GOT1 (glutamic-oxaloacetic transaminase 1)

Gene Basic Information

Gene Basic Information

symbol
GOT1
locus group
protein-coding gene
location
10q24.2
gene_family
-
alias symbol
AST1|SGOT|AST
alias name
aspartate aminotransferase 1|aspar…
entrez id
2805
ensembl gene id
ENSG00000120053
ucsc gene id
uc001kpr.4
refseq accession
NM_002079
hgnc_id
HGNC:4432
approved reserved
2001-06-22

Chromosome Location

Chromosome Location

10q24.2

Gene Summary

Gene Summary

ChineseEnglish

Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. [provided by RefSeq, Jul 2008]

OMIM entry for GOT1     Wikipedia entry for GOT1

Gene Sequence

Gene Sequence

Nucleotide sequence of GOT1:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MAPPSVFAEV PQAQPVLVFK LTADFREDPD PRKVNLGVGA
41YRTDDCHPWV LPVVKKVEQK IANDNSLNHE YLPILGLAEF
81 RSCASRLAL GDDSPALKEK RVGGVQSLGG TGALRIGADF
121LARWYNGTNN KNTPVYVSSP TWENHNAVFS AAGFKDIRSY
161R YWDAEKRG LDLQGFLNDL ENAPEFSIVV LHACAHNPTG
201IDPTPEQWKQ IASVMKHRFL FPFFDSAYQG FASGNLERDA
241WA IRYFVSE GFEFFCAQSF SKNFGLYNER VGNLTVVGKE
281PESILQVLSQ MEKIVRITWS NPPAQGARIV ASTLSNPELF
321EEW TGNVKT MADRILTMRS ELRARLEALK TPGTWNHITD
361QIGMFSFTGL NPKQVEYLVN EKHIYLLPSG RINVSGLTTK
401NLDY VATSI HEAVTKIQ
Structure predicted by AlphaFold DB(UniProt: P17174). Color indicates pLDDT confidence (dark blue = high, yellow/orange = low).

Gene Variants

Gene Variants

SNP variants of GOT1:           Showing partial SNPs
rs2641       rs2642       rs11867       rs1126878       rs1802508       rs1802509       rs1892505       rs2234971       rs2275952       rs2490280       rs2490281       rs2494651       rs2862611       rs2862612       rs2862613       rs2862614       rs2902275      

Gene Expression

Gene Expression

Tissue expression of GOT1:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
TGTCCTGGTCTTCAAGCTC
59
GATATGCTCCCACTCCCAG
59
GCTCTTTGAGGAATGGACAG
58
CTTCTAGTCGTGCCCTGAG
59
TCCTGGTCTTCAAGCTCAC
59
GATATGCTCCCACTCCCAG
59
CTCTTTGAGGAATGGACAGGT
59
CTTCTAGTCGTGCCCTGAG
59
TCTTTGAGGAATGGACAGGT
58
CTTCTAGTCGTGCCCTGAG
59
CTGGTCTTCAAGCTCACTG
58
GATATGCTCCCACTCCCAG
59

Gene Ontology

Subcellular localization of GOT1 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for GOT1:

GO ID
Protein
Source DB
GO:0004069
P17174 (UniProtKB)
ISS
GO:0004069
P17174 (UniProtKB)
IDA
GO:0004069
P17174 (UniProtKB)
IDA
GO:0004069
P17174 (UniProtKB)
IDA
GO:0004069
P17174 (UniProtKB)
IDA
GO:0004069
P17174 (UniProtKB)
TAS
GO:0004069
P17174 (UniProtKB)
TAS
GO:0004609
P17174 (UniProtKB)
IEA
GO:0005634
P17174 (UniProtKB)
IDA
GO:0005737
P17174 (UniProtKB)
IDA
GO:0005764
P17174 (UniProtKB)
IEA
GO:0005829
P17174 (UniProtKB)
IBA
GO:0005829
P17174 (UniProtKB)
TAS
GO:0005829
P17174 (UniProtKB)
TAS
GO:0006094
P17174 (UniProtKB)
TAS
GO:0006103
P17174 (UniProtKB)
ISS
GO:0006107
P17174 (UniProtKB)
IEA
GO:0006114
P17174 (UniProtKB)
ISS
GO:0006531
P17174 (UniProtKB)
ISS
GO:0006532
P17174 (UniProtKB)
IBA
GO:0006533
P17174 (UniProtKB)
IDA
GO:0006536
P17174 (UniProtKB)
ISS
GO:0007219
P17174 (UniProtKB)
IEA
GO:0008652
P17174 (UniProtKB)
TAS
GO:0019550
P17174 (UniProtKB)
IEA
GO:0019551
P17174 (UniProtKB)
IEA
GO:0030170
P17174 (UniProtKB)
IBA
GO:0031406
P17174 (UniProtKB)
IEA
GO:0032869
P17174 (UniProtKB)
IEP
GO:0042802
P17174 (UniProtKB)
IBA
GO:0043679
P17174 (UniProtKB)
IEA
GO:0047801
P17174 (UniProtKB)
ISS
GO:0051384
P17174 (UniProtKB)
IEP
GO:0055089
P17174 (UniProtKB)
IEA
GO:0070062
P17174 (UniProtKB)
IDA
GO:0070062
P17174 (UniProtKB)
IDA
GO:0070062
P17174 (UniProtKB)
IDA
GO:0070062
P17174 (UniProtKB)
IDA
GO:0070062
P17174 (UniProtKB)
IDA
GO:0080130
P17174 (UniProtKB)
IEA
GO:0005739
P17174 (UniProtKB)
IBA

Related microRNA

Related microRNA

microRNAs potentially regulating GOT1:     

Gene Interactions

Gene Interactions

String
BioGrid
IntAct
mentha
Reactome
Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Liver Cirrhosis, Experimental 0.12 1 0 CTD_human
ASPARTATE AMINOTRANSFERASE, SERUM LEVEL OF, QUANTITATIVE TRAIT LOCUS 1 0.12 0 0 CLINVAR
Crohn Disease 0.007372538 4 2 BeFree_GAD
Ulcerative Colitis 0.007101096 3 1 GAD
Periodontal Diseases 0.00272435 1 0 LHGDN
Biliary cirrhosis 0.00272435 1 0 LHGDN
Severe Acute Respiratory Syndrome 0.00272435 1 0 LHGDN
Impaired glucose tolerance 0.00272435 1 0 LHGDN
Alcoholic Intoxication, Chronic 0.002367032 1 0 GAD
Preleukemia 0.000542884 2 0 BeFree

Related Publications

Related Publications

GOT1 inhibits hepatocellular carcinoma progression by regulating SLC25A5-dependent mitochondrial apoptosis.
Zong W, Cheng C, Zhang Y, Lu Y, Lian Z, Luo T, Li Y, Yu D Oncogene IF: 9.1 2026-06-00
Redox imbalance dictates dependence on GOT1 versus GOT2 for rod photoreceptor health during aging and stress.
Chen M, Weh E, Goswami MT, Weh KM, Hager H, Sajjakulnukit P, Weingarten A, Subramanya S, Miller N, Chaudhury S, Piraino E, Chandel NS, Ryals RC, Lyssiotis CA, Wubben TJ bioRxiv 2026-04-07
Defining pain trajectories in juvenile arthritis and associated patient characteristics.
Mensink MO, de Roock S, Drylewicz J, Jenniskens K, Wulffraat N, Swart JF, Eijkelkamp N Arthritis Res Ther IF: 0.000 2026-04-18
Glioma biomarker analysis and drug targeting prediction based on ferroptosis-related genes.
Zhang Y, Wu D, Gu Y, Xiao H Medicine (Baltimore) IF: 2.0 2026-04-10
Oncolytic virus hijacks GOT1 and pyrimidinosomes to fuel pyrimidine synthesis for replication in tumor cells.
Tang N, Gong Y, Zhao C, Niu Y, Tan L, Song C, Qiu X, Liao Y, Yu S, Ding C, Lin S, Sun Y Tumour Virus Res IF: 3.8 2026-06-00
MEN1/menin deficiency suppresses hepatocellular carcinogenesis via disrupting mitophagy-mediated mitochondrial homeostasis.
Chen C, Yu D, Tang D, Liu M, Zhu J, Wang X, Dan G, Chen L, Tang S, Tian Q, Wang H, Meng F, Zhang T, Guo B, Chen T, Li H, Jin B Autophagy IF: 18.6 2026-06-10
Transsulfuration links aspartate-asparagine metabolism and redox homeo-stasis to drive tumor growth.
Milosevic M, Dmytruk K, Alghadi A, Jakoube P, Wong Soon J, Hyrossova P, Bin Munim M, Fernandes SI, Shevzov-Zebrun A, Stanko R, Mitric I, Cockova Z, Kucera L, Fernández-García J, Benda A, Marzullo B, Sedlacek R, Neuzil J, Fendt SM, Tennant DA, Vander Heiden MG, Rohlenova K, Rohlena J bioRxiv 2026-07-13

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