GSR (glutathione-disulfide reductase)

Gene Basic Information

Gene Basic Information

symbol
GSR
locus group
protein-coding gene
location
8p12
gene_family
-
alias symbol
-
alias name
glutathione S-reductase
entrez id
2936
ensembl gene id
ENSG00000104687
ucsc gene id
uc003xih.3
refseq accession
NM_000637
hgnc_id
HGNC:4623
approved reserved
2001-06-22

Chromosome Location

Chromosome Location

8p12

Gene Summary

Gene Summary

ChineseEnglish

This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2010]

OMIM entry for GSR     Wikipedia entry for GSR

Gene Sequence

Gene Sequence

Nucleotide sequence of GSR:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MALLPRALSA GAGPSWRRAA RAFRGFLLLL PEPAALTRAL
41SRAMACRQEP QPQGPPPAAG AVASYDYLVI GGGSGGLASA
81 RRAAELGAR AAVVESHKLG GTCVNVGCVP KKVMWNTAVH
121SEFMHDHADY GFPSCEGKFN WRVIKEKRDA YVSRLNAIYQ
161N NLTKSHIE IIRGHAAFTS DPKPTIEVSG KKYTAPHILI
201ATGGMPSTPH ESQIPGASLG ITSDGFFQLE ELPGRSVIVG
241AG YIAVEMA GILSALGSKT SLMIRHDKVL RSFDSMISTN
281CTEELENAGV EVLKFSQVKE VKKTLSGLEV SMVTAVPGRL
321PVM TMIPDV DCLLWAIGRV PNTKDLSLNK LGIQTDDKGH
361IIVDEFQNTN VKGIYAVGDV CGKALLTPVA IAAGRKLAHR
401LFEY KEDSK LDYNNIPTVV FSHPPIGTVG LTEDEAIHKY
441GIENVKTYST SFTPMYHAVT KRKTKCVMKM VCANKEEKVV
481GIHMQ GLGC DEMLQGFAVA VKMGATKADF DNTVAIHPTS
521SEELVTLR
Structure predicted by AlphaFold DB(UniProt: P00390). Color indicates pLDDT confidence (dark blue = high, yellow/orange = low).

Gene Variants

Gene Variants

SNP variants of GSR:           Showing partial SNPs
rs3594       rs14203       rs889926       rs961267       rs1002149       rs1125853       rs1138054       rs1138089       rs1138092       rs1138107       rs1138117       rs1318983       rs1465102       rs1465477       rs1465478       rs1465479       rs1554991      

Gene Expression

Gene Expression

Tissue expression of GSR:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
ATGACTACCTGGTGATCGG
59
ATCCAACATTCACGCAAGTG
60
TACATTGCTGTGGAGATGG
57
TTCTAAGTACCTTATCATGCCG
58
TCAATGATCAGCACCAACTG
59
TAACCTCCTTGACCTGGGA
60
TACATTGCTGTGGAGATGG
57
CCTCCTTGACCTTATCATGC
58
ACAATCTCACCAAGTCCCA
59
ACTGACCTCTATTGTGGGC
59
GATGATACGGCATGATAAGGG
59
GCAGCTATTGCAACTGGAG
59
GGGTAAATTCAATTGGCGTG
58
GATTTCTATATGGGACTTGGTGAG
59
CTGATGATACGGCATGATAAGG
59
CTATTGCAACTGGAGTAAGAAGAG
59
AGGGTAAATTCAATTGGCGT
58
TTTCTATATGGGACTTGGTGAG
57
TTACATTGCTGTGGAGATGG
58
TCTAAGTACCTTATCATGCCGT
59

Gene Ontology

Subcellular localization of GSR (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for GSR:

GO ID
Protein
Source DB
GO:0016491
E5RI06 (UniProtKB)
IEA
GO:0055114
E5RI06 (UniProtKB)
IEA
GO:0016668
H0YC68 (UniProtKB)
IEA
GO:0055114
H0YC68 (UniProtKB)
IEA
GO:0000302
P00390 (UniProtKB)
TAS
GO:0004362
P00390 (UniProtKB)
TAS
GO:0004362
P00390 (UniProtKB)
TAS
GO:0005759
P00390 (UniProtKB)
TAS
GO:0005829
P00390 (UniProtKB)
TAS
GO:0006749
P00390 (UniProtKB)
IEA
GO:0009055
P00390 (UniProtKB)
TAS
GO:0009897
P00390 (UniProtKB)
IEA
GO:0015949
P00390 (UniProtKB)
TAS
GO:0045454
P00390 (UniProtKB)
IEA
GO:0050660
P00390 (UniProtKB)
IEA
GO:0050661
P00390 (UniProtKB)
IEA
GO:0055114
P00390 (UniProtKB)
IEA
GO:0070062
P00390 (UniProtKB)
IDA
GO:0070062
P00390 (UniProtKB)
IDA
GO:0070062
P00390 (UniProtKB)
IDA
GO:0098869
P00390 (UniProtKB)
IEA

Related microRNA

Related microRNA

microRNAs potentially regulating GSR:     

Gene Interactions

Gene Interactions

String
BioGrid
IntAct
mentha
MINT
Reactome
Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Hyperthyroidism 0.2 2 0 CTD_human_RGD
Diabetes Mellitus, Experimental 0.2 3 0 CTD_human_RGD
Parkinsonian Disorders 0.2 2 0 CTD_human_RGD
Edema 0.12 1 0 CTD_human
Contact Dermatitis 0.12 1 0 CTD_human
Protein Deficiency 0.12 1 0 CTD_human
Amyotrophic Lateral Sclerosis 0.12 1 0 CTD_human
Neurodegenerative Disorders 0.12 1 0 CTD_human
Hypoglycemia 0.12 1 0 CTD_human
Anemia, Hemolytic 0.12 1 0 CTD_human

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Alshehri MA, Alghamdi A, Binshaya AS, Juraybi TN, Abalkhail A, Alissa M Tissue Cell 2026-10-00
Global Signal Removal (GSR) as graph spatial filtering.
Arab F, Sipes BS, Nagarajan SS, Raj A bioRxiv 2026-04-09
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Valenzuela-Villatoro M, de la Cruz-Ruiz P, Guerrero-Gómez D, Gómez-Orte E, Schiavi A, Maglioni S, Montero M, Fonteriz RI, Casas-Martínez JC, Briand NE, Xu J, Rodriguez-Palero MJ, Artal-Sanz M, Olek K, Polaczyk J, Turek M, Pokrzywa W, Xu S, Irazoqui JE, McDonagh B, Álvarez J, Olmedo M, Ventura N, Cabello J, Miranda-Vizuete A Redox Biol IF: 16.2 2026-06-00
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Alissa M, Alghamdi SA, Safhi AY, Binshaya AS, Juraybi TN, Alqarni AM, Albati AA, Abalkhail A Tissue Cell 2026-08-00
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