM LCLVAMEKPA
281STNSDDVRDE KVKVLKCISE VQANNVVLGQ YVGNPDGEGE
321ATK GYLDDP TVPRGSTTAT FAAVVLYVEN ERWDGVPFIL
361RCGKALNERK AEVRLQFHDV AGDIFHQQCK RNELVIRVQP
401NEAV YTKMM TKKPGMFFNP EESELDLTYG NRYKNVKLPD
441AYERLILDVF CGSQMHFVRS DELREAWRIF TPLLHQIELE
481KPKPI PYIY GSRGPTEADE LMKRVGFQYE GTYKWVNPHK
521L
Structure predicted by AlphaFold DB(UniProt: P11413). Color indicates pLDDT confidence (dark blue = high, yellow/orange = low).

Gene Variants

Gene Variants

SNP variants of G6PD:           Showing partial SNPs
rs782820967       rs782820705       rs782818844       rs782820643       rs782817663       rs782818094       rs782807000       rs782806405       rs782805743       rs782806127       rs782804684       rs782801832       rs782797399       rs782799512       rs782796928       rs782795806       rs782794403      

Gene Expression

Gene Expression

Tissue expression of G6PD:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
AGTGAGCCCTTCTTCAAGG
59
CAAGGCCAGGTAGAAGAGG
60
CCCTATATTTATGGCAGCCGA
60
GTAGGTGCCCTCATACTGG
59
TGCATGAGCCAGATCAGAG
60
GAACAGGGAGGAGATGTGG
60
CATCCGCAAACAGAGTGAG
59
AAGAAGTCCTCCAGCTTGAG
60
CCCTATATTTATGGCAGCCGA
60
GTAGGTGCCCTCATACTGG
59
GATGATGACCAAGAAGCCG
59
GAGCTTCACGTTCTTGTATCTG
60
CTTCCATCAGTCGGATACAC
58
CTCTGTTTGCGGATGTCAG
59
CCCTATATTTATGGCAGCCGA
60
GTAGGTGCCCTCATACTGG
59
TGCATGAGCCAGATCAGAG
60
GAACAGGGAGGAGATGTGG
60
ATTTGGGATCATCCGGGAC
60
ACGTCATCTGAGTTGGTGG
60

Transcription Factors

Transcription Factors

Transcription Factors
Target Gene
Interaction Type
PubMed References
CREM
G6PD
Repression
17273168

Gene Ontology

Subcellular localization of G6PD (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for G6PD:

GO ID
Protein
Source DB
GO:0004345
E7EM57 (UniProtKB)
IEA
GO:0005737
E7EM57 (UniProtKB)
IDA
GO:0005815
E7EM57 (UniProtKB)
IDA
GO:0006006
E7EM57 (UniProtKB)
IEA
GO:0006098
E7EM57 (UniProtKB)
IEA
GO:0050661
E7EM57 (UniProtKB)
IEA
GO:0055114
E7EM57 (UniProtKB)
IEA
GO:0004345
E7EUI8 (UniProtKB)
IEA
GO:0005737
E7EUI8 (UniProtKB)
IDA
GO:0005815
E7EUI8 (UniProtKB)
IDA
GO:0006006
E7EUI8 (UniProtKB)
IEA
GO:0006098
E7EUI8 (UniProtKB)
IEA
GO:0050661
E7EUI8 (UniProtKB)
IEA
GO:0055114
E7EUI8 (UniProtKB)
IEA
GO:0004345
E9PD92 (UniProtKB)
IEA
GO:0005737
E9PD92 (UniProtKB)
IDA
GO:0005815
E9PD92 (UniProtKB)
IDA
GO:0006006
E9PD92 (UniProtKB)
IEA
GO:0050661
E9PD92 (UniProtKB)
IEA
GO:0055114
E9PD92 (UniProtKB)
IEA
GO:0004345
P11413 (UniProtKB)
EXP
GO:0004345
P11413 (UniProtKB)
IDA
GO:0004345
P11413 (UniProtKB)
IMP
GO:0004345
P11413 (UniProtKB)
IMP
GO:0004345
P11413 (UniProtKB)
IMP
GO:0005515
P11413 (UniProtKB)
IPI
GO:0005515
P11413 (UniProtKB)
IPI
GO:0005536
P11413 (UniProtKB)
IDA
GO:0005536
P11413 (UniProtKB)
IMP
GO:0005634
P11413 (UniProtKB)
IEA
GO:0005737
P11413 (UniProtKB)
IDA
GO:0005737
P11413 (UniProtKB)
IDA
GO:0005813
P11413 (UniProtKB)
IDA
GO:0005815
P11413 (UniProtKB)
IDA
GO:0005829
P11413 (UniProtKB)
IDA
GO:0005829
P11413 (UniProtKB)
TAS
GO:0006006
P11413 (UniProtKB)
IEA
GO:0006098
P11413 (UniProtKB)
IDA
GO:0006098
P11413 (UniProtKB)
TAS
GO:0006629
P11413 (UniProtKB)
TAS
GO:0006695
P11413 (UniProtKB)
IMP
GO:0006739
P11413 (UniProtKB)
IDA
GO:0006740
P11413 (UniProtKB)
IMP
GO:0006749
P11413 (UniProtKB)
IMP
GO:0006749
P11413 (UniProtKB)
IMP
GO:0009051
P11413 (UniProtKB)
IMP
GO:0009898
P11413 (UniProtKB)
IDA
GO:0010734
P11413 (UniProtKB)
IMP
GO:0014070
P11413 (UniProtKB)
IEA
GO:0016020
P11413 (UniProtKB)
IDA
GO:0019322
P11413 (UniProtKB)
IDA
GO:0021762
P11413 (UniProtKB)
IEP
GO:0032094
P11413 (UniProtKB)
IEA
GO:0034599
P11413 (UniProtKB)
IMP
GO:0042802
P11413 (UniProtKB)
IPI
GO:0042802
P11413 (UniProtKB)
IPI
GO:0042803
P11413 (UniProtKB)
IPI
GO:0043231
P11413 (UniProtKB)
IDA
GO:0043249
P11413 (UniProtKB)
IMP
GO:0043523
P11413 (UniProtKB)
IEA
GO:0045471
P11413 (UniProtKB)
IEA
GO:0046390
P11413 (UniProtKB)
IMP
GO:0050661
P11413 (UniProtKB)
IDA
GO:0051156
P11413 (UniProtKB)
IDA
GO:0051156
P11413 (UniProtKB)
IMP
GO:0055114
P11413 (UniProtKB)
IMP
GO:0070062
P11413 (UniProtKB)
IDA
GO:0070062
P11413 (UniProtKB)
IDA

Related microRNA

Related microRNA

microRNAs potentially regulating G6PD:     

Gene Interactions

Gene Interactions

String
BioGrid
IntAct
mentha
MINT
Reactome
Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Deficiency of glucose-6-phosphate dehydrogenase 0.243440631 191 3 BeFree_CTD_human_GAD_LHGDN
ANEMIA, NONSPHEROCYTIC HEMOLYTIC, DUE TO G6PD DEFICIENCY 0.24 16 27 CLINVAR_UNIPROT
Anemia, Hemolytic 0.144926502 57 2 BeFree_CTD_human_GAD_LHGDN
Favism 0.130705785 24 1 BeFree_CTD_human_GAD
Hemolysis (disorder) 0.129468128 6 0 CTD_human_GAD
Anemia, Hemolytic, Congenital Nonspherocytic 0.122714419 12 0 BeFree_CTD_human
Chronic granulomatous disease 0.120271442 2 0 BeFree_CTD_human
Contact Dermatitis 0.12 1 0 CTD_human
Acute kidney injury 0.12 3 0 CTD_human
Phagocyte Bactericidal Dysfunction 0.12 1 0 CTD_human

Related Publications

Related Publications

Targeting G6PD (Glucose-6-Phosphate Dehydrogenase) as a Biomarker of Therapeutic Vulnerability in Renal Cell Carcinoma.
Ferreira DP, Mizael ACS, Cabrieira JVB, Silva RVN, Araújo LS, Silva CA, Ribeiro KB, Michelleti AMR, Machado JR, Lira RCP Int J Mol Sci IF: 3.226 2026-03-20
Disturbances in Central Sensitization Are Associated with Disease Severity and Alterations in Gene Expression Measured in the Peripheral Blood Mononuclear Cells of Patients with Rheumatoid Arthritis.
Tchetina E, Potapova A, Vienozinskaite A, Glukhova S, Cherkasova M, Filatova E, Karateev A, Lila A Int J Mol Sci IF: 3.226 2026-03-22
Neuraxial-Enhanced Hemodynamic Control in a Nine-Year-Old Child With Pheochromocytoma: A Case Report.
Muawad R, Alzughaibi NM, AlManea K, Al Farhan A, Alnamshan M, AlDhuwaihy A, Alessa ME, Alomar F Cureus 2026-02-00
G6PD variants but not Filipino beta-thalassemia are associated with reduced risk of Plasmodium knowlesi infection in Sabah, Malaysia.
Nuin NA, Rajahram GS, Barber BE, Anstey NM, Grigg MJ, Chua TH Malar J IF: 2.715 2026-04-15
Lower efficacy of transfusion of red blood cells from donors with sickle cell trait.
Dzieciatkowska M, Stephenson D, Hay A, Wang X, Keele GR, Nemkov T, Deng X, Stone M, Hansen KC, Kleinman S, Norris PJ, Busch MP, Page GP, Spitalnik SL, Roubinian N, Zimring JC, Thein SL, D'Alessandro A Hemasphere 2026-04-00
Characterisation of malaria and glucose-6-phosphate dehydrogenase deficiency in conflict-affected zones of southern and eastern Sudan.
Jebreel WMA, Abdel Hamid MM, Mustafa SA, Awad F, Chamai M, Malpartida-Cardenas K, Boadu EA, Amoah LE, Rodriguez-Manzano J, Cunnington AJ, Mohamed AO, NIHR Global Health Research Group on Digital Diagnostics for African Health Systems BMC Infect Dis IF: 2.768 2026-04-17
14-3-3σ alleviates UVB-induced epidermal oxidative stress through the pentose phosphate pathway promotion.
Deng X, Fu Z, Niu X, Lian P, Liu H, Wang Y, Li F, Zhou M J Photochem Photobiol B IF: 4.0 2026-06-00

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